hybridization oligonucleotides for the IGF-I and AR are as follows: IGF-I: sense, 5'-AAATCAGCAGTCTTGGAACC-3'; antisense, 5' CTTCTGGGTCTTGGGCATGT 3'; oligonucleotide, 5'-CAAGCCCACAG-GGTATGGCTCCAGCAGT-3'; AR: sense, 5'-GATGCTCTACTTCGCCCCTGA-3'; antisense, 5'-CCCAGCAAATAGAATTCCATGAC-3'; oligonucleotide, 5'-CTGGGTGTGGAAATAGATG-3'; and GAP: sense, 5'-GGTATCGTGGAAGGACTCAT-3'; antisense, 5'-TCCACCACCCTGT-TGCTGTA-3'; oligonucleotide, 5'-GTGGGTGTCGCTGTTGAAGT-3'.
Clinical studies however have shown links between prolonged use of the drug and problems of liver toxicity similar to those found with other 17α-alkylated steroids. Even in small