Not necessarily, if your organs are in good order then I don't think it is required. Of course there are some supplements which are healthy regardless but stuff like TUDCA would only be beneficial if your liver is stressed.
I take it year round and just adjust the dosage depending on what I am doing as far as PED's. N2Guard is the product I use and have been for years. I break it down a few ways personally:
-10 caps per day if on a cycle with tren and orals
-7 caps per day if on any other cycle that includes orals
-5 caps per day if on an injectable only cycle without liver toxic compounds
-3 caps per day when not using anything.