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nizoral shampoo everyday?

I believe they say "you can attain the best cosmetic results from 3 times a week usage" but for AAS users, I find its just not enough. Taking AAS that puts your testosterone levels into supraphysiological levels, will, due to testosterone's conversion to DHT, put the levels of DHT up to supraphysiological levels. This will increase the amount of DHT binding to receptors on the scalp.

This long winded crap is just another way of saying that "AAS users should use nizoral shampoo every day." Though you should use it with a good conditioner, because nizoral can dry the living hell out of your hair.
 
eh2442 ,do you still loose hair with the proscar???why don't you bump up the dose or switch to dutatseride bro......or don't use the eq...i used it with finasteride and still noticed hairloss..so no more eq for me...maybe you can switch to var
 
cop said:
eh2442 ,do you still loose hair with the proscar???why don't you bump up the dose or switch to dutatseride bro......or don't use the eq...i used it with finasteride and still noticed hairloss..so no more eq for me...maybe you can switch to var
Click to expand...

As finateride only works on the 5AR enzyme's conversion of different steroids to DHT, it will not work with Eq because Eq does not convert to DHT. Eq converts to DHN, or dihydronandralone.
 
I use a combo of nioxin (all three steps, spray, shampoo conditioner), rogaine (only nightly), and propecia...

anyway nizoral would help if i sub'ed it for the nioxin a few times per week?
 
this stuff sounds like snake oil. think about it. shampoo is on your hair and scalp a matter of seconds before you rinse it down the drain.

dont see it can possibly keep your hair from falling out. can it magically absorb into your scalp for the few seconds you use it and stop hair loss? now propecia, which is taken internally or rogain, which is left on the scalp, could be effective.

shampoo is soap. wont stop your hair from falling out. wont turn your fine hair into a full head of hair. wont change unruly locks into a manageable head of hair. we are all suckered in by marketing.
 
Mastagon said:
As finateride only works on the 5AR enzyme's conversion of different steroids to DHT, it will not work with Eq because Eq does not convert to DHT. Eq converts to DHN, or dihydronandralone.
Click to expand...
:rolleyes: Um, I thought nandrolone, not boldenone, was reduced (via 5-ar mind you!) to dihydronandrolone - and THAT'S exactly why deca is a bad mix with finasteride!

I've not run accross the pharmacokinetics of boldenone pertinent to 5ar, but I believe you are correct in saying that eq is not subject to much action via 5ar.

Are you sure boldenone is converted to dhn, as is deca by 5ar? If so, and not by 5ar, then how?
 
there is some thoughts out there and some metabolic evidence that the boldenone gets 5 beta reduced, not alpha..my evidence is based off single administration of boldenone base or acetate(i forget which one,,will look it up later)..
 
I've found a couple sources saying it has a very low affinity for 5ar, but that a bit is reduced via 5ar to dihydroboldenone. Haven't come accross anything refering to 5 beta reduction - mainly because I'd not even have guessed to look. :)

lanky, you know off hand what it gets (5 beta) reduced to?

Quick, it's 1,4-androstadiene-3-one,17b-ol were talking about here! What does it reduce to? Think man, think!
 
the double bond on carbon 4 gets beta reduced, so you should be left with a 1-testosterone and its diol/dione metabolites(5 beta metabolites though)..dont quote me yet..i have to check some literature...i have tons of folders locked in the bedroom...it will take a few minutes to find.you guys are lucky i am off work this week..lol
 
i dont know what to tell you..all i can say is that boldenone does not 5 alpha reduce.....100% is 5beta reduced...i really dont know what implications that may hold. when it does reduce it forms a 5 beta version of 1-testosterone(we all know 1-testosterone is a potent steroid in its 5 alpha version)..I think most of the 1-testosterone products that were marketed before the ph ban were a mixture of 5 alpha and 5 beta. they were effective...PA said that 1-AD was a mixture of 5 alpha and 5 beta(synthesis of chemicals often produces isomers)....i really cant give you comparative anabolic ratings on a 5 alpha and 5 beta 1-tesatosterone product..you might have to ask patrick arnold when he gets out of jail in three months...though he will be on electronic monitoring for a while(feds will track him for life)....
 
unfortunatly my hairline is moonwalking backwards as well..the following is what i have found that made my hairline receed faster: accutane killed my hair,,recceeded 2 inches over three 6 month cycles,,,1-AD made my scalp feel tight and inflamation, lots of shedding even after 2 weeks, allthough the gains were incredible,,,,vitamin C @250-500mg/day seems to make my hair brittle and thin and scalp dry. when i am on a high soluble fiber diet my hair and scalp actually improves(i need to start to eat oatmeal again) . it would not be as bad if i looked good, but i look like rob schneider in deuce bigalow..
 
lol

Did any of the hair come back after accutane? I've read md's that said hair shedding with accutane is pretty identical to with retnin-a (which is sometimes prescribed to help "dead hair" fall out so new hair can grow.)

Curious, how did you use the 1-ad?

I've already started back into my oatmeal routine every morning.

Is there a 7 alpha methyl nandrolone thread yet? Should I start one? :)
 
Silent Method said:
lol

Did any of the hair come back after accutane? I've read md's that said hair shedding with accutane is pretty identical to with retnin-a (which is sometimes prescribed to help "dead hair" fall out so new hair can grow.)

Curious, how did you use the 1-ad?

I've already started back into my oatmeal routine every morning.

Is there a 7 alpha methyl nandrolone thread yet? Should I start one? :)
Click to expand...

most of the hairloss while on accutane was a generalized thinning overall ,but more noticeable was the hairline receeding..hairline did not come back.

i used 1-ad at 400mg/day, incredible stuff, there is a reason it was banned by the fda. i really wish the nordiol was still around..no hairloss, good gains, and made my armpits smell great.

i had started many threads of 7 alpha methyl 19 nortestosterone over the past few months
 
i dont have the plat membership either..id rather spend my money on chicken breasts. lol
 
lanky said:
nizoral did nothing for me..i used it for over three years
Click to expand...
your not alone i did a google and researched it very well. seems alot of people said the same as you it did nothing. But on the other hand you claimed it nothing but you used it for 3 years,so just maybe you would have lost hair faster or lot more of it with out nizoral.I'm using it anyways becuase its cheap combination with t-gel just becuase it better then nothing i suppose
 
I use it about twice a week. My hair is thick as a rug (thank the lord!) but you can never be too careful! As Macro put, anymore than 2-3x weekly feels too harsh on my hair. Remember you CAN have too much of a good thing. Make sure to lather it up good and leave it in for about a minute or two. I follow it up with their conditioner which has a nice minty tingle to it, lol. Good luck.
 
chazk said:
your not alone i did a google and researched it very well. seems alot of people said the same as you it did nothing. But on the other hand you claimed it nothing but you used it for 3 years,so just maybe you would have lost hair faster or lot more of it with out nizoral.I'm using it anyways becuase its cheap combination with t-gel just becuase it better then nothing i suppose
Click to expand...

the debate on wheather nizoral has any effect on hairloss has become warped over the years...it is a dandruff and seborrheic keratosis shampoo. it has shown effetiveness in increasing hair diameter and thickness so to speak in the individuals with thinning due to those two conditions..not everyone with dandruff and sebum problems have thinning hair..the ones with severe problems can have hairloss....ketoconazole(the active ingrediant in nizoral shampoo) is also used as an antifungal that has been shown to have some anti androgen activity when taken ORALLY as a pill..it is very hepatoxic and its antiandrogenic effects are systemic involving not just 5 alpha reductase, in general it is not .

the following is not my writing:
The major drawbacks of ketoconazole therapy are from the occasionally seen adverse reactions. It may induce anorexia, nausea and vomiting [462, 591]. Increase in transaminase levels and hepatoxicity may occur [1318, 2338]. Ketoconazole may decrease testosterone and cortisol levels, resulting in gynecomastia and oligospermia in men and menstrual irregularities in women [1643, 2213].

The effects of ketoconazole on functions of the thyroid gland have also been investigated. There have been a number of reports suggesting that ketoconazole may have antithyroid function via impairment of thyroglobin iodination and iodothyrosine coupling. In vitro, ketoconazole has been found to form a complex with iodine and inhibit lactoperoxidase. In vivo experiments in rats have shown that the weight of thyroid gland increases in rats treated with ketoconazole [461]. In another study designed to investigate the influence of ketoconazole on the basal and TSH-stimulated iodide uptake in the rat thyroid cells, concentration-based variations were observed. Ketoconazole appeared to increase the basal iodide uptake slightly at lower concentrations, while it sharply decreased the uptake below the basal levels at higher concentrations. Under TSH stimulation, the inhibitory effect of the drug were observed even at low concentrations [1207]. In contrast to these animal data, studies carried on in a limited number of euthyroid, healthy individuals, hypothyroid patients, and patients with thyrotoxicosis failed to provide any data suggesting a potential inhibitory effect of ketoconazole on thyroid functions [530, 531]. These data suggest that possible antithyroid effect of ketoconazole demands further investigation and close follow-up.

that is in oral administration
 
Oral ketoconazole has been demonstrated to lower plasma testosterone in man. Measurement of blood precursors of testosterone suggest that ketoconazole may have its effect inhibiting the 17,20-desmolase enzyme within the testis. To substantiate this, a series of in vitro experiments was conducted using the rat testis to determine where in the testosterone biosynthetic pathway ketoconazole has its effect. To accomplish this, an assay system to measure 17 alpha-hydroxylase, 17,20- desmolase, and 17 beta-hydroxysteroid dehydrogenase activities involved in the delta 4-testosterone biosynthetic pathway was developed. It was demonstrated from dose-response and time-course experiments that a dose of approximately 10 micrograms/ml ketoconazole was sufficient to inhibit in vitro testicular steroidogenesis. Using dosages between 10 and 300 micrograms/ml ketoconazole, a marked inhibition of both the 17 alpha-hydroxylase and the 17,20-desmolase activities occurred. Ketoconazole under these conditions had no effect on 17 beta- hydroxysteroid dehydrogenase activity. Ketoconazole also inhibited the increased activity of these enzymes induced by hCG (1 IU). These data confirm the observation that in vitro ketoconazole has a direct inhibitory effect on 17,20-desmolase activity. These results further suggest that ketoconazole has more than one site of action in inhibiting testosterone biosynthesis in the testis and may indeed be a suitable agent for the treatment of patients with disseminated prostate cancer.
 
nizoral works topically, by blocking the AR in the scalp. Its not perfect but it does afford some protection. it could be better formulated for this purpose. However applying to warm wet scalp and leaving in for 3-5 minutes does have decent effect.

there are other anti-androgens that can be used topically that may be better suited, however formulation and base carrier are lacking at this time.

expect that they will develop a SARM, oral or injectable, that will eventually address this issue. big pharma would be stupid to not be looking at this (though they would also be stupid to let anyone know)
 
glennds said:
this stuff sounds like snake oil. think about it. shampoo is on your hair and scalp a matter of seconds before you rinse it down the drain.

dont see it can possibly keep your hair from falling out. can it magically absorb into your scalp for the few seconds you use it and stop hair loss? now propecia, which is taken internally or rogain, which is left on the scalp, could be effective.

shampoo is soap. wont stop your hair from falling out. wont turn your fine hair into a full head of hair. wont change unruly locks into a manageable head of hair. we are all suckered in by marketing.
Click to expand...

You are correct, I doubt if a few seconds would have much of an effect.
Every day and leave it sit on your scalp for 4-5 minutes. I put it on, shave, and then shower. Ketoconozole has been shown to inhibit the synthesis of DHT by preventing some pathways of steroid synthesis.

I agree with others in this thread, us a high quality conditioner. I like Aussie for dry / damaged hair.
 
lanky said:
i was correct....100% beta reduced...no 5 alpha isomer metabolites detected
Click to expand...
really? i heard it has weak affinity for 5AR; didnt know it was zero. does it have strong affinity for 5B? i wonder how much of EQ's anabolism is due to the 5B 1-Test analogue.

1-ad was awful on my hair too. EQ wasnt, but i didnt get an itch later on in the cycle.
 
thebrakes said:
really? i heard it has weak affinity for 5AR; didnt know it was zero. does it have strong affinity for 5B? i wonder how much of EQ's anabolism is due to the 5B 1-Test analogue.

1-ad was awful on my hair too. EQ wasnt, but i didnt get an itch later on in the cycle.
Click to expand...

all good questions.i wish i could give you an answer.i will have to look up more info on this..back to the books..i have info on every metabolite of every steroid, and the ratio between them..even a few rare ones. single administration study though..interestingly a few steroid ratios of metabolites can change during prolonged administration, just off hand this was noted with 17 alpha methyl DHT(mestanolone), popular by german olympic athletes in the early 1980"s..If you visit the science,biology and pharmacology section of EF you will find one of my posts i cut from a secret german doping program(no so secret anymore)(basicly talks about T-bol, mestanolone, and german athletes)..some girls that were training in the olympics were given AAS at as young as 9 years old.
 
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