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First myostatin blocker product out there! Soon I hope other products like that will follow with better and better stuff.
Myostatin blocker allows you to have CONTINUOUS UN ENDING muscle growth. So in theory and in animal studies, you can double your muscle mass even without training!
Imaging popping few pills and becoming 300 pound ripped to shreads without training! Ofcourse this is a bit far fetched (5 years perhaps), but the basics are here! woohaa!!!
Anyone tried it? Lets see how well it works!!! ANy comments?
What is MyoStim?
MyoStim is the World's first publicly available myostatin binder. Myostatin is a peptide (a small chain of amino acids like a miniature protein) that is made in muscle cells. It is the primary regulator of muscle growth in the body. In other words, it stops muscle growth. Research has shown that if myostatin is blocked, muscles begin growing almost without limit - and without ever plateauing! Although MyoStim is still a research product for Champion Nutrition, we intend to show that it will partially interfere with the ability of myostatin to stop muscle growth - we believe it will remove the genetic roadblock most of us have to growing muscle. If this is true then it is the most exciting advance in the history of bodybuilding. Finally, the things we do like training, taking protein, etc, will actually make us big... without steroids! Now a little more technical information: The active myostatin binder in MyoStim contains a low molecular weight Polysaccharide (a chain of sugar molecules like a starch, only smaller) with a unique natural biochemical function group (this is completely assembled by the living plant) that make it a very special molecule. In fact, similar compounds isolated from similar plants had zero myostatin binding affinity. This active natural ingredient in MyoStim binds myostatin more strongly than the chemical binder that the original researchers used in their research to isolate myostatin in the first place! This is really cool!
What evidence do we have that our myostatin binding component (MBC) should work?
Since there is not direct human research yet with MyoStim (which is why we are asking for people to try it), what evidence do we have that it ought to work? To make a case for MyoStim we should be able to show five things:
We need to show that MyoStim contains something that binds myostatin.
We need to show that it binds myostatin very strongly.
We need to show that a significant amount gets into tissues when taken by mouth
We need to show that binding myostatin is a valid way of inhibiting it.
We need to show that reducing myostatin activity has an effect on muscle growth.
Here is how we answer those five requirements:
Electophoresis studies proved that our MyoStim contains an active component that binds tightly with myostatin in muscle tissue extracted from animals.
Chromatography studies proved that MyoStim binds even more strongly (has a higher binding affinity) than the best binder used in myostatin research! And the binder used in most research is toxic; MyoStim is not.
Research on animals showed that a significant amount of the myostatin binding component (MBC) in MyoStim passes through digestion and gets through the liver intact (MBC was given by mouth to mice and later extracted from various peripheral tissues, intact, in significant amounts). Look for more information about these studies in future updates.
A recently published study proved that binding myostatin is a valid way to prevent myostatin from blocking muscle growth (see reference study).
Finally, we know that controlling myostatin has dramatic effect on muscle growth (see hamster photos )
How long will it take to work?
The mice were under myostatin control for a period of a year or so! We believe myostatin binding is something you should start using as soon as possible in your bodybuilding life and stay on it until you are so big that you can't wipe yourself... then back off just a little... please. But seriously, this is something that takes time. Myostatin suppression doesn't make you grow, it removes the roadblock to growth - and then the natural tendency of muscle is to grow constantly.
If my muscles won't bulge right away what will I notice?
You will notice that you feel tighter and more pumped when you wake up in the morning.
You'll notice less soreness and inflammation in the muscles (because the myoblasts should be covering micro-tears and reducing white blood cell involvement more about this in the next update).
You'll notice you seem to recover a little better.
You should start looking more lean and defined.
Within a month you should be able to measure growth.
How do I take it?
Take it four times a day on an empty stomach and don't eat anything for ½ hour. Time doses so that you train about an hour after taking it.
Do not over-train. In fact you might be better off reducing your training intensity (don't do forced reps) and reduce the sets and reps by about 30% and see if you grow better after a couple weeks. This is all just a guess. We'll know more once we start getting feedback.
If you become part of our research project you must (I repeat), you must fill out our questionnaire every time we send it (about once a month). This is vital to our study. Keep track of your body fat if you can. Weigh yourself. Measure.
Will the body acclimate to myostatin binders?
No, it doesn't appear that you will acclimate to myostatin Binders. One of the most recent studies on myostatin informally established this fact. He induced high levels of a peptide that inhibits myostatin binding with the myostatin receptor site in hamsters. Over the life of the hamsters they continued to grow just as if they had been genetically altered to be incapable of making myostatin. So, although more research is needed it doesn't look like up-regulation of myostatin will occur. In other words the body does not appear to acclimate to myostatin.
If I stop taking myostatin binders will my muscles disappear?
We believe muscle size will not go away when you stop taking myostatin binders. When an athlete stops taking steroids, muscles shrivel. But steroids do not work like myostatin binders. It appears that reducing myostatin activity, even in mature animals, results in new muscle cells being formed! Consequently, it should be relatively easy to keep your muscle if you ever stop taking myostatin Binders. But why would you want to stop? The real benefit comes with staying on them throughout your bodybuilding career. I think the part of the muscle gains that come from making new muscle cells will stay permanently. This may be more than 50% of the muscle you gain!
Will it cause heart muscle or smooth muscle to grow the same as it does for skeletal muscle?
No. Myostatin is quite specific for skeletal muscle. Even on animals who have 100% inhibition of myostatin there are minimal direct effects seen on the heart or on smooth muscle. This was one of the first things we were concerned about. It does appear to improve strength and recovery of cardiac tissue just a little, but it certainly doesn't cause the kind of massive hypertrophy seen in skeletal muscle or else the little hamster's chests would have exploded half-way through the experiment!
How about other side-effects?
Because myostatin is so specific, it only stimulates one enzyme and that enzyme is specific for the inhibition of one muscle protein, it has no other known effects in the body. Because it is natural, coming from sea vegetables, it is the ultimate solution for vegetarians and principled people who want to grow naturally.
What are the arguments against myostatin regulation?
Polysaccharide absorption
Some people would argue that polysaccharides couldn't be absorbed. There is plenty of evidence of low molecular weight polysaccharides and muco-polysaccharides (a polysaccharide with a protein hooked to it) moving through tissues, especially when they have modified functional groups like, in our case, sulfur groups (done by mother nature of course). In the case of our particular low molecular weight polysaccharide there is specific research evidence to show that it not only gets absorbed, but that it passes through the liver and gets into tissues in an intact form. Since the study is not yet published we are going off of the statements of the research team that provided our samples, but they are an established research group that would have a lot to lose if they were stretching the truth. Soon their study will be presented and we will post it on our web site.
Embyological importance only
Although there aren't many people left who would still argue this point you still here it from time to time from people who haven't kept up on the latest research. These people state that myostatin only plays a role during embryological development and that raising or lowering its activity has only small effects on normal adult mammals. This has been debunked by several studies that show the direct effects of myostatin on the creation of new muscle cell nuclei (which allows muscle cells to get larger) and on the direct regulation of protein synthesis in adult mammals. But the most important new study shows that inhibiting myostatin appears to stimulate the formation of new muscle cells by causing dramatic division of Satellite cells! These Satellite cells differentiate into Myoblasts. If myostatin levels stay low then the Myoblasts form new muscle membranes and nuclei - these result in new muscle cells! Not just a few cells, but thousands! And they just keep coming - you don't run out of Satellite cells because they just keep dividing as long as myostatin levels stay down! This is revolutionary because it was always thought that very little new cells could be created after birth - true, until they inhibited myostatin! This is also where the confusion about the role of myostatin in adult muscle cells came about - they use to think that Myoblasts and Satellite cells only played embryological roles. Myostatin's role in disease is currently being assessed; it appears to be up-regulated in wasting disorders as we said earlier.
Flash - Fast breaking news just before publishing!
The eternal question: Do muscle cells divide or just get bigger?
Just before this went on the web we got hold of a study that answered the question that has been nagging muscle researchers for 30 years: Under the right influences can you force muscle cells to divide? This new research shows that by controlling myostatin you can actually do something even better!! When you suppress myostatin prior to training three things happen:
Satellite cells begin dividing rapidly - when myostatin is suppressed
Satellite cells used to be thought of as just embryonic cells that played little role in the adult. Now they are know to be the key to muscle growth!
Satellite cells convert to Myoblast cells
Myoblasts become very active - when myostatin is suppressed
Myoblasts bind to muscle cells and add new nuclei to the muscle cell - this is what allows a mature muscle cell to grow bigger (the size of a muscle cell is directly related to the number of nuclei it has).
Myoblasts begin producing microtubules that form the membranes of brand new muscle cells!
Myoblasts add nuclei to these microtubules and a new muscle cell is born!
First myostatin blocker product out there! Soon I hope other products like that will follow with better and better stuff.
Myostatin blocker allows you to have CONTINUOUS UN ENDING muscle growth. So in theory and in animal studies, you can double your muscle mass even without training!
Imaging popping few pills and becoming 300 pound ripped to shreads without training! Ofcourse this is a bit far fetched (5 years perhaps), but the basics are here! woohaa!!!
Anyone tried it? Lets see how well it works!!! ANy comments?
What is MyoStim?
MyoStim is the World's first publicly available myostatin binder. Myostatin is a peptide (a small chain of amino acids like a miniature protein) that is made in muscle cells. It is the primary regulator of muscle growth in the body. In other words, it stops muscle growth. Research has shown that if myostatin is blocked, muscles begin growing almost without limit - and without ever plateauing! Although MyoStim is still a research product for Champion Nutrition, we intend to show that it will partially interfere with the ability of myostatin to stop muscle growth - we believe it will remove the genetic roadblock most of us have to growing muscle. If this is true then it is the most exciting advance in the history of bodybuilding. Finally, the things we do like training, taking protein, etc, will actually make us big... without steroids! Now a little more technical information: The active myostatin binder in MyoStim contains a low molecular weight Polysaccharide (a chain of sugar molecules like a starch, only smaller) with a unique natural biochemical function group (this is completely assembled by the living plant) that make it a very special molecule. In fact, similar compounds isolated from similar plants had zero myostatin binding affinity. This active natural ingredient in MyoStim binds myostatin more strongly than the chemical binder that the original researchers used in their research to isolate myostatin in the first place! This is really cool!
What evidence do we have that our myostatin binding component (MBC) should work?
Since there is not direct human research yet with MyoStim (which is why we are asking for people to try it), what evidence do we have that it ought to work? To make a case for MyoStim we should be able to show five things:
We need to show that MyoStim contains something that binds myostatin.
We need to show that it binds myostatin very strongly.
We need to show that a significant amount gets into tissues when taken by mouth
We need to show that binding myostatin is a valid way of inhibiting it.
We need to show that reducing myostatin activity has an effect on muscle growth.
Here is how we answer those five requirements:
Electophoresis studies proved that our MyoStim contains an active component that binds tightly with myostatin in muscle tissue extracted from animals.
Chromatography studies proved that MyoStim binds even more strongly (has a higher binding affinity) than the best binder used in myostatin research! And the binder used in most research is toxic; MyoStim is not.
Research on animals showed that a significant amount of the myostatin binding component (MBC) in MyoStim passes through digestion and gets through the liver intact (MBC was given by mouth to mice and later extracted from various peripheral tissues, intact, in significant amounts). Look for more information about these studies in future updates.
A recently published study proved that binding myostatin is a valid way to prevent myostatin from blocking muscle growth (see reference study).
Finally, we know that controlling myostatin has dramatic effect on muscle growth (see hamster photos )
How long will it take to work?
The mice were under myostatin control for a period of a year or so! We believe myostatin binding is something you should start using as soon as possible in your bodybuilding life and stay on it until you are so big that you can't wipe yourself... then back off just a little... please. But seriously, this is something that takes time. Myostatin suppression doesn't make you grow, it removes the roadblock to growth - and then the natural tendency of muscle is to grow constantly.
If my muscles won't bulge right away what will I notice?
You will notice that you feel tighter and more pumped when you wake up in the morning.
You'll notice less soreness and inflammation in the muscles (because the myoblasts should be covering micro-tears and reducing white blood cell involvement more about this in the next update).
You'll notice you seem to recover a little better.
You should start looking more lean and defined.
Within a month you should be able to measure growth.
How do I take it?
Take it four times a day on an empty stomach and don't eat anything for ½ hour. Time doses so that you train about an hour after taking it.
Do not over-train. In fact you might be better off reducing your training intensity (don't do forced reps) and reduce the sets and reps by about 30% and see if you grow better after a couple weeks. This is all just a guess. We'll know more once we start getting feedback.
If you become part of our research project you must (I repeat), you must fill out our questionnaire every time we send it (about once a month). This is vital to our study. Keep track of your body fat if you can. Weigh yourself. Measure.
Will the body acclimate to myostatin binders?
No, it doesn't appear that you will acclimate to myostatin Binders. One of the most recent studies on myostatin informally established this fact. He induced high levels of a peptide that inhibits myostatin binding with the myostatin receptor site in hamsters. Over the life of the hamsters they continued to grow just as if they had been genetically altered to be incapable of making myostatin. So, although more research is needed it doesn't look like up-regulation of myostatin will occur. In other words the body does not appear to acclimate to myostatin.
If I stop taking myostatin binders will my muscles disappear?
We believe muscle size will not go away when you stop taking myostatin binders. When an athlete stops taking steroids, muscles shrivel. But steroids do not work like myostatin binders. It appears that reducing myostatin activity, even in mature animals, results in new muscle cells being formed! Consequently, it should be relatively easy to keep your muscle if you ever stop taking myostatin Binders. But why would you want to stop? The real benefit comes with staying on them throughout your bodybuilding career. I think the part of the muscle gains that come from making new muscle cells will stay permanently. This may be more than 50% of the muscle you gain!
Will it cause heart muscle or smooth muscle to grow the same as it does for skeletal muscle?
No. Myostatin is quite specific for skeletal muscle. Even on animals who have 100% inhibition of myostatin there are minimal direct effects seen on the heart or on smooth muscle. This was one of the first things we were concerned about. It does appear to improve strength and recovery of cardiac tissue just a little, but it certainly doesn't cause the kind of massive hypertrophy seen in skeletal muscle or else the little hamster's chests would have exploded half-way through the experiment!
How about other side-effects?
Because myostatin is so specific, it only stimulates one enzyme and that enzyme is specific for the inhibition of one muscle protein, it has no other known effects in the body. Because it is natural, coming from sea vegetables, it is the ultimate solution for vegetarians and principled people who want to grow naturally.
What are the arguments against myostatin regulation?
Polysaccharide absorption
Some people would argue that polysaccharides couldn't be absorbed. There is plenty of evidence of low molecular weight polysaccharides and muco-polysaccharides (a polysaccharide with a protein hooked to it) moving through tissues, especially when they have modified functional groups like, in our case, sulfur groups (done by mother nature of course). In the case of our particular low molecular weight polysaccharide there is specific research evidence to show that it not only gets absorbed, but that it passes through the liver and gets into tissues in an intact form. Since the study is not yet published we are going off of the statements of the research team that provided our samples, but they are an established research group that would have a lot to lose if they were stretching the truth. Soon their study will be presented and we will post it on our web site.
Embyological importance only
Although there aren't many people left who would still argue this point you still here it from time to time from people who haven't kept up on the latest research. These people state that myostatin only plays a role during embryological development and that raising or lowering its activity has only small effects on normal adult mammals. This has been debunked by several studies that show the direct effects of myostatin on the creation of new muscle cell nuclei (which allows muscle cells to get larger) and on the direct regulation of protein synthesis in adult mammals. But the most important new study shows that inhibiting myostatin appears to stimulate the formation of new muscle cells by causing dramatic division of Satellite cells! These Satellite cells differentiate into Myoblasts. If myostatin levels stay low then the Myoblasts form new muscle membranes and nuclei - these result in new muscle cells! Not just a few cells, but thousands! And they just keep coming - you don't run out of Satellite cells because they just keep dividing as long as myostatin levels stay down! This is revolutionary because it was always thought that very little new cells could be created after birth - true, until they inhibited myostatin! This is also where the confusion about the role of myostatin in adult muscle cells came about - they use to think that Myoblasts and Satellite cells only played embryological roles. Myostatin's role in disease is currently being assessed; it appears to be up-regulated in wasting disorders as we said earlier.
Flash - Fast breaking news just before publishing!
The eternal question: Do muscle cells divide or just get bigger?
Just before this went on the web we got hold of a study that answered the question that has been nagging muscle researchers for 30 years: Under the right influences can you force muscle cells to divide? This new research shows that by controlling myostatin you can actually do something even better!! When you suppress myostatin prior to training three things happen:
Satellite cells begin dividing rapidly - when myostatin is suppressed
Satellite cells used to be thought of as just embryonic cells that played little role in the adult. Now they are know to be the key to muscle growth!
Satellite cells convert to Myoblast cells
Myoblasts become very active - when myostatin is suppressed
Myoblasts bind to muscle cells and add new nuclei to the muscle cell - this is what allows a mature muscle cell to grow bigger (the size of a muscle cell is directly related to the number of nuclei it has).
Myoblasts begin producing microtubules that form the membranes of brand new muscle cells!
Myoblasts add nuclei to these microtubules and a new muscle cell is born!
