Yup, I can lift with it no problem. Doesn't bother me, doesn's scratch, doesn't pinch, nothing.
The band is not thick or wide, and I only have my e-ring now, not a wedding band. Maybe when both are on my hand I will have to take them off. Who knows. But it doesn't bother me in the least to lift with it. And I am not worried about losing a stone, if it is going to happen, it will happen - in the gym or out. It's not like I am running around willy-nilly slamming the ring into weights and machines. I don't have diamonds all around the band either, and don't plan on having that for my wedding ring either.
And as far as an active lifestyle, it does not mean just the gym. The gym is actually a small part of my activity - the rest is working with children.