More cortisol and fat; SPAT

[wilson6]

SPAT,

Just reviewed a paper by Elbers AJP 1999 looking at the effects of sex steroids on body composition in transsexuals. Interesting that not only did E and P administration increase both visceral and sub-Q body fat (Ab, Hip and thigh) in the guys to chicks (reverse happened with chicks to guys) except for the visceral fat (increased in both groups), but in the M-F trannys, their 24 hr urinary cortisol excretion increased significantly with E and P treatment and remained elevated for the duration of the study (12 months). No change in the F-M. Sort of interesting. Still wonder where it is coming from and what comes first.

The study on the anorexics confirms what I was saying about the peripheral vs visercal fat accumlation with elevated cortisol (cortisol causing peripheral lipolysis but central lipogenesis).

You might also want to check out a paper by Stumvoll, J Clin Endocrinol Metab 85: 3720, 2000. Looked at the effects of insulin on supression of systemic, intramuscular and sub-Q lipolysis.

W6

 

[Debu]

There's an article in the May GQ magazine about a man becoming a woman, he was taking premarin and spironolactone. He said the first notciable effct was called fat migration. He used to carry fat in his chin, cheeks, and belly his lost fat in those places and gained fat on his hips and buttocks. His breasts became a B cup. Now why couldn't I in high school get this to grow some boobs? Anyhow, he also had a surgery to "invert" his penis, whatever that is? Don't know if I'm off topic on this one but guess it's a coincidence that I just read it.

 

[wilson6]

F-M trannys don't take E and P. In fact, the E levels remain the same either way assuming one is comparing pre-post in early follicular phase.

F-M only take testosterone (250 mg Sus every two weeks).

The M-F take E and an anti-androgen that may or may not have progestagenic activity.

W6