Leptin!

[nandi12]

Bromo is supposed to increase leptin isn't that what that new bromo book was about

I was going to deliver my usual cynical diatribe, but just to surprise georgie24 I'll be more upbeat. I have not read Lyle McDonald's book but I don't think it is leptin that dopamine is supposed to be targeting. Rather, bromocriptine, a dopamine agonist, "can reverse many of the metabolic alterations associated with obesity by resetting hypothalamic circadian organization of monamine neuronal activities" to quote the researchers at Ergo Science who pioneered this research.

What these guys noticed was that if bromocriptine is given to animals that usually store fat and then hibernate, they no longer store fat. Evidently this circadian fat storage phenomenon is somehow regulated by dopaminergic neuronal transmission. Leptin is not involved because when bromocriptine is administered to obese mice engineered to lack leptin, the mice still lose weight.

The Ergo people reasoned that humans might have a similar mechanism of fat storage and tried it on people. It seemed to work. Here is the relevant abstract:


Diabetes Care 1996 Jun;19(6):667-70

Bromocriptine (Ergoset) reduces body weight and improves glucose tolerance in obese subjects.

Cincotta AH, Meier AH.

Ergo Science, Charlestown, Massachusetts 02129, USA.

OBJECTIVE: A double-blind placebo controlled study investigated long-term effects of Ergoset, a new quick release formulation of bromocriptine, on body weight, body fat, and glucose tolerance in a group (n = 17) of obese subjects who were instructed to follow a moderate hypocaloric diet. RESEARCH DESIGN AND METHODS: Obese individuals (> 25% body fat for men and > 30% body fat for women) were instructed to follow a calorie-restricted diet (70% of weight maintaining based on study entry weight) and were randomized to daily treatment with Ergoset (1.6-2.4 mg/day) or placebo at 0800 over an 18-week treatment period. Oral glucose tolerance tests were performed on subjects before initiation and again at termination of treatment. Body weight and body fat (determined by skinfold measurements) were quantified every 2 weeks during the course of treatment. RESULTS: Ergoset treatment for 18 weeks significantly reduced body weight and body fat versus placebo (6.3 +/- 1.5 and 5.4 +/- 1.1 kg vs. 0.9 +/- 1.0 and 1.5 +/- 0.6 kg. respectively, P < 0.01). Ergoset, but not placebo, also improved glucose tolerance (P < 0.02); the stimulated area under the oral glucose tolerance curve was reduced by 46% (from 121 +/- 23 to 64 +/- 32 mg.h-1.dl-1), while the stimulated area under the insulin curve was reduced by 30%. CONCLUSIONS: When combined with instruction to follow a moderate hypocaloric diet, Ergoset, but not placebo, improves glucose tolerance and promotes significant weight and body fat loss in obese subjects over an 18- week treatment period.

 

[bigrand]

Well shit Nandi, im sorry but im not as educated in the topic as you are. Im not looking for a free lunch, just a better understanding of Leptin and how it works. I was confused as to if it was a good thing or a bad, but it seems to have its positives and negatives as well. Havent you ever been confuse, or are you too smart for that?
Im still in JC right now with some micro/chem/ect background, not a WHOLE lot, so ya think you could cut me a break?

 

[nandi12]

Havent you ever been confuse, or are you too smart for that

I get confused all the time, especially when I expect things to make sense. Most of the time it seems like when things make sense your understanding of some process is too simplistic. Usually the cause of this is that you have been tricked into thinking that someone's explanation for a particular observation is the correct explanation when in fact it is really just a hypothesis. When someone comes along with a different explanation (hypothesis), the natural reaction is to think "Wait a minute, this contradicts everything I thought I knew before. Now I'm really confused."

If you want to simulate the effects of leptin while you are waiting for it to be approved, there are some things out there. Basically, leptin's two actions that have been thus far identified as promoting weight loss are appetite suppression and in increase in basal oxygen consumption reflecting an increase in metabolic rate (more fat burning). Meridia is pretty good at suppressing appetite, while T3 certainly increases basal metabolic rate (BMR). The disadvantage of T3 in raising BMR is that, unlike with leptin, it seems to come at the expense of lean body mass as well as fat mass. A little anabolic steroid thrown into the mix will solve that problem.

 

[kbp74]

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[Par Deus]

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[Par Deus]

Bromo does not increase leptin (or at least that is not its main mechanism of action), rather Lyle proposes that it (or dopamine) mimicks leptin -- i.e. it lies downstream of leptin signalling and mediates its actions.

My opinion is that is a bit less important than Lyle argues -- basically, that it is just another one of the numerous signals involved in adipostatic control, which are influenced by leptin, thus while it mimicks some of its effects, it does not mimick all of them -- retention of LBM and increase in BMR above basal levels, being two of the more important actions it lacks vs. leptin.

 

[Scatocephalus]

Would using bromo in conjunction with a product like Avant's LeptiGenl be a good idea then? How about adding in T3?

 

[Dante B.]

Using LeptiGen could allow a lower-dose use of Bromo. Increasing Leptin levels, will increase T-3/Thyroid output; however, T-3 can still be added, if wished.

 

[George Spellwin]

<p><strong><img src="http://www.elitefitness.com/images/diet-drugs/pramlintide-metreleptin.jpg" alt="Pramlintide Metreleptin" width="300" height="447" hspace="10" align="right" /><a href="http://bodybuilding.elitefitness.com/pramlintide-metreleptin-diet-drug" target="_blank">Pramlintide & Metreleptin Injectable Diet Drug Combo Promotes Massive Weight Loss</a></strong></p> <p>Every new diet drug that comes out is supposedly the next big thing.  However, two new drugs have the potential to shake up the dieting industry. They are Pramlintide and Metreleptin and it appears they can help people drop more pounds than ever before.  And the best part is that they’ll work on burning fat without you having to lift a finger! </p> <p> Weight loss expert Dr. Ken Fujoka stated this fact when he said, “With these new medications, now we're getting what we call double digit weight loss. 10 percent and up.”  Fujoka continued by saying, “So now you're losing 20, 30, and 40 pounds of weight with these new weight loss medications, which really makes the doctor and the patient a lot happier.”</p> <p>The Pramlintide and Metreleptin combo drug that is allowing people to see these double digit losses in weight is made by a company called Amylin.  Their injectable drug doesn’t have a name yet, but it has proven to curb people’s appetites in clinical trials. </p> <p>Here's the link to the full article:</p> <p><a href="http://bodybuilding.elitefitness.com/pramlintide-metreleptin-diet-drug" target="_blank">Pramlintide & Metreleptin Injectable Diet Drug Combo Promotes Massive Weight Loss</a></p>

 

[Shaiblake7]

Hi guys anyone knows how or where i can get leptin injections
Anything will help