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genezapharmateuticals
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Research Chemical SciencesUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsResearch Chemical SciencesUGFREAKeudomestic

Humulin R or Humalog

AD, I have a question........since Humulin R is a slower releasing insulin, wouldn`t it be better for novices to use so that if a problem of low blood sugar begins there is plenty of time to remedy the problem ? I have had this happen a few times ( only have used Humulin R ) and it never seems to be at the same time after injection, very random...........but I can always feel it coming on slowly.
 
Actually that is the problem with "R". It can be much more bariable in its peaking time than humalog and this can cause un-expected low blood sugar episodes. One day it might peak at 45 min, another 2 hours later....many factors influence the absorption and activity so the least amount of time you can have the stuff in your system the better.

In terms of the quickness with which Humalog may cause low blood sugar, this will only become a problem when you wait too long to eat or don't eat enough. You still have time enough to catch it if you are aware though. Just don't wait to eat with Humalog, even for five or ten minutes, because it will take about 10 minutes for the carbs to really start getting into your blood. So if you waited ten minutes, then ate some carbs, it is still POSSIBLE to have low blood sugar because by the time the sugar gets into your bloodstream, its really been about 20 min and the humalog will already be active. Take your dose, eat carbs, then eat a balance meal of carbs, protein and fats- AND BE CAREFUL- AD
 
IG, I have taken to using humalog mostly for the convenience. Anymore, I use insulin only to complement GH, so the timing is real easy. a shot of each at the same time, and they peak and disapate in tandom. As AD said, slower insulins are unpedictable, and require one to wait too long for a proper meal. I have spiked in very inconvenient places on Humulin-r, and I'm sure you guys have also.
However, if you are using insulin alone with steroids for its anabolic properties, there is some pretty good arguments for using the slower types. In fact, some of the top people in the business, use a combination of very slow 12 hour insulins and fast acting ones. I am not disciplined enough in diet to get away with this, but am considering trying it this winter...these guys get real big.
What do you think, AD? I am very experienced with insulin, as you know.
Just got back from a trip to the heartland, all was good. How"s tricks, mechanic? MOD you old fart, drop me a note and tell me how it goes with you.
 
IronMaster, that's a very interesting question about the longer acting slin's. These may very well be warranted for those BB'ers who are doing "pro-type" cycles with very little if any time off. In their case, they are probably on the verge of being diabetic if not already there so supplementing with insulin is more of a requirement than a true supplement. Since their own beta cells won't be producing enough slin to counteract the effects of GH, androgens etc etc, a longer acting insulin with almost no peak would do well at aiding their Basal rate insulin(insulin levels between meals or fasting). Then for the Bolus insulin(meal insulin), they could also take a shot of humalog. This would no doubt raise their level of overall insulin and be more anabolic with respect to insulin levels in the body.

Now, with respect to the average guy, I would tend not to do the longer acting slin because your beta cells are probably not too overstressed(you would have symptoms) and if that is the case, a longer acting slin would actually inhibit your beta cells from producing insulin. This would lead to diabetes when you tried to get off the exogenous insulin. I personally think shorter acting slin is safer and any gain you might get from the longer acting insulins would be offset by the risks of hypoglycemia and becoming diabetic.

Hope all that was somewhat clear- I think I slipped into a siezure a couple of times while typing :D
 
Very clear, thanks. Nice to have you around, bro. I have thought about the risks with the super slow stuff, but I still may try it on a short term basis. I am real aware of the changes things make in my physique after all these years, so I think I could tell quickly. Might be a great plateau breaker, which I seem to be in right now.
Any serious risk in a short cycle? I have used 40iu of faster stuff (20 am and 20 pm)for short periods without problems, but am nowhere near that dose at present.
 
I honestly couldn't say what the REAL risks are. However, the slin you would want is either the "Ultralente" or the "lantus". I'm about to switch over to lantus from ultralente because the lantus has even less of a peak than the ultralente does. The "ultra" has a very small peak but sometimes you can notice it- this insulin works for 24hours! I'd go with the lantus though- same long acting type, just more even, consistent absorption.
 
Hey Ironmaster, im just reading the stack and its an interesting book to say the least. Thanks for your input and I can see where the longer acting slin would be more beneficial but the question is do I have the discipline as well as the time to continually get food down me. Now this gets more confusing. I had 3 pens of humalog and I swapped one for 1 pen of actrapid. So I have 2 humalogs and 1 actrapid. Have you used the pens? or do you use vials?

Thanks & Peace
 
Ok so can someone answer me this:

Act rapid

if you inject sub q, it starts working after 30 mins, peaks around 2 hrs & continues to exert and effect for 8 hours.

if you inject IV its onset is 5 mins and continues to exert and effect for 30 mins.

Now people recommend humalog for more predictability?

If IV therapy is easier to control and you can avoid overlaps where as with sub q it is easier to go into a state of hypoglycaemia why would it not be best to inject Act rapid IV?

Thanks
 
HERE YA GO

I did a search for ya Iron Game....I copied and pasted from several different posts some of the more interesting aspects of Slin...You will also find several discussed differences between the LOG and the -R....Hope it helps you....


Ok, lets have a look at insulin.
Its highly anabolic and non-androgenic, and in case some of you are in the dark (I'd like to think we're all clear on anabolic versus androgenic, but ya never know) I'll briefly touch on the subject before diving in... if youre ok on anabolic/androgenic concepts, skip to the INSULIN part...

ANDROGENIC VERSUS ANABOLIC
ANABOLIC is defined as "The process of constructive metabolism" or of building complex substances out of simple substances.
The way your body processes protien, carbohydrates, and fat (all simple substances) and makes muscle (a complex substance) is ANABOLISM.
ANDROGENIC is basically defined as pertaining to male sex characteristics.
ANDROGENIC/ANABOLIC
"Steroids" are actually called "Anabolic Androgenic Steroids." They accomplish "anabolism" through "anabolic" pathways, some being more androgenic (testosterone esters) and some less (winstrol, anavar, primobolan, ect...).
Most often, with reduced androgenic properties comes reduced anabolic properties, but it isnt always cut and dry. If anyone is interested I'll go into it another time, but lets head toward the insulin topic.

INSULIN: NonAndrogenic but Anabolic
Insulin is NOT a sex hormone. It is not related in any way to testosterone, or to estrogen for that matter. It is a product of the pancreas as opposed to testosterone which is a product of the HPTA, pituitary, gonadal, leydig, mishmash of interconnected glands...

WHY IS INSULIN ANABOLIC
So why is insulin anabolic then? Insulin is a partitioning agent. A "shuttle" if you will.
Picture insulin as a bus. Nutrients board the bus, and insulin pulls away and drops off the nutrients at the proper bus stop. That is basically what it does, and for all intents and purposes that is everything you need to know to understand how it works.
So by insulin shuttling these nutrient where they need to go, it enables anabolism and is therefor anabolic!

WHY NOT JUST TAKE CARBS TO RAISE INSULIN
Well, the amount of carbs you would need to take in to increase natural insulin levels to the degree a 10 i.u. shot would would be far more dangerous than using insuiln (and using insulin is NOT that hard OR dangerous).
Carbs at that level would eventually lead to diabetes and fat gains.
If insulin is a bus taking nutrients where they need to go, then exogenous insulin is a bullet train! It can hold far more nutrients than a normal naturally produced burst of insulin can, and it works quicker. Exogenous insulin is the most efficient way to accomplish glycogen overcompensation, period.

WHAT KIND DO I TAKE
Im a major supporter of fast acting insulin. The faster the better!
Currently he fastest acting insulin available is Humalog. It is active in 15 minutes, peaks in 1 hour and clears the system around 2 hours.
Next would be Humalin-R. It is active in about 30 minutes, peaks at the 2 hour mark, and clears the system at the 4 hour mark.
"Biophasics" are mixtures of fast and slow acting insulins, but are not the best choice in my opinion, due to an active dose being in you throughout the day. The reason you dont want that will be covered in the "HOW DO I USE IT" section.
There are also Humalin-L and Humalin-S, but they are long acting, and are no more use to me than the Biophasics. There are also porccine and bovine derived insulin, but I am against injecting animal derived substances.
WHEN (AND HOW MUCH) TO USE
Im going to assume we want to avoid any fat gains at all. Even bulking I dont like to gain any unneccesary fat, so Im going to disuss it from that stand point.
The ultra conservative time to use insulin is post-workout. Most people who are concerned about fat dont go over 10 i.u. as a total dose.
Some people us it on waking, before breakfast, since your body is in a basically carb depleted state. Its the kind of thng you have to try for yourslef, and if it works for you, do it. If you thnk youre gaining fat, stop. BUT! Dont start it at both times at once. Make sure you get your post workout dosage worked out and that you know it is not causing you any fat gains before you try pre-breakfast shots. That way you can take out all the guess work as to where any fat gains may come from.

DISPELLING A FEW MYTHS
There is a commoly held perception that you MUSt take in 10grams of carbs per I.U. of insulin, some radicals say 5 grams... well, theyre both wrong.
I got curious about this when I discovered that my insulin dependant diabetic friend didnt even keep track of what she ate post injection. She would feel hypoglycemic after a shot and take a Glucose Tablet.
A glucose tablet is only 5 grams of glucose (carbs)! So I started to think, "Hmmm, mabye everyone is off point on this?"
After conducting a few experiments on myself, I found that you can go considerably lower in carbs than people previously believed.
Now it doesnt make sense to go low in carbs, because that defies the purpose of using the insulin in the first place, but it does free us from having to use so much that there might be some "spill over" in carbs that cant be utilized. So it really makes us able to have more freedom in carbs choices and amounts.
The "risk" in insulin use is not as risky as people believe. Any person with an ounce of sense can see the warning signs of a problem coming, and remedy the situation.
HOW DO I DO IT
If you look at the drug store, you can get these little pen cases that hold a loaded insulin syringe. They are great for our need, you load up the syringe, and put it in the case, and throw it in your bag/purse/whatever. After the workout, head to a bathroom stall and inject it under the skin! Pull up a little skin from the abdomen or upper thigh (anywhere will do, but these are easiest) and inject. Do not shoot into a muscle. This rushes the dose and makes it harder to predict when it will spike.
So now you have 15 minutes to get some carbs (actually you have longer, since the initial hit of the dose is mild and easy to cope with, the spike is a little more harsh, but still nothing unbearable. If you use the carbs, you probobly wont notice the initial dose OR the spike.)
(this is based on Humalog at 10 i.u.)
I use a powder with a 20% simple/80% complex ratio (actually its 17% mono, 5% di, 7% tri, 5%tetra, and 66% penta-saccharides). I use about 60grams of carbs to the 10 i.u. of insulin.
This gives me a nice solid stream of carbs to overcompensate my depleted muscles, but not so many that I risk fat accumulation from the excess.
Now you are good to go till around 1 hour after the initial injection. At this 1 hour mark, the majority of the dose hits your system. Now is the time to eat a good balanced (AND FAT FREE!) meal. The fat-free emphasis will be explained in the POTENTIAL PROBLEMS section. This balance meal of carbs and protien and little to know fat can be anything from a protien drink and a crab drink, to a low fat MRP, to some lean chicken and rice... your choice.
After this meal, you dont need to pay anymore consideration to the insulin, it will gradually decrease and will be out of your system at the 2 hour mark.
Till you get accustmed to the use of insulin, start low and slow. Start at 2 i.u. then 5 i.u. then 7 i.u. then 10 i.u. That way you get a better understanding of any hypoglycemia you may encounter. Ive went as high as 35 i.u., just to try it, but at a certain point a higher dosage doesnt yield any better results (except fat!)
POTENTIAL PROBLEMS
Insulin is relativly safe. If you dont take in any carbs after using it, your body will give you PLENNTY of warning! Youll feel dizzy, tired, achey... hypoglycemic. What is happening is your body has no glycogen to use as fuel. Your muscles re depleted from working out, and often times youve tapped your liver for any remaining glycogen. The insulin does, searching for glycogen to use, takes the rest from your liver, and in the absence of carbs coming in to make more, it heads for the brain.
Your brain uses glucose as its primary fuel source (a little fat, too.) Thats why you get dizzy and light headed, the same with during a ketogenic diet... low glucose equals light headedness.
So if you forget about the carbs, youll get a warning from yuor body, and you can get your ass in gear and get some carbs in you.
If you get to the point where youre nauseated, just drink some sugary beverage and get some carbs in you quickly. Youre still a long long way from any major danger, but dont mess around.
"Fat Free" I said earlier about the 1 hour mark meal. During the 2 hours of the dosage duration, you should avoid fat like it is the plauge! Insulins partitioning properties are as effective at sending fat to the fat stores as it is carbs and protien to muscles!
So till the dose is clear of your system, NO FAT! (Thats another reason why I advocate the fastest acting insulin you can get.)

Well, I cant think of anything else off hand that needs to be said, but if I missed anything, just ask. I may have taken somethng for granted and figured everyone would know or assume on their own...
SO WHY BOTHER
Well, the carbs you take in after the shot are immediatly sent to your muscles to make up for the depleted state your workout put them in. At this point you are able to actually fill them with MORE glycogen than they could hold before the workout. This adds up to extra macro nutrients in the system for repairing the micro fiber damage done to the muscles.
The protien you take in at the 1 hour meal (and you can take in post workout protien shake after the carbs, too) will be preferentially sent where it is needed the most. So you can get those muscles rebuilt faster, and more efficiantly!
Thats also the reasoning behind the pre-breakfast dose.
Insulin is a hormone produced in the pancreas which helps to regulate glucose levels in the body. Medically, it is typically used in the treatment of diabetes. Recently, insulin has become quite popular among bodybuilders due to the anabolic effect it can offer. With well-timed injections, insulin will help to bring glycogen and other nutrients to the muscles.
In America, regular human insulin is available without a prescription by the name of Humulin R by Eli Lilly and Company. It costs about $20 for a 10 ml vial with a strength of 100 IU per ml. Eli Lilly and Company also produces 5 other insulin formulations, but none of these should be used by bodybuilders. Humulin R is the safest because it takes effect quickly and has the shortest duration of activity. The other insulin formulations remain active for a longer time period and can put the user in an unexpected state of hypoglycemia.
Hypoglycemia occurs when blood glucose levels are too low. It is a commonand potentially fatal reaction experienced by insulin users. Before an athlete begins taking insulin, it is critical that he understands the warning signs and symptoms of hypoglycemia. The following is a list of symptoms which may indicate a mild to moderate hypoglycemia: hunger, drowsiness, blurred vision, depressive mood, dizziness, sweating, palpitation, tremor, restlessness, tingling in the hands, feet, lips, or tongue, lightheadedness, inability to concentrate, headache, sleep disturbances, anxiety, slurred speech, irritability, abnormal behavior, unsteady movement, and personality changes. If any of these warning signs should occur, an athlete should immediately consume a food or drink containing sugar such as a candy bar or carbohydrate drink. This will treat a mild to moderate hypoglycemia and prevent a severe state of hypoglycemia. Severe hypoglycemia is a serious condition that may require medical attention. Symptoms include disorientation, seizure, unconsciousness, and death.
Insulin is used in a wide variety of ways. Most athletes choose to use it immediately after a workout. Dosages used are usually 1 IU per 10-20 pounds of lean bodyweight. First-time users should start at a low dosage and gradually work up. For example, first begin with 2 IU and then increase the dosage by 1 IU every consecutive workout. This will allow the athlete to safely determine a dosage. Insulin dosages can vary significantly among athletes and are dependent upon insulin sensitivity and the use of other drugs. Athletes using growth hormone and thyroid will have higher insulin requirements, and therefore, will be able to handle higher dosages.

Humilin R should be injected subcutaneously only with a U-100 insulin syringe. Insulin syringes are available without a prescription in many states. If the athlete can not purchase the syringes at a pharmacy, he can mail order them or buy them on the black market. Using a syringe other than a U-100 is dangerous since it will be difficult to measure out the correct dosage. Subcutaneous insulin injections are usually given by pinching a fold of skin in the abdomen area. To speed up the effect of the insulin, many athletes will inject their dose into the thigh or triceps.
Most athletes will bring their insulin with them to the gym. Insulin should be refrigerated, but it is all right to keep it in a gym bag as long as it is kept away from excessive heat. Immediately after a workout, the athlete will inject his dosage of insulin. Within the next fifteen minutes, he should have a carbohydrate drink such as Ultra Fuel by Twinlab. The athlete should consume at least 10 grams of carbohydrates for every 1 IU of insulin injected [Note, this is an older theory - take Monsters advice] . Most athletes will also take creatine monohydrate with their carbohydrate drink since the insulin will help to force the creatine into the muscles. An hour or so after injecting insulin, most athletes will eat a meal or consume a protein shake. The carbohydrate drink and meal/protein shake are necessary. Without them, blood sugar levels will drop dangerously low and the athlete will most likely go into a state of hypoglycemia.
Many athletes will get sleepy after injecting insulin. This may be a symptom of hypoglycemia, and an athlete should probably consume more carbohydrates. Avoid the temptation to go to bed since the insulin may take its peak effect during sleep and significantly drop glucose levels. Being unaware of the warning signs during his slumber, the athlete is at a high risk of going into a state of severe hypoglycemia without anyone realizing it. Humulin R usually remains active for only 4 hours with a peak at about two hours after injecting. An athlete would be wise to stay up for the 4 hours after injecting.
Rather than waiting to the end of a workout, many athletes prefer to inject their insulin dosage 30 minutes before their training session is over and then consume a carbohydrate drink immediately following the workout. This will make the insulin more efficient at bringing glycogen to the muscles, but it will also increase the danger of hypoglycemia. Some athletes will even inject a few IUs before lifting to improve their pump. This practice is extremely risky and best left to athletes with experience using insulin. Finally, some athletes like to inject insulin upon waking in the morning. After the injection, they will consume a carbohydrate drink and then have breakfast within the next hour. Some athletes find this application of insulin very beneficial for putting on mass, while others will tend to put on excess fat using insulin in this way.
Insulin use can not be detected during a drug test. For this reason, along with the fact that it is cheap and readily available, insulin has become a popular drug among the competitive athlete. However, before an athlete attempts to use insulin, he should educate himself and make himself aware of the consequences. One mistake in dosage or diet can be potentially fatal. [or you could get in a car wreck too]
Effective Dose: 1 IU per 10 - 20 lbs. of body weight
Humalog is the newest out, though. Newer than Humalin-R. Its now the fastest acting of the series.
To me, for minimal fat gains, the 1 i.u. for 10-20 lbs of bodyweight is a little high, but I know thats a safe guidline.


Nope, I dont use it on non training days, unless Im using it before breakfast. Then I still use it before breakfast even on nontraining days.
As far as the Humalin-R goes, yes eat at the 2 hour mark instead, and remember to keep the fat out of your diet for 4 hours, instead of 2!
and I forget to mention, if you take creatine..take it with the post shot carbs…

People who are naturally lean (bastards) have a lot more leeway with insullin. They dont have to worry so much about too much carbs, and be so anal about the fat intake...
Those BASTARDS!to mention it, but if you use creatine, take it with the post shot carbs.

Humalog is the best! Its hard to get sometimes, as they want a script for it a lot? I get "R" with no problem, but they want paper to get Humalog...
I have the diabetic girl I mention in the strory get it for me... she uses her insurance co-pay and 2 bottles run me $4.00

Most places will give you Humalin R with no script. But buy needles when you buy the insulin to avoid any problem with geting them. Familiarize yourself with them so you can just ask for them like you have used them before and you wont have any trouble. They dont see them the same as bigger gauss needles.
I think most states want a script for Humalog though. They feel that the rapid action of it has more dangers to the user.
(actually, a biophasic is more dangerous IMO. It spikes throughout the day as opposed to once like Humalog)


The only problem with using "cc" syringes is that dosing would be difficult!
50 I.U.'s is 1/2 a cc, so unless its the 1/2 cc insulin syringe (which WOULD be marked with specific I.U. marks), you should try to find the insulin ones. (unless youre talking about 1/2cc insulin syringes... you dont need the 3/10, just a syringe made for insulin)
When I used Humalin r, I bought it at Meijer (a grocery store, I dont know if its nation wide...). I asked for a bottle of Humalin R and 2 bags of BD 3/10" She asked if I wanted 27 or 29 gauge, to which I replied "Whatevers handy." and made my purchase.
If they ask you if you have insurance, just tell them "No". Theyll give it to you for a cheaper price than they charge the insurance companies most times...
You will have to start very low and work your way to a comfortable dosage of slin. Start with 2-3iu's and go up one unit at a time per day until you feel you've found a comfortable range. I would try the slin alone first to find some general tolerances before you use it with GH because GH will only complicate things if you haven't used before. Just a word of caution about Humalog- although it is out of your system faster which descreases the risks of hypoglycemia hours after your dose, if you mess up and get ballsy with a large dose, it will be hard to recover since it works so quickly- be careful.
I completely agree with AD.
Everybody has a different tolerance level and it can vary greatly so start low and work up until you are at your max. Trust me, you will know when you are. For me it was only 7iu. At 8 I started to feel hypo coming on and had to neck glucose fast. I was OK after 20 mins though.

Doing it before working out is about the stupidest thing you could do. Training lowers blood sugar levels anyway so you would have a much higher chance of going hypo. Take it immediately afterwards if you are going to. You can also take it in the mornings with your breakfast as long as you get enough carbs - provided your workout is in the afternoon. I'd only use it on training days when it is needed the most and for 4-5 weeks at the very most. The more you use it the more likely you are to become insulin resistant. I also would not advise it if your diet isn't clean or if you are already holding a lot of bodyfat as it will definately increase it.

How much research did you say you'd done?
I reckon you havn't done anywhere near enough.
Do some more, insulin WILL kill you immediately if you fuck up.
Listen to the strnegthmonster- he gave you some great info. Also don't forget to always have juice or glucose tablets with you while on slin- even if you think you're sure the dose is all gone. You don't want to get caught somewhere with unexpected low BS and no sugar- Good luck, keep us posted on how it goes; I'm sure you could help others out by documenting your experiences- AD
 
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