The undesired effect of growth hormones, the so-called side effects, are also a very interesting and hotly-discussed issue. Above all it must be said: STH has none of the typical side effects of anabolic/ androgenic steroids including reduced endogenous testosterone production, acne, hair loss, aggressiveness, elevated estrogen level, virilization symptoms in women, and increased water and salt retention. The main side effects that are possible with STH are an abnormally small concentration of glucose in the Wood (hypoglycemia) and an inadequate thyroid function. In some cases antibodies against growth hormones are developed but are clinically irrelevant. What about the horror stories about Acromegaly, bone deformation, heart enlargement, organ conditions, gigantism, and early death- In order to answer this question a clear differentiation must be made between humans before and after puberty. The growth plates in a person continue to grow in length until puberty. After puberty neither an endogenous hypersection of growth hormones nor an excessive exogenous supply of STH can cause additional growth in the length of the bones. Abnormal size (gigantism) initially goes hand in hand with remarkable body strength and muscular hardness in the afflicted; later, if left untreated, it ends in weakness and death. Again, this is only possible in pre-pubescent humans who also suffer from an inadequate gonadal function (hypogonadism). Humans who suffer from an endogenous hypersecretion after puberty and whose normal growth is completed can also suffer from Acromegaly. Bones become wider but not longer. There is a progressive growth in the hands and feet, and enlargement of features due to the growth of the lower jaw and nose. Heart muscle and kidneys can also gain in weight and size. In the beginning all of this goes hand in hand with increased body strength and muscular hardness; it ends, however, in fatigue, weakness, diabetes, heart conditions, and early death.