Maybe she should try Wellbutrin (bupropion) instead of Zoloft.
The antidepressants least likely to cause sexual side effects are Wellbutrin, Remeron and Serzone. In one study, no one taking Wellbutrin noted sexual side effects. If you and your doctor decide that the best antidepressant for you is an SSRI, you can still minimize your chances of sexual side effects. One approach, pioneered by psychiatrist Dr. Anthony Rothschild at McLean Hospital in Belmont, Mass., is to take weekends off the drug. He worked with 30 couples, one [person] of whom was taking an SSRI (Prozac, Paxil or Zoloft). They stopped taking their medication on Thursday morning and resumed Sunday at noon. Half of those taking Paxil and Zoloft noticed marked increases in libido and sexual satisfaction. But only 10 percent of Prozac users noticed any sexual benefit probably because compared with the other SSRIs, Prozac takes longer to clear from the blood.. Another approach to preventing SSRI-related sex problems may be to take the herb ginkgo [biloba] at the same time. In a recent study published in the Journal of Sex and Marital Therapy by researchers at the University of California at San Francisco Medical Center, 63 people experiencing sexual side effects from SSRIs, tricyclics and MAO inhibitors took ginkgo extract. Ninety-one percent of the women and 76 percent of the men noted improvement in sexual functioning. It's not clear why ginkgo helps reduce the sexual side effects of antidepressants.