HCGenerate, the nuts n' bolts of how it works?

[SWOLNUTZ]

So I was reading up on HCGenerate's ingredients and had a question on the ingredient, "3,4 - Divanillyltetrahydrofuran". This compound is reported to bind to Sex Hormone Binding Globulin (SHBG) in the scientific literature.

But my question is this, once it binds to SHBG, does it bind permanently? Or is it only bound for a certain length of time?

So if it does bind permanently, can we expect the free test levels to remain high until new SHBG replaces the old (bound) SHBG?

My thoughts, just from taking it, is that it must bind either permanently or for just a really long time, because if I take a few of the capsules, I notice it a lot for a day or so, then I can't tell much of an effect, unless I quit taking it for about a week.

That makes me think that after only a dose or so, the SHBG is essentially gone and there is no more SHBG to bind to.

Sorry for such a long post, but if anyone knows the specifics of how this works, please enlighten me.

-SWOLNUTZ

 

[JuiceIsMyFriend]

Bumping. I'm sure steve radar or needto can answer this

 

[moltomariodeca]

I just ordered 2 bottles of the HCgenerate, along with 2 bottles of unleashed and 2 of forged PCT. I'm would like to know the answer to this question also.


Very good question bro

 

[Mh48500]

Ditto.

 

[RickRock13]

I don't know the answer to your question exactly, but all compounds and ingredients have a life span that they are active and produce effects. What the life span or half-life of divanil is, I don't know, but that would probably be the length of time that it is bound to the SHBG. That would make sense to me, but I would still like a good scientific answer to this question.

NTBM Rep

 

[skeme]

Good question here

Sent from my SCH-I500 using EliteFitness

 

[TheSVPdeal]

Good question here

Sent from my SCH-I500 using EliteFitness

The idea isn't to take one dose but to take the product over an extended period of time. During that time, SHBG is low and free test is high. HCGenerate also stimulates new testosterone production. This combination, over that period of time, simulates natural production while supplementing or regenerates if during PCT. As the poster above states, everything has a life span. Consistent and continued use is necessary. Hope this logic helps a little.

 

[needtogetaas]

J Nat Prod. 1998 Jan;61(1):119-21. Related Articles, Links


Lignans interfering with 5 alpha-dihydrotestosterone binding to human sex hormone-binding globulin.

Schottner M, Spiteller G, Gansser D.

Lehrstuhl fur organische Chemie, Universitat Bayreuth, Germany.

The natural lignans (-)-3,4-divanillyltetrahydrofuran (1), (-)-matairesinol (2), (-)-secoisolariciresinol (3), (+/-)-enterolactone (4), (+/-)-enterodiol (5), and nordihydroguaiaretic acid (NDGA) (6) reduce the binding of 3H-labeled 5 alpha-dihydrotestosterone (DHT) to human sex hormone-binding globulin (SHBG). (-)-3,4-Divanillyltetrahydrofuran (1) has the highest binding affinity (Ka = 3.2 +/- 1.7 x 10(6)M-1) of all lignans investigated so far; the reversibility of its binding and a double reciprocal plot suggest a competitive inhibition of the SHBG-DHT interaction. Increasing hydrophobity in the aliphatic part of the lignans (butane-1,4-diol-butanolide-tetrahydrofuran structures) leads to higher binding affinity. In the aromatic part, a 3-methoxy-4-hydroxy substitution pattern is most effective for binding to SHBG.

PMID: 9461660 [PubMed - indexed for MEDLINE]


Planta Med. 1997 Dec;63(6):529-32. Related Articles, Links


Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).

Schottner M, Gansser D, Spiteller G.

Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.

Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).

PMID: 9434605 [PubMed - indexed for MEDLINE]


Many studies suggest that it is " competitive" meaning it competes and beats out shbg. So it is not permanent like a say a suicidal aromatase inhibitor would be when it comes to estrogen. But more like Letro or adex would be. When you stop talking it and once its half life clears the effect stops and SHBG goes back to doing its job.


This is yet another reason why I keep telling people to use Hcgenerate ON CYCLE and forma-stanzol after during pct. WHY..

Well formastan also lowers shbg but a good 34% or more. However it has a "long lasting" effect because it is not competitive in its effects its suicidal.

Formestane as treatment of advanced breast cancer in ... [Tumori. 1994] - PubMed - NCBI
you may read the entire study but Ill skip to the last part. Lower E2=lower SHBG and here is the conclusion to the study

The study showed that formestane induced a long-lasting suppression of E2 levels and a satisfactory overall response. In our opinion, the drug is an effective and well-tolerated approach in the management of advanced breast cancer in elderly patients.

It should also be noted that well using formastan ( main igredent in forma-stanzol) a rise in serum FSH was also observed during the therapy

Now clomid and nolvadex like any serm will cause a RISE in SHBG and a rise in blood level estrogen. This is why using a suicidal aromatase inhibitor and a serm during pct is a must. Now forma-stanzol is a combo of both and than some!!! Add in a great test booster and your pct is complete.

Run your Hcgenerate during cycle , forma-stanzol after. Thank you

 

[needtogetaas]

Ya... I'm that awesome!!! lmao

 

[TheSVPdeal]

Ya... I'm that awesome!!! lmao

Yeah, you are. So would you say that my layman's explaination, more than less, nails it?