depends on the supplement, i can tell you none of the supplements n2bm sells aside from Dspark needs to be taken with food
MOST other things out there you will be fine drinking a glass of water with them so they are water soluble that way
if you find yourself not doing well taking them on an empty stomach then of course have a piece of fruit with them
if you STILL find yourself not doing well taking them then throw them in the trash. a lot of stim based supplements tear up your stomach yet guys continue taking them cause they want to 'shred up'.. in the end they just end up tearing up their stomach and fucking up their heart