GW50 search overload, Simple question.

[GloryDays]

New member of the boards here. I have googled, binged, yahoo'd, and did a EF search and cant seem to find the correct wording to get the answer I want, and its an easy one. I remember reading an earlier article/post on a GW50 log and THOUGHT I read that it does not need to be cycled on and off as it doesn't degrade receptors for it. That is my question, are people cycling their rats on and off GW50 for the unknown health concerns of GW50, or do their rats' receptors become numb to the effects of GW50 after about 8 weeks?

Thank you.

GD

 

[RickRock13]

New member of the boards here. I have googled, binged, yahoo'd, and did a EF search and cant seem to find the correct wording to get the answer I want, and its an easy one. I remember reading an earlier article/post on a GW50 log and THOUGHT I read that it does not need to be cycled on and off as it doesn't degrade receptors for it. That is my question, are people cycling their rats on and off GW50 for the unknown health concerns of GW50, or do their rats' receptors become numb to the effects of GW50 after about 8 weeks?

Thank you.

GD

As with anything, GW needs to be cycled to stay effective. I would recommend an 8 week break after 12 weeks of use to keep it working as it should.

 

[dylangemelli]

You can run it 12-14 weeks then you should take 4 weeks at the minimum off...


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[GloryDays]

Thank you both!

 

[WolfpackAlpha]

New member of the boards here. I have googled, binged, yahoo'd, and did a EF search and cant seem to find the correct wording to get the answer I want, and its an easy one. I remember reading an earlier article/post on a GW50 log and THOUGHT I read that it does not need to be cycled on and off as it doesn't degrade receptors for it. That is my question, are people cycling their rats on and off GW50 for the unknown health concerns of GW50, or do their rats' receptors become numb to the effects of GW50 after about 8 weeks?

Thank you.

GD

As RR and Dylan pointed out, anything that you use - should be cycled. I suggest 4 weeks off every 12 weeks or so, but you can test this subjectively on yourself and see what the best time-off vs. on is for you.

 

[hurricane]

New member of the boards here. I have googled, binged, yahoo'd, and did a EF search and cant seem to find the correct wording to get the answer I want, and its an easy one. I remember reading an earlier article/post on a GW50 log and THOUGHT I read that it does not need to be cycled on and off as it doesn't degrade receptors for it. That is my question, are people cycling their rats on and off GW50 for the unknown health concerns of GW50, or do their rats' receptors become numb to the effects of GW50 after about 8 weeks?

Thank you.

GD

like rick said it losses effectivness.I wouldnt say its exactly 8 weeks but it does over time,use it and when you feel it to start being less effective cease usage

i dont see there being a set amount of weeks each person needs to use, shoot it might not be the same for everyone.There are no real sides or suppression on it.So use it and when it starts to start tailing off stop...VERY SIMPLE!

people tend to over complicate things sometimes for no reason

 

[gymrat827]

take for 12wks, than 5.5wks off. you need to keep receptors fresh so it still has good effects.

 

[FlexManning]

New member of the boards here. I have googled, binged, yahoo'd, and did a EF search and cant seem to find the correct wording to get the answer I want, and its an easy one. I remember reading an earlier article/post on a GW50 log and THOUGHT I read that it does not need to be cycled on and off as it doesn't degrade receptors for it. That is my question, are people cycling their rats on and off GW50 for the unknown health concerns of GW50, or do their rats' receptors become numb to the effects of GW50 after about 8 weeks?

Thank you.

GD

Consensus seems to be that even if staying on it perpetually is better in some way over the course of say a year there are diminishing returns.

 

[Jigga14]

GW has been shown to cause cancer in rats at high doses and long periods of time. I know this doesn't directly relate to humans but it would be advisable to take breaks.

It's unfortunate that the Wikipedia article on gw really hypes this up, I told a friend to check out gw and he went straight to wiki and told me it looks way to dangerous.

 

[sanmarino]

- Ratten und Mäusen wurde GW501516 über 104 Wochen verabreicht, während die längste Dauer der klinischen Studie beim Menschen gerade mal 12 Wochen betrug
- Die Dosierung an Ratten und Mäusen betrugen das 100-1000fache der Einnahmedosis am Menschen.
Zur Erinnerung: die tiefste Dosierung an Ratten betrug 5mg/kg/Tag, die höchste 40mg/kg/Tag. Rechnet man das auf einen 80kg schweren Menschen um, so würde dies über eine Einnahmezeit von 104 Wochen 400mg/Tag respektive 3200mg/Tag betragen. Vergleicht man Mäuse, die trotz höherer Dosierung zu einer statistisch gesehen geringeren Tumorentwicklung neigten, so würde dies auf den selben Menschen umgerechnet 800mg/Tag bis 6400mg/Tag betragen.
- Die Dosis an einem gesunden Menschen betrug 10mg/Tag, während in der Phase IV angeschlagenen Menschen 2.5mg/Tag verabreicht wurde.

Vergleicht man nun die totale verabreichte Dosis und wendet sie auf ein Gewicht von 80kg um, beträgt sie:
- bei der Ratte zwischen 175.2gramm und 2'296gramm (über 104 Wochen)
- bei der Maus zwischen 582.4gramm und 4'659.2gramm (über 104 Wochen)
- beim Menschen zwischen 210mg und 840mg (über 12 Wochen)

- rats and mice received GW over a period of 104 weeks (2 years). The longest period in human trial was 12 weeks.
- The dosage to rats and mice were given 100-1'000times of the human dose.
(for comparison: the lowest dose for rats were 5mg/kg/day and the highest 40mg/kg/day. If a human would take the same dose, then a 80kg-person had to take 400mg/ed (at minimum) and maximum at 3200mg/ed. The mice received a higher dose as the rats and had a less tumor-development in comparison to the rats. If we take the dosage of the mice to humans, so a person had to take between 800mg and 6400mg - PER DAY!
- The dosage of human trials were 10mg/ed, whereas in the trial IV 2.5mg/ed of GW were given to sick people.

As Dylan also said: read the facts and make you an own opinion. He made a lot, to explain the function of GW and to inform about the made studies. Be also critical to the statement of WADA. Here a applicable quote:

There were no side-effects reported in the human studies. But this may be due to short study durations. It may also be due to the small doses used in humans.The side-effects of GW501516 from animal studies were based on large doses of the drug.