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GHRP6 for bulking
- Thread starter John Juan
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John Juan
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Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction.
AuthorsBerlanga J, et al. Show all Journal
Clin Sci (Lond). 2007 Feb;112(4):241-50.
Affiliation
Abstract
Therapies aimed at enhancing cardiomyocyte survival following myocardial injury are urgently required. As GHRP6 [GH (growth hormone)-releasing peptide 6] has been shown to stimulate GH secretion and has beneficial cardiovascular effects, the aim of the present study was to determine whether GHRP6 administration reduces myocardial infarct size following acute coronary occlusion in vivo. Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period. Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline. Hearts were processed, and the area at risk and the infarct size were determined. CK-MB (creatine kinase MB) and CRP (C-reactive protein) levels and pathological Q-wave-affected leads were analysed and compared. Evaluation of the myocardial effect of GHRP6 also included quantitative histopathology, local IGF-I (insulin-growth factor-I) expression and oxidative stress markers. GHRP6 treatment did not have any influence on mortality during surgery associated with rhythm and conductance disturbances during ischaemia. Infarct mass and thickness were reduced by 78% and 50% respectively, by GHRP6 compared with saline (P<0.01). More than 50% of the GHRP6-treated pigs did not exhibit pathogological Q waves in any of the ECG leads. Quantitative histopathology and CK-MB and CRP serum levels confirmed the reduction in GHRP6-mediated necrosis (all P<0.05). Levels of oxidative stress markers suggested that GHRP6 prevented myocardial injury via a decrease in reactive oxygen species and by the preservation of antioxidant defence systems (all P<0.05). Myocardial IGF-I transcription was not amplified by GHRP6 treatment compared with the increase induced by the ischaemic episode in relation to expression in intact hearts (P<0.01). In conclusion, GHRP6 exhibits antioxidant effects which may partially contribute to reduce myocardial ischaemic damage.
AuthorsBerlanga J, et al. Show all Journal
Clin Sci (Lond). 2007 Feb;112(4):241-50.
Affiliation
Abstract
Therapies aimed at enhancing cardiomyocyte survival following myocardial injury are urgently required. As GHRP6 [GH (growth hormone)-releasing peptide 6] has been shown to stimulate GH secretion and has beneficial cardiovascular effects, the aim of the present study was to determine whether GHRP6 administration reduces myocardial infarct size following acute coronary occlusion in vivo. Female Cuban Creole pigs were anaesthetized, monitored and instrumented to ensure a complete sudden left circumflex artery occlusion for 1 h, followed by a 72 h reperfusion/survival period. Animals were screened clinically before surgery and assigned randomly to receive either GHRP6 (400 microg/kg of body weight) or normal saline. Hearts were processed, and the area at risk and the infarct size were determined. CK-MB (creatine kinase MB) and CRP (C-reactive protein) levels and pathological Q-wave-affected leads were analysed and compared. Evaluation of the myocardial effect of GHRP6 also included quantitative histopathology, local IGF-I (insulin-growth factor-I) expression and oxidative stress markers. GHRP6 treatment did not have any influence on mortality during surgery associated with rhythm and conductance disturbances during ischaemia. Infarct mass and thickness were reduced by 78% and 50% respectively, by GHRP6 compared with saline (P<0.01). More than 50% of the GHRP6-treated pigs did not exhibit pathogological Q waves in any of the ECG leads. Quantitative histopathology and CK-MB and CRP serum levels confirmed the reduction in GHRP6-mediated necrosis (all P<0.05). Levels of oxidative stress markers suggested that GHRP6 prevented myocardial injury via a decrease in reactive oxygen species and by the preservation of antioxidant defence systems (all P<0.05). Myocardial IGF-I transcription was not amplified by GHRP6 treatment compared with the increase induced by the ischaemic episode in relation to expression in intact hearts (P<0.01). In conclusion, GHRP6 exhibits antioxidant effects which may partially contribute to reduce myocardial ischaemic damage.
Elvia1023
New member
Great 1st post. How about something about yourself. Look around and you will find a peptide source.
Thanks Elvial023. I'm 40, an ectomorph, 5' 10" and 155 lbs. I was only 140 lbs before TRT last July. I've been lifting on an off for 25 years but never able to maintain an appetite. My diet is near flawless in terms of quality, but suffers from lack of quantity, thus my interest in GHRP-6 and peptides. I see moderators here with coupon codes for peptides, such as you have, but I'm searching for tips on finding an unbiased source. Cheers
Elvia1023
New member
I wouldn't bullshit we really are great... the boss is very honest and a good guy and that's reflects in our products/service. Sponsors pay a large amount to advertise on this forum so they are not small scale operations. Although GHRP-6 is very cheap and easy to manufacture so I imagine many companies will have great product. We advertise on loads of forums so the info is there for you to search (excluding one forum that likes to bullshit about us).
Take 200mcg GHRP-6 on an empty stomach and you will be shocked how hungry it makes you. It really is the perfect peptide for bulking if appetite is an issue. Although the effects on appetite can lower over time so taking little breaks is advised. It's effects on gh release stay the same though so it can be used for long periods with great effect for that.
It's up to you. GHRP-6 is not expensive. If you add 2 vials and use the code BOGO1023 you pay for 1. I appreciate anyone who uses my code but please don't think I am trying to sell you it so I earn money. If you buy those 2 vials using my code I make $2. I would never bullshit anyone for any amount of money but I certainly wouldn't do it for $2
If you decide to try it let me know how it goes.
I'm going to pair GHRP-6 with CJC-1295 w/o DAC since they have different methods of action + an ACEI (huperzine A). Also ordered MK-677 and Ipamorelin for use at later dates. Thanks Elvial023. Ordered some from extremepeptides but I will try your promocode next round.
Last edited:
mfinmonster
New member
Just wanted to add my experience with it for anyone looking for reviews or reports.
My whole life I have struggled to put on weight, and my appetite is no help at all. Normally a female size portion would leave me feeling full and force feeding myself past that point would create a gag reflex when swallowing, after chewing my food for five minutes. I mean, really shit. And at 6'3 skinny doesn't go away quickly.
Enter GHRP-6. One shot of GHRP-6 (2-350 mcg) with 100 mcg of CJC-1295 w/o dac, and I can eat two full sized servings, and head right for some sort of snack after. Twenty minutes later it dawns on me that i've been chewing forever. Jaw begins to get tired before you start to feel full.
If you do eat to satisfaction, you better not have much planned cause you're gonna wanna nap or lay down cause your gut is PACKED. I mean bulging from beneath my rib cage.
I also stack it with Synthetek's Appetite Stimulator (High Dose Cyano and Hydroxycobalamin b-12)
I still have trouble putting the pounds on due to my furnace for a metabolism, but it helps better than anything i've ever tried.
My whole life I have struggled to put on weight, and my appetite is no help at all. Normally a female size portion would leave me feeling full and force feeding myself past that point would create a gag reflex when swallowing, after chewing my food for five minutes. I mean, really shit. And at 6'3 skinny doesn't go away quickly.
Enter GHRP-6. One shot of GHRP-6 (2-350 mcg) with 100 mcg of CJC-1295 w/o dac, and I can eat two full sized servings, and head right for some sort of snack after. Twenty minutes later it dawns on me that i've been chewing forever. Jaw begins to get tired before you start to feel full.
If you do eat to satisfaction, you better not have much planned cause you're gonna wanna nap or lay down cause your gut is PACKED. I mean bulging from beneath my rib cage.
I also stack it with Synthetek's Appetite Stimulator (High Dose Cyano and Hydroxycobalamin b-12)
I still have trouble putting the pounds on due to my furnace for a metabolism, but it helps better than anything i've ever tried.
I dated a fat girl once who seemed like she took 500mcg ghrp6 before each meal. That girl ate as much as I did after I came off a 9 month precontest diet. She sure could cook though. I miss that a lot.
Holy fucking shit. It's 2am and I just pissed myself laughing. #reasonsiloveEF
I should add make sure you have no family sized tubs of ice cream as you will eat it all. For me family sized blocks of cheese will also be devoured. As will about 10 other things. Make sure you have lots of good nutritious food ready to be utilized
He said a block of cheese! 2nd time pissing myself laughing.
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