GHB Alternative - Tranquili-G?!

[rogerwilcox]

I'm excited about the potential here, but want to know if any of the bros and sisters here have tried it.

It's seems like the main complaint I hear against it is that it doesn't get you "high" like GHB.

My only interest in GHB and it's analogues is for health.

If Tranquili-G increases GH levels and helps you sleep, I can live without the high (hey, if you wanna get high, go smoke some herb, I say).

Does anyone have any experience with Tranquili-G in this way? Does it truly increase GH levels to the same extent as GHB? As for the sleep, I hear it helps you relax, but doesn't knock you out the way G does - but lasts longer so helps you sleep for longer periods of time and not the short 3 hours of G sleep.

Does it also help you store up dopamine in the brain so you're wide awake when you wake up after taking the stuff?

Anyway, please don't respond with "well, I heard so and so say". Please post your personal experiences with or scientific discussions of the uses of tranquili-G. Or links to more info.

The marketing for it looks good, of course, but so does the marketing for a lot of snake oil.

Let's get some facts. If it is what I think, I'm stoked.

Peace,

Roger Jr.

 

[Ryvor]

I've read it's not that good.
Try it and let us know.

 

[-{ GODZILLABOL }-]

Bump!

 

[diamonddiceclay]

according to duchaine, "ghb can probably raise gh in individuals who can still secrete GH w/ stimulus,however, this ability declines radically with age"-he also said that ghb raises CORTISOL

 

[rogerwilcox]

bump for more responses - this could be important - in that it will help people find a potential great new supplement or prevent them from getting ripped off by taking junk - anyone tried it?

 

[Jacob Creutzfeldt]

Ask Par Deus

I think Par Deus, who posts on the supplement board, runs Avant Labs (the distributor of Tranquil-G). I'm sure he would have more info.

 

[rogerwilcox]

Jacob - thanks, bro.

I sent a private message to par deus. Hope he checks that. Anyone else here know how to get in touch with him, please pass the word on that his response is requested here. I'm sure he'll have some good stuff to say.

 

[rogerwilcox]

Barring any response from Par Deus yet (I'm sure he's just busy), I found the following posted on his site:

http://www.avantlabs.com/cgi-sz/webcwrap/szw/ai_rebuttal.htm?sid=4yWNn20HE4uY3HL-23101024839.98

Looks like Anabolic Insider wrote a negative article about Tranquili-G and Par Deus is defending himself (quite eloqently, I should add) here.

Can anyone get Par Deus in here to give us some info? Do they have any scientfic info about the effectiveness of this new drug on sleep, GH levels, and dopamine?

Anyone have any facts or any experiences to share?

Roger Jr.

 

[Par Deus]

There is not a great deal of direct data on the direct effects of 4-pentanolide, the active ingredient in Tranquili-G, so we can only speculate -- however, there is good data for speculation, so it is not just a W.A.G.

The physiological effects produced by GHB that we cannot directly feel (i.e. reductions in anxiety should be obvious) such as increases in growth hormone are well established with oral usage of moderate dosing. Growth Hormone increases of 300% are seen with an oral dose of 1.5g.

GHB works, initially via binding with specific GHB receptors (its actions are then modulated by various neurotransmitter systems (GABA, dopamine, opioid, etc.). The conversion product of 4-pentanolide, GHV, has been found to bind to the GHB receptor (with greater affinity than GHB), so it would be expected to produce the same type of physiological effects.

On paper, they would be expected to be stronger, but this has not been the case, likely due to a transport issue, or weak post-receptor signalling.

So, the question is -- how does the signal actually produced compare to 1.5g of GHB -- which was adequate to produce a 300% increase in growth hormone. For this, we can compare the subjective psychoactive effects, since, as mentioned, it works through specific receptors, thus different binding to another receptor system can be ruled out, as can modulation by a metabolite, because there are none with significant activity.

Comparing the subjective effects -- the dose of 4-pentanolide in Tranquili-G feels like about 1-1.5g of GHB -- but, it lasts longer.

So, the best guess, given what we know, is that it would have a similar effect on GH, pehaps slightly less, but that it would last longer.

Its effects on REM sleep, dopamine, and everything else, would also be quite similar in type, with a lower magnitude, but of a longer duration.

 

[rogerwilcox]

Thanks for the helpful reply, Par.

Couple quick questions:

a. If one increases the dose, can you match the other effects of GHB? (inebriation, etc.) Frankly, if it doesn't totally knock you out (and just makes you really sleepy), that's a plus for me as it will stay legal longer.

b. Does it make you tired enough to really help sleep? If Melatonin was a 1 (little tired) and GHB was a 10 (knocking you on your ass), where would tranquili-g be on that scale?

c. Do you plan to conduct any tests measuring the GH, dopamine, and sleep effects of tranquili-g?

As you know, your substance has huge potential. If you could prove it's efficacy you'll be a very rich man. Most of the people on the board here will be very interested - the implications for bodybuilding are huge.

Peace,

Roger