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I've been considering using an Ipam/Mod GRF combo for a while now but I've been dragging my heels for a few reasons. First, I haven't seen any studies using these peptides on humans. Second, I think injecting myself once or twice a day for the very moderate improvements these drugs promise would get old quickly. This has led me to do a bit of searching to see if there was anything else available that had been tested on humans and did not have to be injected. I came across GABA. Here is the study:
Growth hormone isoform responses to GABA ingestion at rest and after exercise.
Powers ME, Yarrow JF, McCoy SC, Borst SE.
Source
Division of Athletic Training, Shenendoah University, Winchester, VA 22601, USA.
Abstract
Oral administration of the amino acid/inhibitory neurotransmitter gamma aminobutyric acid (GABA) reportedly elevates resting serum growth hormone (GH) concentrations.
PURPOSE:
To test the hypothesis that GABA ingestion stimulates immunoreactive GH (irGH) and immunofunctional GH (ifGH) release at rest and that GABA augments the resistance exercise-induced irGH/ifGH responses.
METHODS:
Eleven resistance-trained men (18-30 yr) participated in this randomized, double-blind, placebo-controlled, crossover study. During each experimental bout, participants ingested either 3 g of GABA or sucrose placebo (P), followed either by resting or resistance exercise sessions. Fasting venous blood samples were acquired immediately before and at 15, 30, 45, 60, 75, and 90 min after GABA or P ingestion and were assayed for irGH and ifGH.
RESULTS:
At rest, GABA ingestion elevated both irGH and ifGH compared with placebo. Specifically, peak concentrations of both hormones were elevated by about 400%, and the area under the curve (AUC) was elevated by about 375% (P < 0.05). Resistance exercise (EX-P) elevated time-point (15-60 min) irGH and ifGH concentrations compared with rest (P < 0.05). The combination of GABA and resistance exercise (EX-GABA) also elevated the peak, AUC, and the 15- to 60-min time-point irGH and ifGH responses compared with resting conditions (P < 0.05). Additionally, 200% greater irGH (P < 0.01) and 175% greater ifGH (P < 0.05) concentrations were observed in the EX-GABA than in the EX-P condition, 30 min after ingestion. GABA ingestion did not alter the irGH to ifGH ratio, and, under all conditions, ifGH represented approximately 50% of irGH.
CONCLUSIONS:
Our data indicate that ingested GABA elevates resting and postexercise irGH and ifGH concentrations. The extent to which irGH/ifGH secretion contributes to skeletal muscle hypertrophy is unknown, although augmenting the postexercise irGH/ifGH response may improve resistance training-induced muscular adaptations.
---I understand that for every positive study available you can usually find two that completely contradict it, but I still found this report to be encouraging. I'm looking for comments especially from those who have used GABA as well as GHRPs/GNRHs, or at least from those who are somewhat versed in this material. I'm curious if there is any legitimate comparison here. Common sense tells me no because why would people use products that are borderline legal and require frequent injection over GABA, which is both approved for human consumption and orally available, if it is as effective as this study seems to demonstrate. Curious to hear what people have to say about this.
Growth hormone isoform responses to GABA ingestion at rest and after exercise.
Powers ME, Yarrow JF, McCoy SC, Borst SE.
Source
Division of Athletic Training, Shenendoah University, Winchester, VA 22601, USA.
Abstract
Oral administration of the amino acid/inhibitory neurotransmitter gamma aminobutyric acid (GABA) reportedly elevates resting serum growth hormone (GH) concentrations.
PURPOSE:
To test the hypothesis that GABA ingestion stimulates immunoreactive GH (irGH) and immunofunctional GH (ifGH) release at rest and that GABA augments the resistance exercise-induced irGH/ifGH responses.
METHODS:
Eleven resistance-trained men (18-30 yr) participated in this randomized, double-blind, placebo-controlled, crossover study. During each experimental bout, participants ingested either 3 g of GABA or sucrose placebo (P), followed either by resting or resistance exercise sessions. Fasting venous blood samples were acquired immediately before and at 15, 30, 45, 60, 75, and 90 min after GABA or P ingestion and were assayed for irGH and ifGH.
RESULTS:
At rest, GABA ingestion elevated both irGH and ifGH compared with placebo. Specifically, peak concentrations of both hormones were elevated by about 400%, and the area under the curve (AUC) was elevated by about 375% (P < 0.05). Resistance exercise (EX-P) elevated time-point (15-60 min) irGH and ifGH concentrations compared with rest (P < 0.05). The combination of GABA and resistance exercise (EX-GABA) also elevated the peak, AUC, and the 15- to 60-min time-point irGH and ifGH responses compared with resting conditions (P < 0.05). Additionally, 200% greater irGH (P < 0.01) and 175% greater ifGH (P < 0.05) concentrations were observed in the EX-GABA than in the EX-P condition, 30 min after ingestion. GABA ingestion did not alter the irGH to ifGH ratio, and, under all conditions, ifGH represented approximately 50% of irGH.
CONCLUSIONS:
Our data indicate that ingested GABA elevates resting and postexercise irGH and ifGH concentrations. The extent to which irGH/ifGH secretion contributes to skeletal muscle hypertrophy is unknown, although augmenting the postexercise irGH/ifGH response may improve resistance training-induced muscular adaptations.
---I understand that for every positive study available you can usually find two that completely contradict it, but I still found this report to be encouraging. I'm looking for comments especially from those who have used GABA as well as GHRPs/GNRHs, or at least from those who are somewhat versed in this material. I'm curious if there is any legitimate comparison here. Common sense tells me no because why would people use products that are borderline legal and require frequent injection over GABA, which is both approved for human consumption and orally available, if it is as effective as this study seems to demonstrate. Curious to hear what people have to say about this.
