When you start to age ,facial muscles go south ,get wrinklesand crowsfeet in the eyes,and your jaw seems to jiggle alot more then it used to,then you should have been on HGH a few years ago. I'm 54 and I don't have any of those signs and I think that HGH is a miracle for me. I am on HGH because of endocrine problems and I am on test enthanate too. I wake up everyday refreshed from a good nights sleep and am not afraid to look in the mirror either to see which way my face has gone. My skin is definately tighter,thicker and younger looking. My attitude is much better since I started HGH . I heal from cuts,knicks,scapes very easily. I would say that my heart,lungs,and intenal organs have'nt suffered from HGH at all. Younger people such as 20 or 30 are excited at trying HGH only to be discouraged later. I tell people wait to try HGH till at least 30 and then I feel like I've done my part .