Exemestane crystallization

[ganoman]

Hows it going

So i bought some exemestane a few months ago because of a crazy deal, and i kept it in the fridge and it crystallized

did some research, then heated it in a microwave for less than 10 seconds, shook it up, and it dissolved slightly, there are tiny particles in the solution.

Should i just store at room temp? Whats the shelf life on this stuff? Was told it was over a year.

Thanks mates

 

[1ugafreak]

Exemestane is only soluble to 15mg/ml in ethanol at 77F so the crytals are the chem making it difficult to dose accurately if crytals are present. Using DMSO you can get 54mg/ml, at 77F kinda awful though. There is a formulation to keep it in solution but doubt they went to the trouble. Few do just heat bottle in bit of water in a pan. Most will dissolve then dosing is more accurate.
As for storage mfr says 100% good after 6 months at -80C in DMSO.lol
If it works at a year that's fine but to what degree it has degraded, have no clue. It's powerful even 10+% loss no worries.


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[shaved_ape]

Exemestane is only soluble to 15mg/ml in ethanol at 77F so the crytals are the chem making it difficult to dose accurately if crytals are present. Using DMSO you can get 54mg/ml, at 77F kinda awful though. There is a formulation to keep it in solution but doubt they went to the trouble. Few do just heat bottle in bit of water in a pan. Most will dissolve then dosing is more accurate.
As for storage mfr says 100% good after 6 months at -80C in DMSO.lol
If it works at a year that's fine but to what degree it has degraded, have no clue. It's powerful even 10+% loss no worries.


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I hold mine in 190 grain alcohol at 30mg/ml. 50mg crashed, once exposed to normal atmosphere.

If it crashes heat in a water bath. And recap.


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[buddhabuilder]

Only heat it as much as required to dissolve crystals and then keep at room temp.

 

[nwamuscle]

I had a similar issue before I started capping them. I would just add some everclear or 190 grain alcohol, heat it up, and wait to see if it holds in solution.

 

[1ugafreak]

Straight from chem mfr listing, books aren't always correct but I'm
Surprised. I'd kinda doubt you have pure exemestane??

Aromatase Inhibitors > Exemestane

Product Information
Molecular Weight (MW): 296.4
Formula:
C20H24O2
CAS No.:107868-30-4

Solubility (25°C):
DMSO 54 mg/mL
Water <1 mg/mL
Ethanol 15 mg/mL

Biological Activity
Description:
Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

In vitro:
Exemestane competitively inhibits and time-dependently inactivates of human placental aromatase with Ki of 4.3 nM. Exemestane displaces [3H]DHT from rat prostate androgen receptor with IC50 of 0.9 μM. [1] Exemestane (1 μM) increases alkaline phosphatase activity in hFOB and Saos-2 cells and induces the expression of MYBL2, OSTM1, HOXD11, ADCYAP1R1, and glypican 2 in hFOB cells. [2] Exemestane causes aromatase degradation in a dose-responsive manner in MCF-7aro cells. [3]

In vivo:
Exemestane increases lumbar spine BMD by 14.0% in OVX rats at dose of 100 mg/kg. Exemestane (100 mg/kg) and 17-hydroexemestane (20 mg/kg) significantly reduces an ovariectomy-induced increase in serum pyridinoline and serum osteocalcin in rats and causes significant reductions of serum cholesterol and low-density lipoprotein cholesterol inOVX rats. [4] Exemestane (20 mg/kg/day s.c.) induces 26% complete (CR) and 18% partial (PR) tumor regressions in rats with 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumors. [5]
References
ht out of chemical data sheet


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[forexconsultant]

Same thing here,but didnt refrigerate.kept at room temp-ooened bottle for first time and fairly heavily crystalized.had to hold dosing tube under HOT water for awhile because crystals had clogged it shut.sat bottle in hot bath for about 10 minutes and it helped somewhat. Stuff is still real cloudy, and can see it separate after a few minutes. What to do?