Wilson6, is that tranny's WITH ovaries or without? I assume it's with. Either way, your advice to have estrogens measured a few days her T shot and see where it's at. Might pay to try this after withdrawing her from the supplemental estrogen. I don't know her age or full medical history, but the majority of women function just fine with one ovary. I presume the Doc has run some blood tests to check her estrogen levels before giving her the Premarin?? As for test dose, that's for her to decide. If she just wants 'normal' libido and health, then she could lower the does A LOT. If she wants to be a competitive bodybuilder, then she's on the right track, but may have to sacrifice some femininity to get there and stay there.