Ester Half Life Clarity

[beastfit]

For the life of me, I cannot wrap my head around the half-life of testosterone and I'm hoping somebody here can explain how long the testosterone is active in my system and providing the desire anabolic effect and not just hanging out in my fat or floating around in my blood. Please forgive me as my medical and chemistry background is non-existent and I'm doing my best to determine how our bodies utilize aas.

Based on my research, Testosterone Suspension has no ester carbons starts to bind to your receptors immediately and has virtually no half-life.

Testosterone Propinate is a 3 carbon ester of which our body's enzymes "cleave" off the molecules to make a testosterone compound that dissolves in our blood stream and binds to the receptors. The half-life of this compound is 2 days.

How is the half-life 2 days? I thought once the esters were cleaved off, the testosterone was immediately available. Meaning, after the ester carbons are removed, don't we basically have the same thing administered testosterone suspension? Does it take 2 days for all of the testosterone molecules to have it's 3 esters cleaved off? Are the molecule's ester carbons cleaved off at random intervals between 0 - 4 days therefore making the half-life really an average 2 days?

Thanks in advance for any insight provided.

Happy New Year!!!

 

[stevesmi]

because prop and suspension are different.

 

[beastfit]

I agree, they're different only because of the ester, correct? What I'm wondering his exactly how the half-life is calculated in regard to the esters. I used prop for an example, however, the question could apply to cypionate.

Using prop as an example, what I'm wondering is:

Does it take 2 days for all of the testosterone molecules to have it's 3 esters cleaved off?
How is the half-life determined, are the molecule's ester carbons cleaved off at random intervals between 0 - 4 days therefore making the half-life really an average 2 days?

 

[jcnuts]

Compound X is 50mg/ml and it's half life is 3 days. You inject 1ml of X which is 50mg. On day 3 there is still 25mg of the compound still inside you working. On day 6 there is 12.5mg, day 9 is 6.25, and so on and so forth. As far as determining how long an esters half life would be like Cypionate or Propionate that was determined through research, trials, and bloodwork when they were invented. I think the answer you're looking for is more on the chemistry side and how long the body takes to break down certain ester chains then you need to Google steroid chemistry and word the search appropriately to what you want to know.

~ JohnyCoolNuts ~

 

[MaxxReps]

The thing is, the ester determines how water soluble the compound is. The shorter the ester, the more water soluble. So the compound (test + ester) slowly enters the bloodstream at a rate that is determined by ester length. Once in the bloodstream esterase enzymes strip the enzyme from the compound and the hormone is then bioavailable.

At least thats the way I understand it.

 

[stevesmi]

I agree, they're different only because of the ester, correct? What I'm wondering his exactly how the half-life is calculated in regard to the esters. I used prop for an example, however, the question could apply to cypionate.

Using prop as an example, what I'm wondering is:

Does it take 2 days for all of the testosterone molecules to have it's 3 esters cleaved off?
How is the half-life determined, are the molecule's ester carbons cleaved off at random intervals between 0 - 4 days therefore making the half-life really an average 2 days?

why are you wondering just curious?

suspension hurts like hell and unless you are a tested athlete I see no advantage to mess with it. stick with E which is smooth

you can easily answer your own questions by reading studies online and the literature on each ester. I will tell you this.. once prop for example builds up in the system and you stop injecting its going to take more than just a couple days to clear out. even a small fraction of remaining notes leftover WILL still suppress your HPTA. this is why tapering down is pointless, the compound will taper down on its own and no matter what you do it takes a certain amount of time to clear out ..

just imagine a hole and a bunch of rats in a shed. then light the shed on fire and the rats will scurry through the hole to get out. no matter how hard they try its still going to take time for each one to get through the hole

 

[hurricane]

For the life of me, I cannot wrap my head around the half-life of testosterone and I'm hoping somebody here can explain how long the testosterone is active in my system and providing the desire anabolic effect and not just hanging out in my fat or floating around in my blood. Please forgive me as my medical and chemistry background is non-existent and I'm doing my best to determine how our bodies utilize aas.

Based on my research, Testosterone Suspension has no ester carbons starts to bind to your receptors immediately and has virtually no half-life.

Testosterone Propinate is a 3 carbon ester of which our body's enzymes "cleave" off the molecules to make a testosterone compound that dissolves in our blood stream and binds to the receptors. The half-life of this compound is 2 days.

How is the half-life 2 days? I thought once the esters were cleaved off, the testosterone was immediately available. Meaning, after the ester carbons are removed, don't we basically have the same thing administered testosterone suspension? Does it take 2 days for all of the testosterone molecules to have it's 3 esters cleaved off? Are the molecule's ester carbons cleaved off at random intervals between 0 - 4 days therefore making the half-life really an average 2 days?

Thanks in advance for any insight provided.

Happy New Year!!!

suspension is pure testosterone, it is out of your system in a couple of hours. Propionate is a short ester, but long enough to slow the release so that it lasts for ~2 days.

 

[beastfit]

Compound X is 50mg/ml and it's half life is 3 days. You inject 1ml of X which is 50mg. On day 3 there is still 25mg of the compound still inside you working. On day 6 there is 12.5mg, day 9 is 6.25, and so on and so forth. As far as determining how long an esters half life would be like Cypionate or Propionate that was determined through research, trials, and bloodwork when they were invented.

Thanks for your explanation. For the compound to be soluble in your blood, the ester carbons need to be cleaved off, do I have that part correct at least? So basically, the 3 ester carbons are being cleaved off at random intervals, which in your example of Propionate 50mg/ml, on day 3, 25mg of the 50mg (minus ester weight) would have had the 3 carbons cleaved off?

why are you wondering just curious?

Mostly, yes, I am curious. I'm at the beginning phases of my first cycle and I have a good handle on what the compounds are doing in my body, now I'm trying to figure out the how.

just imagine a hole and a bunch of rats in a shed. then light the shed on fire and the rats will scurry through the hole to get out. no matter how hard they try its still going to take time for each one to get through the hole

I like the idea of the visual, but the one I'm getting is the rats are too large to fit through he hole and are only able to go through the hole once they lose size (or ester carbons). In relation to this visual, I'm wondering of the rats lose size (half-life) and random intervals and go through he hole gradually?

I think the answer you're looking for is more on the chemistry side and how long the body takes to break down certain ester chains then you need to Google steroid chemistry and word the search appropriately to what you want to know.

you can easily answer your own questions by reading studies online and the literature on each ester.

I have spent a good amount of time researching testonstrone and esters, what I'm missing is the actual body chemistry. I've bumped in to few articles related to this subject and my eyes start glazing over, I guess I'm at the early phases of this research and looking for a layman's explanation.

 

[stevesmi]

^^^ the number of rats represents TIME you have been on.. the longer you are on the more rats breed in the shed as some rats escape through the hole.. once you stop injecting all breeding in the shed comes to a halt and the rats continue to flee the shed at the same speed but since there are no rats breeding anymore they will slowly taper away till there are no more rats left in the shed and your body can start recovering ..

 

[ForearmzBrah1]

Ok if u google testosterone in images u will see a tree thing with shapes n shit thats a testosterone molecule. Connected on that to make an ester is your carbon atoms. Pure test is water soluable just like your blood but as you add carbon atoms the test becomes less water soluable and more like an oil making it harder for your blood to absorb it as it has to wait for the carbon chains in the testosterone molecule to break down. An exmple is if you put water and oil in a bottle they wont mix. Ok with prop there is 3 carbon atoms and scientific study shows it takws 2 days for half the testosterone molecules to be absorbed into the body.
Lets say 1ml of prop has about 1million testosterone molecules in it. Every second or whatever "5" molecules are absorbed into the blood and give u that sweet strength
But 1ml of deca with 1 million testosterone molecules has more carbon atoms and is therefore less water soluable so every secod only "1" molecule is absorbed. Therefore for the prop to reach its halflife of 2 days, 500,000 test moelcules are absorbed but in deca maybe only 50,000 molecules are absorbed in that time.
These arent real numbers but yea thats kinda all u need to know on a basic scientific level