Roy said:
. And yes it does change the way we are able to create ATP, by basically making it so that the body shuts down the process of chemiosmosis. That in turn consumes all fuel molecules, including stored fuel. So you end up getting onlt 4 ATP per glucose molecule in a given cell, explaining your absolutely exhausted state. Normally you get around 34-38 ATP per cell. And all this burnt energy will be lost as heat, explaining the tremendous sweating that occurs
Roy
Chemical Wizard??? lol... Have a seat on the bus...
Here's part of a thread I started.. I urge you to check out the rest of it.... If you cannot access it, buy a platinum membership.
http://boards.elitefitness.com/forum/showthread.php?s=&threadid=71780&highlight=DNP
Hopefully this will clear up some misinformatio on DNP.
Even on high dose of DNP, the majority of ATP is STILL made via oxidative phosphorilation. A lot of people think that DNP completely eliminates oxidative phosphorilation and that cellular ATP synthesis relies exclusively on substrate level phosphorilation. Actually though, DNP just makes oxidative phosphorilation a LITTLE less efficient. ATP levels in cells really don't change that much. Previously in many biochemistry books, ATP is listed as an important metabolic regulator. In reality, ATP isn't an important regulator since the energy charge of a cell doesn't change all that much. What IS an important metabolic regulator is AMP. And what DNP does do is keep AMP levels high enough to keep green lights going on all glycolytic and TCA enzymes.
Incedentally, the high AMP levels inhibit glycogen synthesis in liver as well as muscle. This means that glucagon and epinephrine dominate over insulin. While this is great for fat loss, it isn't so great for muscle preservation since glucagon also stimulates the liver to make glucose out of amino acids (gluconeogenesis) derived from muscle tissue. Hence DNP being "anti-proteolytic" isn't a great assumption.
DNP does not directly stimulate muscle breakdown however the effects that it causes in the body certainly promote muscle breakdown. I might also add that the causes of death from DNP is not a result of low ATP but, rather, from the extreme heat that DNP causes.
As far as limiting factors with DNP and fat loss, well, there aren't any. In a test tube with mitochondria, oxygen becomes the limiting factor. However this is not the case in vivo since the levels of DNP used for the in vitro tests are far beyond what would be lethal in a human body.
Andy