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Does anybody know if there is a difference between R-ala and just plain ala? Do they both do the same things or not? Thanks
Difference between R-ala and ala
- Thread starter Denilson35
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sawastea
Well-known member
ALA vs. R+
Standard ALA or racemic is a mixture of the r-ala and s-ala isomer's. s-ala seems to have detrimental side effects while r-ala has all the benefits. racemic ALA works because the r-ala's benefits are more pronounced than s-ala's negative effects. The most important thing to note in regards to post workout nutrition is racemic ALA should not be taken post workout as it seems to inhibit glycogen synthesis. This is due to the s-ala isomer, r-ala lacks this quality and should be taken post workout to maximize non-insulin dependent glucose transport.
In terms of overall health high doses of racemic ALA may not be advisable as rats given s-ala had shortened life spans compared to control group while rats given r-ala had extened life spans. racemic ALA has shown to be a potent antioxident and helps improve overall health in studies using lower doses (around 600mg/day). Which indicated the body can handle some portion of s-ala because the r-ala benefits are more potent. However if their is a shift in benefit vs detriment curve at higher doses of racemic ALA is undermined.
So what all this means is r-ala carries all the benefits of racemic ALA with none of the negative effects. Also the absence of the s-ala isomer enhances the overall effect of r-ala because the r-ala form does not have to counterbalance the negative effects of the s-ala form.
Standard ALA or racemic is a mixture of the r-ala and s-ala isomer's. s-ala seems to have detrimental side effects while r-ala has all the benefits. racemic ALA works because the r-ala's benefits are more pronounced than s-ala's negative effects. The most important thing to note in regards to post workout nutrition is racemic ALA should not be taken post workout as it seems to inhibit glycogen synthesis. This is due to the s-ala isomer, r-ala lacks this quality and should be taken post workout to maximize non-insulin dependent glucose transport.
In terms of overall health high doses of racemic ALA may not be advisable as rats given s-ala had shortened life spans compared to control group while rats given r-ala had extened life spans. racemic ALA has shown to be a potent antioxident and helps improve overall health in studies using lower doses (around 600mg/day). Which indicated the body can handle some portion of s-ala because the r-ala benefits are more potent. However if their is a shift in benefit vs detriment curve at higher doses of racemic ALA is undermined.
So what all this means is r-ala carries all the benefits of racemic ALA with none of the negative effects. Also the absence of the s-ala isomer enhances the overall effect of r-ala because the r-ala form does not have to counterbalance the negative effects of the s-ala form.
Stryc-9
New member
"Plain" ala (otherwise known as racemic ala) is a 50/50 split of r-ala and s-ala (the two known isomers of lipoic acid). The consensus these days is that r-ala is more potent with respect to insulin sensitivity (i.e., r-ala lowers plasma insulin levels wheras the s-variant does not). So the plain variety ala is really just a watered down version of r-ala (because s-ala is considered more or less useless in terms of promoting lipolysis).
Denilson35
New member
Thanks guys
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