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Needtobuildmuscle.com takes your training to the next level with our all new designer supplements stacks. This month needtobuildmuscle.com explains everything and makes it easer then ever to Stack our cutting edge products. Needtobuildmuscle.com believes in educating our customers in the safe proper use of all our products. Not only that but also educating our customers on how and why they work.
1. What are Designer supplements?
Designer supplements are used by athletes looking to increase size, strength, endurance, reduce recovery time or add lean body mass. They are most often used for increasing muscle mass or reducing bodyfat levels. Life extension groups are also increasingly using designer supplements as a means of hormone replacement therapy, as an alternative to prescription drug use. A trustworthy Company Will clearly indicate what is in there products on there label and there web site. It may seem like a lot of mobo jumbo to you at first when you see compounds like
19-Norandrosta 4,9 diene- 3,17 dione
2a, 17a-dimethyl-5a-androst-3-one-17b-ol
13 ethyl 3 methoxy
17a-methyl-etioallocholan-2-ene 17b-ol
4-chloro-17a-methyl-androst-1,4- diene-3-17b-dio
But if you take this information and search the internet or bodybuilding forums like (elitefitness.com) You will quickly start to understand what each compound is and how it works.
2 .Do they have side effects?
Yes. Designer supplements can have the same side effects as any anabolic compound, and are dependent upon the user as to which side effects one might experience. Some side effects are acne, hair loss, breast tissue enlargement, and prostate swelling. The potential for these side effects does exist, but it can be reduced if one uses proper precautionary measures (Which we explain for you). Generally, if a person is genetically predisposed to a side effect it will occur (i.e.: if someone has a history of male pattern baldness in the family, it could be assumed that this could be a side effect experienced if certain Designer hormones are used). Needtobuildmuscle.com carries the most cutting edge support sups that are commonly excepted to help reduce side effects from designer Hormone cycles. It is recommended that you always consult your physician before using Designer supplements
5. How do Designer supplements work?
1. Each Designer supplement works in different ways but the end results of each Designer supplement process is it attaches to an androgen receptor in the cells of your body. This in turn increases nitrogen retention and protein synthesis, meaning that your body is in a constant anabolic state (assuming you are continuously supplying your body with the supplement).
Here is a list of this months needtobuildmuscle.com’s featured Designer supplements with full detailed descriptions of there use and effectiveness.
Katanadrol
Like the mighty katana Katanadrol is the king of cutting. With the power of Katanadrol you can be like the katana blade.Thin yet deadly powerful. Sleek yet unbreakable as carbon steel.
Katanadrol active ingredients
19-Norandrosta 4,9 diene- 3,17 dione 40mg per cap 4-chloro-17a-methyl-androst-1,4- diene-3-17b-dio 10mg per cap 90 capsules per bottle
Using Katanadrol and expected results.
Dosage 2-3 cap every day Spread out evenly
Katanadrol is a great designer supplement for people looking to drop body fat well still maintaining muscle size and strength. People competing in weight classed events will find that Katanadrol can give them the extra strength and speed they need with out adding to much bulk. All gains with Katanadrol are lean and hard.
Katanadrol can be added to almost any Designer supplement stack adding muscle strength and fat lose properties to the stack.
19-Tren-Tfo
19 tren Tfo Is the ultimate stacking Designer supplements. It is non methylated therefore it adds no extra stress to the liver or the body. It can not convert to estrogen
Or dht so it will not cause any bloat or problems with lipid profiles. Raising hormone
It will add lean muscle and strength on its one but it’s the most synergistic stacking compound to date.
19-tren-tfo
Using Tren-tfo and expected results.
Dosage 2-3 cap every day Spread out evenly
Tfo will give good strength and size gains for any users on its own. Designer supplement beginners have reported great gains using Tfo on its own and advanced users report fairly good gains as well.
The real power of Tren-tfo lies in its synergistic stacking power. When added to any stack it magnifies gains. From adding more bulk to a bulking stack to aiding in fat burning in a cutting stack. There is no question Tfo is the king of stacking.
Deiselbolan
Deiselbolan is a super charged muscle building combo designed to help you gain muscle while staying lean. Work out longer lift stronger and break through plateaus with Deiselbolan. It helps prevent muscle brake down after work outs. Deiselbolan has Massive nutrition retention power. The more you feed your muscles well on dieselbolan the more they will grow. Deiselbolan packs on muscle mass. Bulking is the name of the gain. With the synergistic combo of compounds in Deiselbolan it is not your typical sloppy bulk. Gains are big yet clean. Bloat is kept to a minimum if any at all.
Deiselbolan active ingredients
Ingredients per cap.
13 ethyl 3 methoxy, 25mg
17a-methyl-etioallocholan-2-ene 17b-ol 15mg
90ct bottle
Using deiselbolan and expected results.
Dosage 2-3 cap every day Spread out evenly.
Deiselbolan builds mass plan and simple. Threw nutrition retention, Anabolic Ar activity, Fast muscle recovery, And enhanced muscle endurance Deiselbolan packs on the mass like no other.
Deiselbolan Is the perfect base compound for any cycle. Use it in as a stand alone bulking products. A base compound for a bulking cycle, or As the kick start to a lean mass cycle as well.
Beastdrol
is a powerful product that commands respect. Strength gains with beastdrol are truly Amazing, and all the gains in size are lean and hard. Many people report a good amount of size with an incredible amount of strength as well. Every once of muscle gained is lean and rock hard.
Beastdrol active ingredients
2a, 17a-dimethyl-5a-androst-3-one-17b-ol 10mg per pill
L-Carnintine L-Tartrate 500mgs per pill
Using Beastdrol and expected results.
Dosage 2-3 cap every day Spread out evenly
All the gains from beastdrol are rock solid and hard. Good muscle size has been reported using Beastdrol and Fierce strength gains are common. Beastdrol is a great stand alone Designer supplement. When stacking bestdrol in cycles the possibility are endless. Use it to harden up gains at the end of a bulk. Combine it with other compounds to gain massive amounts of muscle and strength, and much more.
Designer supplement cycle Enhancers, support susp, and pct products.
What are cycle enhancers, support supplements, and pct products?
Anything that adds to the the cycles gains, Reduces it’s sides, Enhances its effects or the users overall feeling, health, or state of mind. Also any product that helps the user fully recover from the cycle mentally, hormonally, and Physically. Needtobuildmuscle.com offers a number of these products for out users. And we are always on the cutting edge searching for new and exciting products. Here is a list of Needtobuildmuscle.coms cycle enhancers , support supplements , and pct products.
Dermacrine
Dermacrine helps support a raging sex drive, aggressive mental focus, and an intense appetite. It helps prevent The lethargic feeling that is some times common with Designer supplements. Many don’t realize that there are over a dozen different natural hormones which act like testosterone to positively influence muscle gains, strength and libido.(1) Dermacrine delivers a hefty dose of DHEA and Pregenenolone, bio-identical precursors for the essential male hormones. More specifically, DHEA readily converts to the hormones androstenedione, androstenediol, and androsterone.(2-8) These are known as anabolic/androgenic hormones that are responsible for “all that is man” including libido, muscular development, aggression and recovery. Therefore, it is important to keep these hormones elevated with Dermacrine, especially during a steroid cycle when the production of these natural hormones are shut down!
Consider this -- DHEA is absorbed through the skin about 10x better than it is absorbed orally.(9,10,11) Most fascinating, is that the skin is extremely concentrated in the steroid converting enzymes required to convert DHEA to the androgenic/anabolic hormones listed above.(2-8) Because Dermacrine is delivered topically, It is the most effective formula possible
To help control estrogenic side effects Dermacrinen is fortified with Resveratrol and 7,8 Benzoflavone – natural aromatase inhibitors that reduce conversion to estrogen. Dermacrine to have minimal conversion to DHT, thus offering safety for those concerned with hair loss.
All this makes dermacrine a perfect add to any cycle but even better a great bridge between compounds. Allowing you to stay on cycle longer well minimizing shut down, controlling side effects, and keeping gains rolling. With Dermacrine you can safely turn a 4 week cycle into a 8 weeks cycle, or a 8 weeks cycle into a 12 weeks cycle.
Need2sleep.
With added aggression, boosted hormone levels, and extra stress on the body restlessness can some times be a problem for users. Some users reports trouble getting to sleep and being over energized at the end of the day. Needtobuildmuscle.come formulated Need2sleep to eliminate this side effect.
Sleep is the most essential aspects of our well being and health. Almost all cell regeneration and growth happens when we sleep. In other words we rest and repair when we sleep. When we don't get enough rest we don't get enough repair. When we don't get enough repair it takes its tole on our health.
A lack of regular healthy sleep slows down everything from brain function to muscle growth and its effects can be felt after just one night. When we don't get a good night sleep we feel sluggish,run down, and generally out of it untill we get the rest our bodies so desperately needs.
Not only is it important to get sleep but its equally important to get GOOD SLEEP . Uninterpreted healthy deep sleep. Often we may sleep 8-12 hours and still wake up feeling like we got no rest at all. This is because we did not fall into a deep restful sleep and stay there long enough.
Ever sleep 12 hours and feel like you didn't sleep a wink? this is because you did not reach a deep sleep or did not stay in a deep sleep long enough.
There are 2 basic stages in the sleep process. REM (Rapid Eye Movement) sleep and NREM (non-REM) sleep. NREM sleep is divided further into four sleep stages, numbered 1, 2, 3 and 4. Normal sleep begins with stage 1 and progresses into 2, 3 and 4, getting more and more deep with each stage. The deeper sleep is achieved at stages 3 and 4. (This is also the stage during which HGH and melatonin is released by the pineal gland). The fifth stage, which is actually lighter, is REM sleep, during which dreaming occurs.
The different sleep stages are also referred to as S-sleep (synchronized EEG pattern sleep) and D-sleep (desynchronized EEG pattern sleep). D-sleep is the same as REM or dream sleep; S-sleep is another name for NREM, ( also known as orthodox or quiet sleep).
The five stages of sleep:
Stage 1: As we fall asleep, we enter the transition state called stage 1 and begin our first "sleep cycle". This very light sleep stage usually lasts 2-5 minutes. If sleep remains undisturbed it will progress to stage 2 sleep. Stage 1 contributes 2-5 % of normal sleep, (but increases hugely in cases of insomnia and disorders that produce frequent arousal such as apnea) .
Stage 2: This is a much deeper sleep than stage 1. The brain waves go into theta mode, and lead into stages 3 and 4 in around 10-20 minutes. Stage 2 sleep occupies approximately 50-65% of our sleep time, lasting 15-30 minutes in each cycle.. During the latter part of the night we spend more and more time alternating between stages 2 & REM sleep.
Stage 3: A deeper sleep than stage 2. The muscles are relaxed, heart rate slows down, blood pressure falls, breathing is steady and even. Brain activity slows down dramatically from the theta pattern of stage 2 to a much slower rhythm of 1 to 2 cycles per second called 'delta', and the height, or amplitude, of the waves increases.
Stage 4: The deepest sleep of all, during which a sleeping person is 'dead to the world'. Blood pressure and heart rate fluctuate and the sleeper's brain heats up. Delta sleep is characterized by very high voltage slow brain waves. It is similar to being in a coma, but unlike a coma, it's reversible. As we transverse these first four stages of sleep our respiration and heart rate slow and the body is almost immobile.
Stage 5: REM (rapid eye movement). All of a sudden, after 20-30 minutes of slow wave sleep, we transfer back into stage 2, and almost immediately change gears into very active brain wave pattern known as REM sleep. Simultaneous with this transfer into REM, our respiration and heart rate increases substantially and we lose our ability to use our postural or skeletal muscles.
The first REM period lasts only about ten minutes. After that, the sleeper goes back into a deep stage 4 sleep. Again, the sleeper returns into a REM stage after a short period, and cycles through REM and stage 4 continue until the sleeper awakens. Along with this, our brain becomes so activated that we start to hallucinate and dream. Our eyes move as in wakefulness, and in relation to what we are dreaming. In effect, we are, at this stage ,a highly activated brain in a paralyzed body. This paradoxical state will last 10-20 minutes and then we "fall" back down into stage 2 again.
Needtobuildmuscle's Need 2 sleep is a 3 punch combo of ingredients designed to
1. promote relaxation
2. promote deep restful sleep
3. keep you in a deep restful stage of sleep longer
4. Have you waking up feeling better then ever with no groggy unnatural side effects.
The first ingredient in need 2 sleep is Valerian root. A full 400 powerful mg of it.
The major constituents of Valerian root include sesquterpenoids, valepotriates, bornyl acetate and valerenic acid. Multiple compounds in valerian root have pharmacologic activity. Valerenic acid has been shown to inhibit enzyme-induced breakdown and the inhibition of reuptake of the inhibitory neurotransmitter gamma-aminobutyric acid (gaba) in the brain. Basically this means that the brain chemical GABA can last longer and lead to sedation. Valerenic acid, an active constituent of valerian root extract, stimulates chloride currents through GABA( A) receptors. Valerenic acid is a subunit specific allosteric modulator of GABA (A) receptors that most likely interacts with the loreclezole binding pocket.
Clinical research shows that valerian root improves overall sleep quality, shortening the length of time it takes to fall asleep and helping people sleep more soundly. Overall, valerian root seems to help poor sleepers the most. In one double blind study on sleep disorders, 44 percent of the test group reported "perfect" sleep and 89 percent noted significant improvement after taking valerian root, in comparison with placebo
Lindahl O, Lindwall L. Double blind study of a valerian preparation. Pharmacology, Biochemistry & Behavior 1989; 32: 1065-1066.
The second ingredient in need 2 sleep is 6mg of Melatonin
Melatonin is a hormone produced naturally by the body in the pineal gland of the brain. The release of melatonin correlates with the body's cycle of day and night. As light inhibits its production, and darkness stimulates it, melatonin regulates the body's internal clock. Double blind research shows that this hormone helps people sleep, shortens the number of awakenings in the night, and improves the quality of sleep. melatonin exhibits positive psychological benefits on a person's mood, while a lack of melatonin corresponds to anxiety, fatigue, and hostility. In short it helps put you to sleep and bring you into a deep sleep faster.
The 3rd and final ingredient in need 2 sleep is is 5-htp 50mg
5-htp is the immediate precursor to serotonin a neurotransmitter. 5-hpt also increases endorphins our bodies natural pain killers.
5-HTP bypasses the brain's light-regulation system that controls the secretion of melatonin. 5-HTP results in the increased the production of neurotransmitters such as serotonin and norepinephrine that stimulate the noradrenergic receptors in the brain. This stimulation directly triggers the production and release of melatonin, helps relax the body,and prevents iritating pain from keeping you awake.
Combined, the ingredients in need2sleep are a proven powerful sleep aid. Need2sleep will put you to sleep fast and give you the good nights rest your body needs.
Sustain alpha
Sustain alpha is a powerful pct product that brings back your bodies natural test production and helps normalized your bodies hormone levels.
Sustain Alpha increases GrRH release by preventing the negative feedback of steroid hormones on the hypothalamus through GABAergic modulation and estrogen blockage.
In other words, Sustain Alpha offsets the suppression of steroid hormones in the brain, allowing the body to produce more testosterone than it normally would, by up-regulating GnRH and LH & FSH.
Sustain Alpha pushes LH & FSH even higher by direct aromatic stimulation of the hypothalamic and pituitary cells. This is accomplished with natural volatile oils that absorb and penetrate directly into the hypothalamic region upon inhalation.
* Remember, maintaining normal levels of estrogen is an important part of maintaining libido, muscle recovery, and testicular function. Therefore, it is undesirable to overly suppress estrogen levels. The natural anti-estrogens in Sustain Alpha gently balance and control estrogen levels, without overly suppressing them
Combining sustain alpha with Our (Forged post cycle) For one of the most powerful pct’s ever.
Forged post cycle.
This product combines proven ingredients that boost testosterone, raise free test levels, and restore normal hormonal production.
Forged post cycle contains Bulgarian Tribulus terrestris, 3,4-divanillyltetrahydrofuran,Fenugreek,Indole-3-Carbinole and Chrysin.
The first ingredients In forged post cycle is 3,4-divanillyltetrahydrofuran
This has been proven to raise your bodies free test. Within the human body is a globular protein called Sex Hormone Binding Globulin (SHBG). SHBG binds to male androgens such as testosterone, rendering that testosterone “inactive.” That is, it makes it impossible for testosterone to bind to the androgen receptor and stimulate muscle cell growth. This is not good for people coming off a cycle and trying to keep muscle gains,, SHBG naturally binds over 90% of your testosterone! Making what little test you have going into pct almost useless.
Forged post cycle utilizeses the highest 95% pure extract available today of a lignan contained in nettle root called 3,4-divanillyltetrahydrofuran. 3,4-divanillyltetrahydrofuran has a very strong binding affinity to SHBG, making it next to impossible for SHBG to bind with testosterone. What This does Is make every once of test in your body during pct count. As you are in the first stages of pct your test is always low. So making sure every drop of it is not wasted is crucial to recovery. Making the most of the test you have is important during the fist stages of pct when test is low, and it’s a known fact that shbg is at its highest at the end of most hormone cycles. So lowering shbg would only seem smart.
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/-)-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
The next ingredient in Forged post cycle is Bulgarian Tribulus terrestris
Tribulus Terrestris causes your body to release luteinizing
hormone, which in turn then signals your testicles to
naturally produce more testosterone. Studies have shown over 50% increase in testosterone levels when taking a pure form of Tribulus Terresteris.
There has been much talk across the internet and on bodybuilding forums
About tribuluse and like anything everyone has there opinion. Some supplement companies clam it’s the greatest supplement ever and then some self proclaimed board gurus Claim its completely worthless.
Coming somewhere in the middle is the truth that Pure tribulus promotes recovery and aids in the pct process. Not only that but gives some added benefits like boosted sex drive and mood.
The 3rd proven ingredient in forged post cycle is Fenugreek
During a Designer supplement cycle it is always wise to use a liver sup (more on this later) but even after a cycle it is good to help the liver recover from the stress that you just put it threw. Your liver processes everything from Protein to estrogen. Every hormone is metabolized threw the liver. So Optamel liver function is of the utmost importance when coming off cycle. Repairing and rebuilding the liver after a harsh oral cycle is always a smart choice. Fenugreek has been proven to not only protect but (ready) repair liver damage
Alcohol Alcohol. 2006 May-Jun;41(3):267-73. Epub 2006 Mar 30. Links
Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells.Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The protective effect of a polyphenolic extract of fenugreek seeds (FPEt) against ethanol (EtOH)-induced toxicity was investigated in human Chang liver cells. Cells were incubated with either 30 mM EtOH alone or together in the presence of seed extract for 24 h. Assays were performed in treated cells to evaluate the ability of seeds to prevent the toxic effects of EtOH. EtOH treatment suppressed the growth of Chang liver cells and induced cytotoxicity, oxygen radical formation and mitochondrial dysfunction. Reduced glutathione (GSH) concentration was decreased significantly (P < 0.05) while oxidized glutathione (GSSG) concentration was significantly elevated in EtOH-treated cells as compared with normal cells. Incubation of FPEt along with EtOH significantly increased cell viability in a dose-dependent manner, caused a reduction in lactate dehydrogenase leakage and normalized GSH/GSSG ratio. The extract dose-dependently reduced thiobarbituric acid reactive substances formation. Apoptosis was observed in EtOH-treated cells while FPEt reduced apoptosis by decreasing the accumulation of sub-G1 phase cells. The cytoprotective effects of FPEt were comparable with those of a positive control silymarin, a known hepatoprotective agent. The findings suggest that the polyphenolic compounds of fenugreek seeds can be considered cytoprotective during EtOH-induced liver damage.
PMID: 16574673 [PubMed - indexed for MEDLINE]
1: Pharmazie. 2007 Apr;62(4):299-304.Links
Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis.Kaviarasan S, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The present study investigates the hepatoprotective effect of fenugreek seed polyphenolic extract (FPEt) against ethanol-induced hepatic injury and apoptosis in rats. Chronic ethanol administration (6 g/kg/day x 60 days) caused liver damage that was manifested by the elevation of markers of liver dysfunction--aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and gamma-glutamyl transferase (GGT) in plasma and reduction in liver glycogen. The effects on alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied and found to be altered in the alcohol-treated group. Ethanol administration resulted in adaptive induction of the activities of cytochrome p450 (cyt-p-450) and cytochrome-b5 (cyt-b5) and reduction in cytochrome-c-reductase (cyt-c-red) and glutathione-S-tranferase (GST), a phase II enzyme. Further, ethanol reduced the viability of isolated hepatocytes (ex vivo) as assessed by the trypan blue exclusion test and increased hepatocyte apoptosis as assessed by propidium iodide staining (PI). Treatment with FPEt restored the levels of markers of liver injury and mitigated the alterations in alcohol metabolizing and detoxification enzymes and the electron transport component cytochrome-c reductase. Increased hepatocyte viability and reduced apoptotic nuclei were observed in FPEt-treated rats. These findings demonstrate that FPEt acts as a protective agent against ethanol-induced abnormalities in the liver. The effects of FPEt are comparable with those of a known hepatoprotective agent, silymarin.
PMID: 17484288 [PubMed - indexed for MEDLINE]
1: Cell Biol Toxicol. 2007 Apr 24 [Epub ahead of print] Links
Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver.Kaviarasan S, Viswanathan P, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India, [email protected].
Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co-administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.
PMID: 17453353 [PubMed - as supplied by publisher]
1: Phytother Res. 2003 Aug;17(7):737-43. Links
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity.Thirunavukkarasu V, Anuradha CV, Viswanathan P.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The study investigates the effect of aqueous extract of fenugreek seeds (Trigonella foenum graecum) on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats. The ability of the seed extract to prevent iron-induced lipid peroxidation in vitro was also investigated. Ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. The levels of serum lipid hydroperoxides and thiobarbituric acid reactive substances in liver and brain were also significantly elevated. Significantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and alpha-tocopherol concentrations. Activity of Ca(2+) ATPase in brain was significantly lowered. Simultaneous administration of aqueous extract of fenugreek seeds with ethanol prevented the enzymatic leakage and the rise in lipid peroxidation and enhanced the antioxidant potential. The seeds exhibited appreciable antioxidant property in vitro which was comparable with that of reduced glutathione and alpha-tocopherol. Further, histopathological examination of liver and brain revealed that, aqueous extract of fenugreek seeds could offer a significant protection against ethanol toxicity. Copyright 2003 John Wiley & Sons, Ltd.
PMID: 12916070 [PubMed - indexed for MEDLINE]
healthy glucose levels and healthy sugar metabolism By
assisting the pancreas in production of insulin
the active compounds 4-hydroxyisoleucine In of fenugreek is an amino acid derivative that assists the pancreas in production of insulin. Studies have shown 4-hydroxyisoleucine reduces fasting blood sugars and improves after-meal glucose tolerance significantly. 4-hydroxyisoleucine works by two separate mechanisms: It has a direct, stimulating effect on insulin production for those who wish to increase their glucose metabolism and helps to reduce glucose resistance and the uptake of glucose, thereby reducing overall blood glucose levels. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing postmeal glucose levels—with little or no increase in blood insulin concentrations— a clear indictor of improved insulin sensitivity
Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin-promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4 -hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production. Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time
And finely some studies of shown that fenugreek can raise the bodies natural testosterone
The last ingredients in forged post cycle are Indole-3-Carbinole and Chrysin. To reduce estrogen which is often elevated after a cycle of designer supplement. This ingredients of shown in many studies to effectively reduce estrogen levels.
Forged liver support
The ingredients in Forged liver support are perfectly formulated to protect the liver during Designer supplement cycles.
First N-acetyl-L-Cysteine (NAC. This is what is given to poison victims to protect their livers, and it
has been well accepted by the medical community as a very powerful antioxidant. It should go without saying that antioxidants are crucial in preventing damage done to the body by free radicals. Free radicals often arise when compounds are detoxified. This is often the case during a disgner supplement cycle.
Though, what often isn't talked about is that our bodies make some antioxidants, and others we can only get from the foods we eat, especially fruits and vegetables. And while most of these have yet been classified as essential, as vitamins, it may only be because enough studies haven't been done yet. But who knows how much those antioxidants you may not be getting
enough of have an effect on preventing diseases like cancer and the effects of old age. Or worse liver damage well running a liver stressing cycle.
In addition to NAC Forged liver support has several other powerful antioxidants that have been studied specifically for their beneficial
effect on the liver. Milk thistle has been demonstrated in studies to reduce liver inflammation and improve liver function in patients with liver disease.
Another antioxidant included is the herb Astragalus, a type of bean that has been used in Chinese medicine for over
2,000 years. Among its many curative properties, the Chinese used this for treating the liver. Research in the past decade has
focused on its effect on the liver, fighting viral infections, and its role in the treatment of cancer. Interestingly an extract has
been shown to prevent the shortening of telomeres, which are the caps on DNA that keep cells young.
Next up is Phosphatidylcholine, which is another big gun supplement for the liver. This is a great bioactive form of the essential B vitamin Choline. This supplement is a key component of cell membranes as well as the molecules that transport fat out of the liver. High concentrations are found in the brain and liver. As a result it has been used as support in Alzheimer's, depression, and other brain disorders. Deficiency in the diet can lead to liver disease, and supplementation is
used for individuals with liver disease or damage.
Regulating cholesterol levels in the body is a large function of the liver. So to provide extra support Forged liver support has red yeast rice,
which contains chemicals similar to those in cholesterol medications for reducing cholesterol levels in the body.
Forged liver support is the ultimo All in one liver support and liver function supplement. Froged liver support covers it all.
Now that we have covered all of our Designer supplements, cycle enhancers, support supplements, and pct products in depth let us get down to the fun stuff. The stacks!!!!!!!!!!!!!!
The beastdrol Starter stack.
1 bestdrol
1 19-Tren-Tfo
1 Forged liver support
1 Forged post cycle
How to cycle the stack
Weeks
1-4 1 cap beastdrol 3 times daily
1-4 1 cap 19-tren-tfo 3 times daily
1-4 forged liver support 2 caps Am daily
4-8 forged post cycle 2 Am caps every day.
The beastdrol+katanadrol shredder stack,
1 beastdrol
1 katanadrol
1 forged liver support
1 forged post cycle
How to cycle the stack
1-4 beastdrol 1 cap 3 times a day
1-4 katanadrol 1 cap 3 times daily
1-4 forged liver support 2 caps daily
4-8 forged post cycle 2 caps Am daily
The master cyclists stack.
1 deiselbolan
1 beastdrol
1 katanadrol
1 19-tren-tfo
2 forged liver supports
1 forged post cycle
1 sustain alpha
1 dermacrine
How to cycle the stack.
Weeks
1-4 Deiselbolan 1 cap 3 times daily
1-4 katanadrol 1 cap 3 times daily
1-4 forged liver support 2 caps daily
4-8 Dermacrin bridge 5 pumps daily
8-12 beastdrol 1 cap 3 times daily
8-12 19-tren tfo 1 cap 3 times daily
8-12 forged liver support 2 caps daily
12-16 forged post cycle support 2 caps daily
12-16 sustain alpha 5 pumps Am daily
1. What are Designer supplements?
Designer supplements are used by athletes looking to increase size, strength, endurance, reduce recovery time or add lean body mass. They are most often used for increasing muscle mass or reducing bodyfat levels. Life extension groups are also increasingly using designer supplements as a means of hormone replacement therapy, as an alternative to prescription drug use. A trustworthy Company Will clearly indicate what is in there products on there label and there web site. It may seem like a lot of mobo jumbo to you at first when you see compounds like
19-Norandrosta 4,9 diene- 3,17 dione
2a, 17a-dimethyl-5a-androst-3-one-17b-ol
13 ethyl 3 methoxy
17a-methyl-etioallocholan-2-ene 17b-ol
4-chloro-17a-methyl-androst-1,4- diene-3-17b-dio
But if you take this information and search the internet or bodybuilding forums like (elitefitness.com) You will quickly start to understand what each compound is and how it works.
2 .Do they have side effects?
Yes. Designer supplements can have the same side effects as any anabolic compound, and are dependent upon the user as to which side effects one might experience. Some side effects are acne, hair loss, breast tissue enlargement, and prostate swelling. The potential for these side effects does exist, but it can be reduced if one uses proper precautionary measures (Which we explain for you). Generally, if a person is genetically predisposed to a side effect it will occur (i.e.: if someone has a history of male pattern baldness in the family, it could be assumed that this could be a side effect experienced if certain Designer hormones are used). Needtobuildmuscle.com carries the most cutting edge support sups that are commonly excepted to help reduce side effects from designer Hormone cycles. It is recommended that you always consult your physician before using Designer supplements
5. How do Designer supplements work?
1. Each Designer supplement works in different ways but the end results of each Designer supplement process is it attaches to an androgen receptor in the cells of your body. This in turn increases nitrogen retention and protein synthesis, meaning that your body is in a constant anabolic state (assuming you are continuously supplying your body with the supplement).
Here is a list of this months needtobuildmuscle.com’s featured Designer supplements with full detailed descriptions of there use and effectiveness.
Katanadrol
Like the mighty katana Katanadrol is the king of cutting. With the power of Katanadrol you can be like the katana blade.Thin yet deadly powerful. Sleek yet unbreakable as carbon steel.
Katanadrol active ingredients
19-Norandrosta 4,9 diene- 3,17 dione 40mg per cap 4-chloro-17a-methyl-androst-1,4- diene-3-17b-dio 10mg per cap 90 capsules per bottle
Using Katanadrol and expected results.
Dosage 2-3 cap every day Spread out evenly
Katanadrol is a great designer supplement for people looking to drop body fat well still maintaining muscle size and strength. People competing in weight classed events will find that Katanadrol can give them the extra strength and speed they need with out adding to much bulk. All gains with Katanadrol are lean and hard.
Katanadrol can be added to almost any Designer supplement stack adding muscle strength and fat lose properties to the stack.
19-Tren-Tfo
19 tren Tfo Is the ultimate stacking Designer supplements. It is non methylated therefore it adds no extra stress to the liver or the body. It can not convert to estrogen
Or dht so it will not cause any bloat or problems with lipid profiles. Raising hormone
It will add lean muscle and strength on its one but it’s the most synergistic stacking compound to date.
19-tren-tfo
Using Tren-tfo and expected results.
Dosage 2-3 cap every day Spread out evenly
Tfo will give good strength and size gains for any users on its own. Designer supplement beginners have reported great gains using Tfo on its own and advanced users report fairly good gains as well.
The real power of Tren-tfo lies in its synergistic stacking power. When added to any stack it magnifies gains. From adding more bulk to a bulking stack to aiding in fat burning in a cutting stack. There is no question Tfo is the king of stacking.
Deiselbolan
Deiselbolan is a super charged muscle building combo designed to help you gain muscle while staying lean. Work out longer lift stronger and break through plateaus with Deiselbolan. It helps prevent muscle brake down after work outs. Deiselbolan has Massive nutrition retention power. The more you feed your muscles well on dieselbolan the more they will grow. Deiselbolan packs on muscle mass. Bulking is the name of the gain. With the synergistic combo of compounds in Deiselbolan it is not your typical sloppy bulk. Gains are big yet clean. Bloat is kept to a minimum if any at all.
Deiselbolan active ingredients
Ingredients per cap.
13 ethyl 3 methoxy, 25mg
17a-methyl-etioallocholan-2-ene 17b-ol 15mg
90ct bottle
Using deiselbolan and expected results.
Dosage 2-3 cap every day Spread out evenly.
Deiselbolan builds mass plan and simple. Threw nutrition retention, Anabolic Ar activity, Fast muscle recovery, And enhanced muscle endurance Deiselbolan packs on the mass like no other.
Deiselbolan Is the perfect base compound for any cycle. Use it in as a stand alone bulking products. A base compound for a bulking cycle, or As the kick start to a lean mass cycle as well.
Beastdrol
is a powerful product that commands respect. Strength gains with beastdrol are truly Amazing, and all the gains in size are lean and hard. Many people report a good amount of size with an incredible amount of strength as well. Every once of muscle gained is lean and rock hard.
Beastdrol active ingredients
2a, 17a-dimethyl-5a-androst-3-one-17b-ol 10mg per pill
L-Carnintine L-Tartrate 500mgs per pill
Using Beastdrol and expected results.
Dosage 2-3 cap every day Spread out evenly
All the gains from beastdrol are rock solid and hard. Good muscle size has been reported using Beastdrol and Fierce strength gains are common. Beastdrol is a great stand alone Designer supplement. When stacking bestdrol in cycles the possibility are endless. Use it to harden up gains at the end of a bulk. Combine it with other compounds to gain massive amounts of muscle and strength, and much more.
Designer supplement cycle Enhancers, support susp, and pct products.
What are cycle enhancers, support supplements, and pct products?
Anything that adds to the the cycles gains, Reduces it’s sides, Enhances its effects or the users overall feeling, health, or state of mind. Also any product that helps the user fully recover from the cycle mentally, hormonally, and Physically. Needtobuildmuscle.com offers a number of these products for out users. And we are always on the cutting edge searching for new and exciting products. Here is a list of Needtobuildmuscle.coms cycle enhancers , support supplements , and pct products.
Dermacrine
Dermacrine helps support a raging sex drive, aggressive mental focus, and an intense appetite. It helps prevent The lethargic feeling that is some times common with Designer supplements. Many don’t realize that there are over a dozen different natural hormones which act like testosterone to positively influence muscle gains, strength and libido.(1) Dermacrine delivers a hefty dose of DHEA and Pregenenolone, bio-identical precursors for the essential male hormones. More specifically, DHEA readily converts to the hormones androstenedione, androstenediol, and androsterone.(2-8) These are known as anabolic/androgenic hormones that are responsible for “all that is man” including libido, muscular development, aggression and recovery. Therefore, it is important to keep these hormones elevated with Dermacrine, especially during a steroid cycle when the production of these natural hormones are shut down!
Consider this -- DHEA is absorbed through the skin about 10x better than it is absorbed orally.(9,10,11) Most fascinating, is that the skin is extremely concentrated in the steroid converting enzymes required to convert DHEA to the androgenic/anabolic hormones listed above.(2-8) Because Dermacrine is delivered topically, It is the most effective formula possible
To help control estrogenic side effects Dermacrinen is fortified with Resveratrol and 7,8 Benzoflavone – natural aromatase inhibitors that reduce conversion to estrogen. Dermacrine to have minimal conversion to DHT, thus offering safety for those concerned with hair loss.
All this makes dermacrine a perfect add to any cycle but even better a great bridge between compounds. Allowing you to stay on cycle longer well minimizing shut down, controlling side effects, and keeping gains rolling. With Dermacrine you can safely turn a 4 week cycle into a 8 weeks cycle, or a 8 weeks cycle into a 12 weeks cycle.
Need2sleep.
With added aggression, boosted hormone levels, and extra stress on the body restlessness can some times be a problem for users. Some users reports trouble getting to sleep and being over energized at the end of the day. Needtobuildmuscle.come formulated Need2sleep to eliminate this side effect.
Sleep is the most essential aspects of our well being and health. Almost all cell regeneration and growth happens when we sleep. In other words we rest and repair when we sleep. When we don't get enough rest we don't get enough repair. When we don't get enough repair it takes its tole on our health.
A lack of regular healthy sleep slows down everything from brain function to muscle growth and its effects can be felt after just one night. When we don't get a good night sleep we feel sluggish,run down, and generally out of it untill we get the rest our bodies so desperately needs.
Not only is it important to get sleep but its equally important to get GOOD SLEEP . Uninterpreted healthy deep sleep. Often we may sleep 8-12 hours and still wake up feeling like we got no rest at all. This is because we did not fall into a deep restful sleep and stay there long enough.
Ever sleep 12 hours and feel like you didn't sleep a wink? this is because you did not reach a deep sleep or did not stay in a deep sleep long enough.
There are 2 basic stages in the sleep process. REM (Rapid Eye Movement) sleep and NREM (non-REM) sleep. NREM sleep is divided further into four sleep stages, numbered 1, 2, 3 and 4. Normal sleep begins with stage 1 and progresses into 2, 3 and 4, getting more and more deep with each stage. The deeper sleep is achieved at stages 3 and 4. (This is also the stage during which HGH and melatonin is released by the pineal gland). The fifth stage, which is actually lighter, is REM sleep, during which dreaming occurs.
The different sleep stages are also referred to as S-sleep (synchronized EEG pattern sleep) and D-sleep (desynchronized EEG pattern sleep). D-sleep is the same as REM or dream sleep; S-sleep is another name for NREM, ( also known as orthodox or quiet sleep).
The five stages of sleep:
Stage 1: As we fall asleep, we enter the transition state called stage 1 and begin our first "sleep cycle". This very light sleep stage usually lasts 2-5 minutes. If sleep remains undisturbed it will progress to stage 2 sleep. Stage 1 contributes 2-5 % of normal sleep, (but increases hugely in cases of insomnia and disorders that produce frequent arousal such as apnea) .
Stage 2: This is a much deeper sleep than stage 1. The brain waves go into theta mode, and lead into stages 3 and 4 in around 10-20 minutes. Stage 2 sleep occupies approximately 50-65% of our sleep time, lasting 15-30 minutes in each cycle.. During the latter part of the night we spend more and more time alternating between stages 2 & REM sleep.
Stage 3: A deeper sleep than stage 2. The muscles are relaxed, heart rate slows down, blood pressure falls, breathing is steady and even. Brain activity slows down dramatically from the theta pattern of stage 2 to a much slower rhythm of 1 to 2 cycles per second called 'delta', and the height, or amplitude, of the waves increases.
Stage 4: The deepest sleep of all, during which a sleeping person is 'dead to the world'. Blood pressure and heart rate fluctuate and the sleeper's brain heats up. Delta sleep is characterized by very high voltage slow brain waves. It is similar to being in a coma, but unlike a coma, it's reversible. As we transverse these first four stages of sleep our respiration and heart rate slow and the body is almost immobile.
Stage 5: REM (rapid eye movement). All of a sudden, after 20-30 minutes of slow wave sleep, we transfer back into stage 2, and almost immediately change gears into very active brain wave pattern known as REM sleep. Simultaneous with this transfer into REM, our respiration and heart rate increases substantially and we lose our ability to use our postural or skeletal muscles.
The first REM period lasts only about ten minutes. After that, the sleeper goes back into a deep stage 4 sleep. Again, the sleeper returns into a REM stage after a short period, and cycles through REM and stage 4 continue until the sleeper awakens. Along with this, our brain becomes so activated that we start to hallucinate and dream. Our eyes move as in wakefulness, and in relation to what we are dreaming. In effect, we are, at this stage ,a highly activated brain in a paralyzed body. This paradoxical state will last 10-20 minutes and then we "fall" back down into stage 2 again.
Needtobuildmuscle's Need 2 sleep is a 3 punch combo of ingredients designed to
1. promote relaxation
2. promote deep restful sleep
3. keep you in a deep restful stage of sleep longer
4. Have you waking up feeling better then ever with no groggy unnatural side effects.
The first ingredient in need 2 sleep is Valerian root. A full 400 powerful mg of it.
The major constituents of Valerian root include sesquterpenoids, valepotriates, bornyl acetate and valerenic acid. Multiple compounds in valerian root have pharmacologic activity. Valerenic acid has been shown to inhibit enzyme-induced breakdown and the inhibition of reuptake of the inhibitory neurotransmitter gamma-aminobutyric acid (gaba) in the brain. Basically this means that the brain chemical GABA can last longer and lead to sedation. Valerenic acid, an active constituent of valerian root extract, stimulates chloride currents through GABA( A) receptors. Valerenic acid is a subunit specific allosteric modulator of GABA (A) receptors that most likely interacts with the loreclezole binding pocket.
Clinical research shows that valerian root improves overall sleep quality, shortening the length of time it takes to fall asleep and helping people sleep more soundly. Overall, valerian root seems to help poor sleepers the most. In one double blind study on sleep disorders, 44 percent of the test group reported "perfect" sleep and 89 percent noted significant improvement after taking valerian root, in comparison with placebo
Lindahl O, Lindwall L. Double blind study of a valerian preparation. Pharmacology, Biochemistry & Behavior 1989; 32: 1065-1066.
The second ingredient in need 2 sleep is 6mg of Melatonin
Melatonin is a hormone produced naturally by the body in the pineal gland of the brain. The release of melatonin correlates with the body's cycle of day and night. As light inhibits its production, and darkness stimulates it, melatonin regulates the body's internal clock. Double blind research shows that this hormone helps people sleep, shortens the number of awakenings in the night, and improves the quality of sleep. melatonin exhibits positive psychological benefits on a person's mood, while a lack of melatonin corresponds to anxiety, fatigue, and hostility. In short it helps put you to sleep and bring you into a deep sleep faster.
The 3rd and final ingredient in need 2 sleep is is 5-htp 50mg
5-htp is the immediate precursor to serotonin a neurotransmitter. 5-hpt also increases endorphins our bodies natural pain killers.
5-HTP bypasses the brain's light-regulation system that controls the secretion of melatonin. 5-HTP results in the increased the production of neurotransmitters such as serotonin and norepinephrine that stimulate the noradrenergic receptors in the brain. This stimulation directly triggers the production and release of melatonin, helps relax the body,and prevents iritating pain from keeping you awake.
Combined, the ingredients in need2sleep are a proven powerful sleep aid. Need2sleep will put you to sleep fast and give you the good nights rest your body needs.
Sustain alpha
Sustain alpha is a powerful pct product that brings back your bodies natural test production and helps normalized your bodies hormone levels.
Sustain Alpha increases GrRH release by preventing the negative feedback of steroid hormones on the hypothalamus through GABAergic modulation and estrogen blockage.
In other words, Sustain Alpha offsets the suppression of steroid hormones in the brain, allowing the body to produce more testosterone than it normally would, by up-regulating GnRH and LH & FSH.
Sustain Alpha pushes LH & FSH even higher by direct aromatic stimulation of the hypothalamic and pituitary cells. This is accomplished with natural volatile oils that absorb and penetrate directly into the hypothalamic region upon inhalation.
* Remember, maintaining normal levels of estrogen is an important part of maintaining libido, muscle recovery, and testicular function. Therefore, it is undesirable to overly suppress estrogen levels. The natural anti-estrogens in Sustain Alpha gently balance and control estrogen levels, without overly suppressing them
Combining sustain alpha with Our (Forged post cycle) For one of the most powerful pct’s ever.
Forged post cycle.
This product combines proven ingredients that boost testosterone, raise free test levels, and restore normal hormonal production.
Forged post cycle contains Bulgarian Tribulus terrestris, 3,4-divanillyltetrahydrofuran,Fenugreek,Indole-3-Carbinole and Chrysin.
The first ingredients In forged post cycle is 3,4-divanillyltetrahydrofuran
This has been proven to raise your bodies free test. Within the human body is a globular protein called Sex Hormone Binding Globulin (SHBG). SHBG binds to male androgens such as testosterone, rendering that testosterone “inactive.” That is, it makes it impossible for testosterone to bind to the androgen receptor and stimulate muscle cell growth. This is not good for people coming off a cycle and trying to keep muscle gains,, SHBG naturally binds over 90% of your testosterone! Making what little test you have going into pct almost useless.
Forged post cycle utilizeses the highest 95% pure extract available today of a lignan contained in nettle root called 3,4-divanillyltetrahydrofuran. 3,4-divanillyltetrahydrofuran has a very strong binding affinity to SHBG, making it next to impossible for SHBG to bind with testosterone. What This does Is make every once of test in your body during pct count. As you are in the first stages of pct your test is always low. So making sure every drop of it is not wasted is crucial to recovery. Making the most of the test you have is important during the fist stages of pct when test is low, and it’s a known fact that shbg is at its highest at the end of most hormone cycles. So lowering shbg would only seem smart.
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/-)-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-)-pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4-divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
The next ingredient in Forged post cycle is Bulgarian Tribulus terrestris
Tribulus Terrestris causes your body to release luteinizing
hormone, which in turn then signals your testicles to
naturally produce more testosterone. Studies have shown over 50% increase in testosterone levels when taking a pure form of Tribulus Terresteris.
There has been much talk across the internet and on bodybuilding forums
About tribuluse and like anything everyone has there opinion. Some supplement companies clam it’s the greatest supplement ever and then some self proclaimed board gurus Claim its completely worthless.
Coming somewhere in the middle is the truth that Pure tribulus promotes recovery and aids in the pct process. Not only that but gives some added benefits like boosted sex drive and mood.
The 3rd proven ingredient in forged post cycle is Fenugreek
During a Designer supplement cycle it is always wise to use a liver sup (more on this later) but even after a cycle it is good to help the liver recover from the stress that you just put it threw. Your liver processes everything from Protein to estrogen. Every hormone is metabolized threw the liver. So Optamel liver function is of the utmost importance when coming off cycle. Repairing and rebuilding the liver after a harsh oral cycle is always a smart choice. Fenugreek has been proven to not only protect but (ready) repair liver damage
Alcohol Alcohol. 2006 May-Jun;41(3):267-73. Epub 2006 Mar 30. Links
Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells.Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The protective effect of a polyphenolic extract of fenugreek seeds (FPEt) against ethanol (EtOH)-induced toxicity was investigated in human Chang liver cells. Cells were incubated with either 30 mM EtOH alone or together in the presence of seed extract for 24 h. Assays were performed in treated cells to evaluate the ability of seeds to prevent the toxic effects of EtOH. EtOH treatment suppressed the growth of Chang liver cells and induced cytotoxicity, oxygen radical formation and mitochondrial dysfunction. Reduced glutathione (GSH) concentration was decreased significantly (P < 0.05) while oxidized glutathione (GSSG) concentration was significantly elevated in EtOH-treated cells as compared with normal cells. Incubation of FPEt along with EtOH significantly increased cell viability in a dose-dependent manner, caused a reduction in lactate dehydrogenase leakage and normalized GSH/GSSG ratio. The extract dose-dependently reduced thiobarbituric acid reactive substances formation. Apoptosis was observed in EtOH-treated cells while FPEt reduced apoptosis by decreasing the accumulation of sub-G1 phase cells. The cytoprotective effects of FPEt were comparable with those of a positive control silymarin, a known hepatoprotective agent. The findings suggest that the polyphenolic compounds of fenugreek seeds can be considered cytoprotective during EtOH-induced liver damage.
PMID: 16574673 [PubMed - indexed for MEDLINE]
1: Pharmazie. 2007 Apr;62(4):299-304.Links
Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis.Kaviarasan S, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The present study investigates the hepatoprotective effect of fenugreek seed polyphenolic extract (FPEt) against ethanol-induced hepatic injury and apoptosis in rats. Chronic ethanol administration (6 g/kg/day x 60 days) caused liver damage that was manifested by the elevation of markers of liver dysfunction--aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and gamma-glutamyl transferase (GGT) in plasma and reduction in liver glycogen. The effects on alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied and found to be altered in the alcohol-treated group. Ethanol administration resulted in adaptive induction of the activities of cytochrome p450 (cyt-p-450) and cytochrome-b5 (cyt-b5) and reduction in cytochrome-c-reductase (cyt-c-red) and glutathione-S-tranferase (GST), a phase II enzyme. Further, ethanol reduced the viability of isolated hepatocytes (ex vivo) as assessed by the trypan blue exclusion test and increased hepatocyte apoptosis as assessed by propidium iodide staining (PI). Treatment with FPEt restored the levels of markers of liver injury and mitigated the alterations in alcohol metabolizing and detoxification enzymes and the electron transport component cytochrome-c reductase. Increased hepatocyte viability and reduced apoptotic nuclei were observed in FPEt-treated rats. These findings demonstrate that FPEt acts as a protective agent against ethanol-induced abnormalities in the liver. The effects of FPEt are comparable with those of a known hepatoprotective agent, silymarin.
PMID: 17484288 [PubMed - indexed for MEDLINE]
1: Cell Biol Toxicol. 2007 Apr 24 [Epub ahead of print] Links
Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver.Kaviarasan S, Viswanathan P, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India, [email protected].
Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co-administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.
PMID: 17453353 [PubMed - as supplied by publisher]
1: Phytother Res. 2003 Aug;17(7):737-43. Links
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity.Thirunavukkarasu V, Anuradha CV, Viswanathan P.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The study investigates the effect of aqueous extract of fenugreek seeds (Trigonella foenum graecum) on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats. The ability of the seed extract to prevent iron-induced lipid peroxidation in vitro was also investigated. Ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. The levels of serum lipid hydroperoxides and thiobarbituric acid reactive substances in liver and brain were also significantly elevated. Significantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and alpha-tocopherol concentrations. Activity of Ca(2+) ATPase in brain was significantly lowered. Simultaneous administration of aqueous extract of fenugreek seeds with ethanol prevented the enzymatic leakage and the rise in lipid peroxidation and enhanced the antioxidant potential. The seeds exhibited appreciable antioxidant property in vitro which was comparable with that of reduced glutathione and alpha-tocopherol. Further, histopathological examination of liver and brain revealed that, aqueous extract of fenugreek seeds could offer a significant protection against ethanol toxicity. Copyright 2003 John Wiley & Sons, Ltd.
PMID: 12916070 [PubMed - indexed for MEDLINE]
healthy glucose levels and healthy sugar metabolism By
assisting the pancreas in production of insulin
the active compounds 4-hydroxyisoleucine In of fenugreek is an amino acid derivative that assists the pancreas in production of insulin. Studies have shown 4-hydroxyisoleucine reduces fasting blood sugars and improves after-meal glucose tolerance significantly. 4-hydroxyisoleucine works by two separate mechanisms: It has a direct, stimulating effect on insulin production for those who wish to increase their glucose metabolism and helps to reduce glucose resistance and the uptake of glucose, thereby reducing overall blood glucose levels. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing postmeal glucose levels—with little or no increase in blood insulin concentrations— a clear indictor of improved insulin sensitivity
Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin-promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4 -hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production. Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time
And finely some studies of shown that fenugreek can raise the bodies natural testosterone
The last ingredients in forged post cycle are Indole-3-Carbinole and Chrysin. To reduce estrogen which is often elevated after a cycle of designer supplement. This ingredients of shown in many studies to effectively reduce estrogen levels.
Forged liver support
The ingredients in Forged liver support are perfectly formulated to protect the liver during Designer supplement cycles.
First N-acetyl-L-Cysteine (NAC. This is what is given to poison victims to protect their livers, and it
has been well accepted by the medical community as a very powerful antioxidant. It should go without saying that antioxidants are crucial in preventing damage done to the body by free radicals. Free radicals often arise when compounds are detoxified. This is often the case during a disgner supplement cycle.
Though, what often isn't talked about is that our bodies make some antioxidants, and others we can only get from the foods we eat, especially fruits and vegetables. And while most of these have yet been classified as essential, as vitamins, it may only be because enough studies haven't been done yet. But who knows how much those antioxidants you may not be getting
enough of have an effect on preventing diseases like cancer and the effects of old age. Or worse liver damage well running a liver stressing cycle.
In addition to NAC Forged liver support has several other powerful antioxidants that have been studied specifically for their beneficial
effect on the liver. Milk thistle has been demonstrated in studies to reduce liver inflammation and improve liver function in patients with liver disease.
Another antioxidant included is the herb Astragalus, a type of bean that has been used in Chinese medicine for over
2,000 years. Among its many curative properties, the Chinese used this for treating the liver. Research in the past decade has
focused on its effect on the liver, fighting viral infections, and its role in the treatment of cancer. Interestingly an extract has
been shown to prevent the shortening of telomeres, which are the caps on DNA that keep cells young.
Next up is Phosphatidylcholine, which is another big gun supplement for the liver. This is a great bioactive form of the essential B vitamin Choline. This supplement is a key component of cell membranes as well as the molecules that transport fat out of the liver. High concentrations are found in the brain and liver. As a result it has been used as support in Alzheimer's, depression, and other brain disorders. Deficiency in the diet can lead to liver disease, and supplementation is
used for individuals with liver disease or damage.
Regulating cholesterol levels in the body is a large function of the liver. So to provide extra support Forged liver support has red yeast rice,
which contains chemicals similar to those in cholesterol medications for reducing cholesterol levels in the body.
Forged liver support is the ultimo All in one liver support and liver function supplement. Froged liver support covers it all.
Now that we have covered all of our Designer supplements, cycle enhancers, support supplements, and pct products in depth let us get down to the fun stuff. The stacks!!!!!!!!!!!!!!
The beastdrol Starter stack.
1 bestdrol
1 19-Tren-Tfo
1 Forged liver support
1 Forged post cycle
How to cycle the stack
Weeks
1-4 1 cap beastdrol 3 times daily
1-4 1 cap 19-tren-tfo 3 times daily
1-4 forged liver support 2 caps Am daily
4-8 forged post cycle 2 Am caps every day.
The beastdrol+katanadrol shredder stack,
1 beastdrol
1 katanadrol
1 forged liver support
1 forged post cycle
How to cycle the stack
1-4 beastdrol 1 cap 3 times a day
1-4 katanadrol 1 cap 3 times daily
1-4 forged liver support 2 caps daily
4-8 forged post cycle 2 caps Am daily
The master cyclists stack.
1 deiselbolan
1 beastdrol
1 katanadrol
1 19-tren-tfo
2 forged liver supports
1 forged post cycle
1 sustain alpha
1 dermacrine
How to cycle the stack.
Weeks
1-4 Deiselbolan 1 cap 3 times daily
1-4 katanadrol 1 cap 3 times daily
1-4 forged liver support 2 caps daily
4-8 Dermacrin bridge 5 pumps daily
8-12 beastdrol 1 cap 3 times daily
8-12 19-tren tfo 1 cap 3 times daily
8-12 forged liver support 2 caps daily
12-16 forged post cycle support 2 caps daily
12-16 sustain alpha 5 pumps Am daily
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my wife says im obsessed
