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Choosing an OC
- Thread starter JJFigure
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" Why is that? I'm curious about the method of action. And is this caffiene in general, or specifically from coffee? ".....................................Good questions. We're talking humans here, so there's very little research other than epidemiological. What this shows is that women who drink a lot of caffeine (more than 300mg per day) have higher follicular phase estradiol levels and lower conception rates. I don't think anyone can say for sure that the caffeine is reducing fertility. It may just be an interaction such that women with high early estradiol levels happen to have a craving for caffeine and therefore drink more of it. In other words, the woman may already have naturally high estrogen levels which predisposes her to drink more coffee.
None of it makes much sense. On the one hand we have high estrogen levels that interfere with the metabolism of caffeine (which you would think would cause a woman to reduce her caffeine intake), yet on the other hand we have high caffeine intake associated with high estrogen levels (for at least part of the cycle). There's something fishy going on, but I can't quite put my finger on it.
Alcohol is actually even better at reducing fertility, but I didn't really think JJ wants to get pickled every night during her competition prep??? Which reminds me, I must tell you all the tale of increased ethanol consumption AFTER discontinuing estrogen therapy.......
I doubt you'll find ormeloxifene on Rxlist or most other American-based drug sites. I don't honestly know if you can get it on prescription in America (yet...). Try a google search and see what you find?
None of it makes much sense. On the one hand we have high estrogen levels that interfere with the metabolism of caffeine (which you would think would cause a woman to reduce her caffeine intake), yet on the other hand we have high caffeine intake associated with high estrogen levels (for at least part of the cycle). There's something fishy going on, but I can't quite put my finger on it.
Alcohol is actually even better at reducing fertility, but I didn't really think JJ wants to get pickled every night during her competition prep??? Which reminds me, I must tell you all the tale of increased ethanol consumption AFTER discontinuing estrogen therapy.......
I doubt you'll find ormeloxifene on Rxlist or most other American-based drug sites. I don't honestly know if you can get it on prescription in America (yet...). Try a google search and see what you find?
The need for a safer alternative to Progestogen - Estrogen combination pills has
been felt ever since the sixties. Clearer understanding of the role of
estrogen-progesterone balance in the development of fertilized ovum and the
priming of the uterus for implantation served as the basis for developing an agent
that would prevent pregnancy by interfering with implantation but without disturbing
the hypothalamus-pituitary-ovarian axis. Researchers the world over have been
designing and synthesising non-steroidal estrogen antagonists that would act by
disturbing the delicate balance between estrogen and progesterone at the uterine
level without interfering with their synthesis or blood levels. Centchroman developed
by CDRI precisely does this.
Centchroman is a novel non-steroidal agent unrelated to any conventionally used
contraceptive. This is the only anti-implantation agent approved for clinical use in
the world. It offers a unique combination of weak estrogenic and potent
antiestrogenic properties. Due to this subtle mix of estrogenic and antiestorgenic
action it inhibits the fertilized ovum from nidation and thus prevents pregnancy, but
at the same time it does not appear to disturb the other estrogen effects.
Use of Centchroman as a contraceptive has been extensively evaluated in more
than 2000 women of the reproductive age groups who wanted to space their
children. Intensive monitoring by clinical examination, haematology and
biochemical tests as well as laparascopy and ultrasonographic examinations of
ovaries and uterus have shown the drug to be quite safe. Centchroman does not
cause nausea, vomiting, dizziness and break through bleeding and has no adverse
effect on lipid profile and platelet function as is seen with steroidal contraceptives.
Babies born to use failure cases have shown normal milestones. The contraceptive
effect is readily reversible and subsequent pregnancy and its outcome is normal. It
scores over steroidal contraceptive pills because it does not disturb the endocrine
system and the normal ovulatory cycle is maintained.
Centchroman has been licensed to two companies in India.
Hindustan Latex Ltd., Trivandrum, which is marketing it under the trade name,
Saheli.
Torrent Pharmaceuticals Ltd, Ahmedabad, which marketed it under the trade
name, Centron.
Centchroman as an antibreast cancer agent
Centchroman has also been found effective as an anti-breast cancer agent.
Multicentric trials in stage III/IV breast cancer patients, who were not responsive to
other modalities of therapy, were found to respond to Centchroman with an overall
responsive rate of about 56%. The data is being compiled for seeking marketing
permission from DCG(I).
been felt ever since the sixties. Clearer understanding of the role of
estrogen-progesterone balance in the development of fertilized ovum and the
priming of the uterus for implantation served as the basis for developing an agent
that would prevent pregnancy by interfering with implantation but without disturbing
the hypothalamus-pituitary-ovarian axis. Researchers the world over have been
designing and synthesising non-steroidal estrogen antagonists that would act by
disturbing the delicate balance between estrogen and progesterone at the uterine
level without interfering with their synthesis or blood levels. Centchroman developed
by CDRI precisely does this.
Centchroman is a novel non-steroidal agent unrelated to any conventionally used
contraceptive. This is the only anti-implantation agent approved for clinical use in
the world. It offers a unique combination of weak estrogenic and potent
antiestrogenic properties. Due to this subtle mix of estrogenic and antiestorgenic
action it inhibits the fertilized ovum from nidation and thus prevents pregnancy, but
at the same time it does not appear to disturb the other estrogen effects.
Use of Centchroman as a contraceptive has been extensively evaluated in more
than 2000 women of the reproductive age groups who wanted to space their
children. Intensive monitoring by clinical examination, haematology and
biochemical tests as well as laparascopy and ultrasonographic examinations of
ovaries and uterus have shown the drug to be quite safe. Centchroman does not
cause nausea, vomiting, dizziness and break through bleeding and has no adverse
effect on lipid profile and platelet function as is seen with steroidal contraceptives.
Babies born to use failure cases have shown normal milestones. The contraceptive
effect is readily reversible and subsequent pregnancy and its outcome is normal. It
scores over steroidal contraceptive pills because it does not disturb the endocrine
system and the normal ovulatory cycle is maintained.
Centchroman has been licensed to two companies in India.
Hindustan Latex Ltd., Trivandrum, which is marketing it under the trade name,
Saheli.
Torrent Pharmaceuticals Ltd, Ahmedabad, which marketed it under the trade
name, Centron.
Centchroman as an antibreast cancer agent
Centchroman has also been found effective as an anti-breast cancer agent.
Multicentric trials in stage III/IV breast cancer patients, who were not responsive to
other modalities of therapy, were found to respond to Centchroman with an overall
responsive rate of about 56%. The data is being compiled for seeking marketing
permission from DCG(I).
newgirl-chargeback
New member
MS -- I thought your story posted above was disturbing but not at all uncommon. And the simple fact that docs REFUSE to learn anything about prevententive medicine in my mind is more than inexcusable -- it is down right irresponsible.
I hope your friend either searched for a doctor who was more open-minded OR, was able to get enough information so she could arm herself with a plan....sounds like your first course of advise was a step in the right direction for her.
And, she waited four months for an appointment where her concerns were nearly rebuffed. Gotta love it.
I hope your friend either searched for a doctor who was more open-minded OR, was able to get enough information so she could arm herself with a plan....sounds like your first course of advise was a step in the right direction for her.
And, she waited four months for an appointment where her concerns were nearly rebuffed. Gotta love it.
Ceebs
New member
MS said:
Oh, THAT pill! I was intrigued when I read about it on this board a few months ago. I'll bump the thread...
I've been using the sympto-thermal method to track my ovulation, but I certainly wouldn't mind getting my hands on some ormeloxifene just to be on the safe side. I don't understand why the most invasive, potentially carcinogenic contraceptives are approved by the FDA here, but not ormeloxifene. Grr.
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