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Molecular Nutrition - compare to Impact Nutrition and Save$$
Ref No MN003
Molecular Nutrition Viratase Anti Estrogen *Intro Special
60 Cap
Price $36.95
Virataseä
Virataseä (5a-androstanedione) is the first true steroidal aromatase inhibitor ever made available as a sports supplement. This compound is a prohormone to dihydrotestosterone similar to 3-Alphaä, however it is much less active at converting to this androgen in comparison. As a prohormone it is essentially very weak, offering little value as an androgenic agent. It is more useful however for its strong intrinsic activity as an aromatase enzyme inhibitor, a trait that makes Viratase a powerfully effective anti-estrogen. Steroid using athletes however have been using a similar product for years, namely the synthetic oral androgen Proviron (mesterolone). This steroid is an oral derivative of dihydrotestosterone, differing from DHT only by the addition of the same 1-methyl group used to make Primobolan orally active. Although a potent androgen, mesterolone is most often used by athletes specifically for its abilities as an aromatase inhibitor. Viratase is very similar in structure and function to mesterolone in this regard, and as a natural supplement represents a great advance in the realm of legal anti-estrogens. It in fact promises to be far more effective than all preceding estrogen maintenance supplements.
…the first true steroidal aromatase inhibitor made available as a sports supplement.
An Intrinsic Aromatase Inhibitor
Viratase is a potent inhibitor of the aromatase enzyme complex. Its mode of action is primarily competitive, meaning that it competes with other substrates for the active binding site on the enzyme responsible for androgen to estrogen conversion. Viratase binds with aromatase but is not capable of being converted to estrogen by it, as it lacks a necessary C4-5 double bond. By temporarily preventing other active substrates from interacting with this enzyme, an anti-estrogenic effect is achieved. The ability of Viratase to inhibit aromatase is further intrinsic, meaning that it is an inherent trait of this compound. It needs not be converted to another steroid before exerting its powerful anti-estrogenic activity, as in its initial state Viratase is already the most potent natural aromatase inhibitor known.
The Most Potent Natural Anti-Estrogen
Numerous studies show the unmatched potency of Viratase as an inhibitor of the aromatase enzyme, exceeding all other natural androgens including dihydrotestosterone, androsterone and both androstanediols in this regard [ii] [iii] [iv] [v] [vi]. In some cases it was even demonstrated to be close to or even greater in potency than many prescription agents. For example, figure 1 illustrates the results of an in-vitro study evaluating the aromatase inhibiting effects of Viratase along side other natural and synthetic inhibitors including aminoglutethimide, formestane, danazol and several natural 5-alpha reduced androgens. In this study androstenedione (actively aromatized) was added to a series of breast cancer cells that were each preincubated with one of the potential inhibitors. The amount of estradiol produced after further incubation was measured, and compared to a set of control cells (androstenedione without inhibitor). Here the potency of Viratase as an aromatase inhibitor was only surpassed by formestane, a synthetic steroidal pharmaceutical suicide aromatase inhibitor derived from androstenedione. The level of activity demonstrated by Viratase was very close to formestane however (98% inhibition compared to 99%), and surprisingly exceeded the other synthetic agents of the study Danazol and aminoglutethimide.
Figure 1. In vitro inhibition of androstenedione to estrone conversion in cultured human breast carcinoma cells by aminoglutethimide, Danazol, 5a-androstanedione (Viratase) and formestane. From Perel, Danilescu, Kharlip and Blackstein. J Steroid Biochem 29 (1988) 393-99.
Need for Estrogen Maintenance
Estrogen has both positive and negative effects that you should be aware of. On the positive it supports “good” high density cholesterol, enhances growth hormone output, increase muscle glucose utilization for tissue growth and repair and even increases androgen receptor concentrations in various tissues. It is now understood that estrogen serves a useful purpose in men, particularly if we are looking for rapid muscle mass gain. If bulk is the goal it is therefore usually advised to hold off on estrogen maintenance compounds until there is a clear need for them. This brings us to the negative side of estrogen, namely that it can work to hide muscle definition by increasing water retention and fat buildup. It can also promote gynecomastia or the development of female breast tissue in men if levels get too high. Since androgens and estrogens playing opposing roles on the disposition of body fat and the growth of mammary tissue, maximizing the ratio between these two hormones is often an important objective, particularly at times when dieting and cutting are key goals or gynecomastia is a worry because strongly aromatized hormones such as testosterone are being supplemented. The now adopted practice of using mesterolone as an anti-estrogen is a clear testament to the usefulness of a steroidal aromatase inhibitor, a type of product that is available for the first time as a legal nutritional supplement.
…maximizing the ratio of [androgens to estrogens] is often an important objective, particularly at times when dieting and cutting are key goals or gynecomastia is a worry…
A Naturally Occurring Hormone
Viratase (5-alpha androstane-3,17-dione) is an androgen metabolite found in humans. It is similarly a naturally occurring compound, which can legally be sold as a nutritional supplement.
How Supplied
50mg 5alpha-androstanedione per capsule, 90 capsules per bottle. Recommended dosage is 1-2 capsules, 2 to 3 times daily.
References:
--------------------------------------------------------------------------------
Action of endogenous steroid inhibitors of brain aromatase relative to fasrozole. Wozniak and Hutchinson. J. Steroid Biochem 44 (1993) 641-5
[ii] The intracellular Control of Aromatase Activity by 5alpha reduced androgens in human breast carcinoma cells in culture. Perel, Stolee et al. J Clin Endocrinol Metab 58 (1984) 467-91
[iii] A mechanism for the suppression of estrogen production in polycystic ovary syndrome. Sanjay, Agarwal, Howard et al. J Clin Endocrinol Metab 81 (1996) 3686-91
[iv] Regulation of sex specific formation of estrogen in brain development: Endogenous inhibitors of aromatase. Hutchinson, Wozniak, Beyer and Hutchinson. J Steroid Biochem Mol Biol 56 (1996) 201-7
[v] Sex differences in the regulation of embryonic brain aromatase. Hutchinson, Wozniak, Beyer and Hutchinson. J Steroid Biochem Mol Biol 61 (1997) 315-22
[vi] Alterations in granulosa cell aromatase activity accompanying preovulatory follicular development in the rat ovary with evidence that 5a-reduced c19 steroids inhibit the aromatase reaction in vitro. Hiller, Agnes, Boogaard et al. J Endocrinol 84 (1980) 409-19
Molecular Nutrition - compare to Impact Nutrition and Save$$
Ref No MN003
Molecular Nutrition Viratase Anti Estrogen *Intro Special
60 Cap
Price $36.95
Virataseä
Virataseä (5a-androstanedione) is the first true steroidal aromatase inhibitor ever made available as a sports supplement. This compound is a prohormone to dihydrotestosterone similar to 3-Alphaä, however it is much less active at converting to this androgen in comparison. As a prohormone it is essentially very weak, offering little value as an androgenic agent. It is more useful however for its strong intrinsic activity as an aromatase enzyme inhibitor, a trait that makes Viratase a powerfully effective anti-estrogen. Steroid using athletes however have been using a similar product for years, namely the synthetic oral androgen Proviron (mesterolone). This steroid is an oral derivative of dihydrotestosterone, differing from DHT only by the addition of the same 1-methyl group used to make Primobolan orally active. Although a potent androgen, mesterolone is most often used by athletes specifically for its abilities as an aromatase inhibitor. Viratase is very similar in structure and function to mesterolone in this regard, and as a natural supplement represents a great advance in the realm of legal anti-estrogens. It in fact promises to be far more effective than all preceding estrogen maintenance supplements.
…the first true steroidal aromatase inhibitor made available as a sports supplement.
An Intrinsic Aromatase Inhibitor
Viratase is a potent inhibitor of the aromatase enzyme complex. Its mode of action is primarily competitive, meaning that it competes with other substrates for the active binding site on the enzyme responsible for androgen to estrogen conversion. Viratase binds with aromatase but is not capable of being converted to estrogen by it, as it lacks a necessary C4-5 double bond. By temporarily preventing other active substrates from interacting with this enzyme, an anti-estrogenic effect is achieved. The ability of Viratase to inhibit aromatase is further intrinsic, meaning that it is an inherent trait of this compound. It needs not be converted to another steroid before exerting its powerful anti-estrogenic activity, as in its initial state Viratase is already the most potent natural aromatase inhibitor known.
The Most Potent Natural Anti-Estrogen
Numerous studies show the unmatched potency of Viratase as an inhibitor of the aromatase enzyme, exceeding all other natural androgens including dihydrotestosterone, androsterone and both androstanediols in this regard [ii] [iii] [iv] [v] [vi]. In some cases it was even demonstrated to be close to or even greater in potency than many prescription agents. For example, figure 1 illustrates the results of an in-vitro study evaluating the aromatase inhibiting effects of Viratase along side other natural and synthetic inhibitors including aminoglutethimide, formestane, danazol and several natural 5-alpha reduced androgens. In this study androstenedione (actively aromatized) was added to a series of breast cancer cells that were each preincubated with one of the potential inhibitors. The amount of estradiol produced after further incubation was measured, and compared to a set of control cells (androstenedione without inhibitor). Here the potency of Viratase as an aromatase inhibitor was only surpassed by formestane, a synthetic steroidal pharmaceutical suicide aromatase inhibitor derived from androstenedione. The level of activity demonstrated by Viratase was very close to formestane however (98% inhibition compared to 99%), and surprisingly exceeded the other synthetic agents of the study Danazol and aminoglutethimide.
Figure 1. In vitro inhibition of androstenedione to estrone conversion in cultured human breast carcinoma cells by aminoglutethimide, Danazol, 5a-androstanedione (Viratase) and formestane. From Perel, Danilescu, Kharlip and Blackstein. J Steroid Biochem 29 (1988) 393-99.
Need for Estrogen Maintenance
Estrogen has both positive and negative effects that you should be aware of. On the positive it supports “good” high density cholesterol, enhances growth hormone output, increase muscle glucose utilization for tissue growth and repair and even increases androgen receptor concentrations in various tissues. It is now understood that estrogen serves a useful purpose in men, particularly if we are looking for rapid muscle mass gain. If bulk is the goal it is therefore usually advised to hold off on estrogen maintenance compounds until there is a clear need for them. This brings us to the negative side of estrogen, namely that it can work to hide muscle definition by increasing water retention and fat buildup. It can also promote gynecomastia or the development of female breast tissue in men if levels get too high. Since androgens and estrogens playing opposing roles on the disposition of body fat and the growth of mammary tissue, maximizing the ratio between these two hormones is often an important objective, particularly at times when dieting and cutting are key goals or gynecomastia is a worry because strongly aromatized hormones such as testosterone are being supplemented. The now adopted practice of using mesterolone as an anti-estrogen is a clear testament to the usefulness of a steroidal aromatase inhibitor, a type of product that is available for the first time as a legal nutritional supplement.
…maximizing the ratio of [androgens to estrogens] is often an important objective, particularly at times when dieting and cutting are key goals or gynecomastia is a worry…
A Naturally Occurring Hormone
Viratase (5-alpha androstane-3,17-dione) is an androgen metabolite found in humans. It is similarly a naturally occurring compound, which can legally be sold as a nutritional supplement.
How Supplied
50mg 5alpha-androstanedione per capsule, 90 capsules per bottle. Recommended dosage is 1-2 capsules, 2 to 3 times daily.
References:
--------------------------------------------------------------------------------
Action of endogenous steroid inhibitors of brain aromatase relative to fasrozole. Wozniak and Hutchinson. J. Steroid Biochem 44 (1993) 641-5
[ii] The intracellular Control of Aromatase Activity by 5alpha reduced androgens in human breast carcinoma cells in culture. Perel, Stolee et al. J Clin Endocrinol Metab 58 (1984) 467-91
[iii] A mechanism for the suppression of estrogen production in polycystic ovary syndrome. Sanjay, Agarwal, Howard et al. J Clin Endocrinol Metab 81 (1996) 3686-91
[iv] Regulation of sex specific formation of estrogen in brain development: Endogenous inhibitors of aromatase. Hutchinson, Wozniak, Beyer and Hutchinson. J Steroid Biochem Mol Biol 56 (1996) 201-7
[v] Sex differences in the regulation of embryonic brain aromatase. Hutchinson, Wozniak, Beyer and Hutchinson. J Steroid Biochem Mol Biol 61 (1997) 315-22
[vi] Alterations in granulosa cell aromatase activity accompanying preovulatory follicular development in the rat ovary with evidence that 5a-reduced c19 steroids inhibit the aromatase reaction in vitro. Hiller, Agnes, Boogaard et al. J Endocrinol 84 (1980) 409-19
