That's hardly a few reasons Nelson. In fact it's not even one when you consider Nolva does increase serum Test levels as shown in a lot of studies. Actually any anti-e be it an AI or SERM should have somewhat of a positive impact on test levels due to the estrogen inhibition/supression.
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I HAVE TO TAKE EACH STUDY IN PART TO SHOW HOW IT DOESN'T PROVE A THING. STICK WITH ME,.
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Stimulation of calcitonin secretory capacity by increased serum levels of testosterone in men treated with tamoxifen
ABSTRACT
Previous studies have suggested that sex steroids, including both oestrogen and testosterone, influence calcitonin secretion. However, a negative effect of gonadotrophins on calcitonin has not been excluded. Twelve men with infertility and low-normal serum levels of testosterone were studied before and during tamoxifen therapy.
Increases in the serum levels of LH, FSH, testosterone and calcitonin were observed after treatment. Our findings suggest that testosterone has a direct influence on calcitonin secretion.
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ALL THIS REALLY SAYS IS THAT INFERTILE MEN SHOWED IMPROVEMENT IN CALCITONIN SECRETION WHICH MAY HAVE SOME EFFECT ON TREATING INFERTILITY. THAT REALLY HAS NOTHING TO DO WITH RECOVERING FROM STEROIDS.
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Improvement in semen quality in infertile males after treatment with tamoxifen.
Lewis-Jones DI, Lynch RV, Machin DC, Desmond AD.
Department of Human Anatomy, University of Liverpool, U.K.
The effect of the anti-oestrogen Tamoxifen on the seminal quality of 131 men was studied. Parameters studied before and after treatment were sperm density, total ejaculate count, percentage progressive motility, progressively motile ejaculate count, percentage total motility and total motile ejaculate count. In a group of 38 males, the effect on serum LH, FSH, testosterone, oestradiol and prolactin was also studied. Tamoxifen significantly improved (p less than 0.05) the progressive motility in all patient groups where there was reduced pretreatment motility. Sperm density was also significantly improved in oligozoospermic patients.
Elevations in the basal serum levels of FSH was noted, even in those patients where the basal level was elevated before treatment. Increases were also observed in the serum levels of the four other hormones studied.
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ANOTHER POORLY EXECUTED STUDY. IT SAYS THINGS "WERE NOTED" BUT IT DOESN'T CLARITY. THE ONLY IMPROVEMENT WAS ON OLIGOOSPERMIC PATIENTS AND DOESN'T SAY HOW MUCH OF AN IMPROVEMENT WAS NOTED. CURIOUSLY, IT MENTIONS AN INCREASE IN "SPERM DENSITY" BUT I'M NOT SURE WHAT THAT MEANS. SOME PEOPLE CLAIM BIG LOADS ON THE STUFF WHEREAS OTHERS, SUCH AS MYSELF, DRY UP. THAT'S DEPENDENT ON A LOT OF THINGS. FOR NOW, LET'S SAY THIS JUST VALIDATES THAT NOLVA AND CLOMID ARE "CRAP-SHOOTS" AS I'VE SAID MANY TIMES.
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Clomiphene or tamoxifen for idiopathic oligo/asthenospermia.
Vandekerckhove P, Lilford R, Vail A, Hughes E.
St Mary's Hospital, IOW Healthcare NHS Trust, Parkhurst Road, Newport, Isle of Wight, UK PO30 5TG.
[email protected]
BACKGROUND: Oligo-astheno-teratospermia (sperm of low concentration, reduced motility and increased abnormal morphology) of unknown cause is common and the need for treatment is felt by patients and doctors alike. As a result, a variety of empirical, non-specific treatments have been used in an attempt to improve semen characteristics and fertility.The administration of anti-oestrogens is a common treatment because anti oestrogens interfere with the normal negative feedback of sex steroids at hypothalamic and pituitary levels in order to increase endogenous gonadotropin-releasing hormone secretion from the hypothalamus and FSH and LH secretion directly from the pituitary. In turn, FSH and LH stimulate Leydig cells in the testes, and this has been claimed to lead to increased local testosterone production, thereby boosting spermatogenesis with a possible improvement in fertility. There may also be a direct effect of anti-oestrogens on testicular spermatogenesis or steroidogenesis. This review considers the available evidence of the effect of both Clomiphene citrate and tamoxifen, both of which have a predominant anti-oestrogenic effect, for idiopathic oligo and/or asthenospermia. OBJECTIVES: The objective was to assess the effects of treating subfertile men with anti-oestrogens (clomiphene or tamoxifen) on pregnancy rates among couples where subfertility has been attributed to idiopathic oligo- and/or asthenospermia. SEARCH STRATEGY: The Cochrane Subfertility Review Group specialised register of controlled trials was searched". SELECTION CRITERIA: Randomised trials of anti-oestrogen therapy for 3 months or more compared to placebo or no placebo for subfertile males among couples where subfertility is attributed to male factor. DATA COLLECTION AND ANALYSIS: Data were extracted independently by two reviewers. Any differences were resolved with a third reviewer. MAIN RESULTS: Ten studies involving 738 men were included. Five of the trials did not specify method of randomisation.
Anti-oestrogens had a positive effect on endocrinal outcomes, such as serum testosterone levels. In trials with secure randomisation there was no difference in the pregnancy rate between the anti-oestrogen groups and the control groups (odds ratio 1.26, 95% confidence interval 0.99 to 1.56). The overall pregnancy rate for these five trials was 15.4% compared to the spontaneous rate of 12.5% in the control groups. These odds increased to 1.56 (95% confidence interval 0.99 to 2.19) when all 10 trials were included, but this result is likely to be artificially inflated. AUTHORS' CONCLUSIONS: Anti-oestrogens appear to have a beneficial effect on endocrinal outcomes, but there is not enough evidence to evaluate the use of anti-oestrogens for increasing the fertility of males with idiopathic oligo-asthenospermia.
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DID YOU READ THIS ONE? IT ESSENTIALLY SAID THERE NOT MUCH OF DIFFERENCE. THE "AUTHOR" "CONCLUDES" THERE WAS SOME IMPROVEMENT IN SOME CASES BUT THAT COULD OCCUR OVER TIME ANYWAY.
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Hormonal effects of an antiestrogen, tamoxifen, in normal and oligospermic men.
Vermeulen A, Comhaire F.
The administration of tamoxifen, 20 mg/day for 10 days, to normal males produced a moderate increase in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels, comparable to the effect of 150 mg of clomiphene citrate (Clomid). However, whereas Clomid produced a decrease in the LH response to LH-releasing hormone (LHRH), no such effect was seen after the administration of tamoxifen. In fact, prolonged treatment (6 weeks) with tamoxifen significantly increased the LH response to LHRL.
Treatment of patients with "idiopathic" oligospermia for 6 to 9 months resulted in a significant increase in gonadotropin, testosterone, and estradiol levels. A significant increase in sperm density was observed only in subjects with oligospermia below 20 X 10(6)/ml and normal basal FSH levels. When basal FSH levels were increased or oligospermia was moderate (greater than 20 X 10(6)/ml); no effect on sperm density was seen. As sperm density increased, FSH levels decreased, suggesting an inhibin effect. Sperm motility was not improved by tamoxifen treatment. In five boys with delayed puberty, tamoxifen treatment appeared to activate the pituitary-gonadal axis and pubertal development.
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THIS ONE SAYS THERE WAS A "MODERATE" INCREASE IN HORMONES (THOUGH UNSTATED) AND THAT CLOMID ACTUALLY DECREASED LH. IT ALSO CLAIMS THE FFECTS TOOK PLACE AFTER 6-9 MONTHS. WHO DOES PCT FOR THAT LONG?
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Effect of lower versus higher doses of tamoxifen on pituitary-gonadal function and sperm indices in oligozoospermic men.
Dony JM, Smals AG, Rolland R, Fauser BC, Thomas CM.
Administration of the antiestrogen tamoxifen for one month to 12 patients with idiopathic oligozoospermia significantly increased the mean basal testosterone (T) level and the responses of luteinizing hormone (LH) and follicle stimulating hormone (FSH) to constant luteinizing hormone releasing hormone (LHRH) infusion but did not significantly influence the mean oestradiol (E2) levels or the E2 over testosterone ratio.
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Mean sperm concentration and total sperm output increased by about 70% after a mean treatment period of 5.5 +/- 0.4 months. No statistically significant difference was found between the two subgroups of patients treated with either the lower (5 or 10 mg once daily) or higher dose of tamoxifen (10 mg twice daily) with respect to basal or LHRH stimulated gonadotropin and testosterone response or the E2/T ratio and the effect on sperm density and total sperm output. In both subgroups the sperm motility and morphology remained unchanged. In conclusion higher doses of tamoxifen in this study prove not to be superior to lower doses in improving mean sperm density and total sperm output. The relative small percentage of patients achieving normalisation of only these sperm parameters pleads for further search for more effective selection of patients and other more effective treatment modalities in patients with idiopathic oligozoospermia.
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this seems to suggest there isn;t much difference between those who were treated and that dosage didn't matter. And again, variables occurred after 5 months. The supps and arimidex will raise FREE T in 5 hours!
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Selection of oligozoospermic men for tamoxifen treatment by an antiestrogen test.
Schill WB, Schillinger R.
In a retrospective study 46 men with idiopathic normogonadotropic oligozoospermia were treated by 20 mg Tamoxifen daily for a period of 6 months. A significant improvement of sperm count, total sperm output, total and progressive motility as well as sperm morphology was observed. In 25 men before initiation of treatment a short-term antiestrogen test with daily 40 mg Tamoxifen for a period of one week was performed with assessment of serum levels of testosterone, LH and FSH before and afterwards. Considering hormonal response in those patients who showed a more than 50% increase of sperm count (responders), FSH levels after Tamoxifen administration were unaffected. In contrast, a significant increase of the FSH level was observed in the group of the non-responders.
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THIS IS INTERESTING. IN SOME, FSH WENT UP BUT NOTHING ELSE. YET IN THOSE WHO EXPERIENCED A HIGHER SPERM COUNT, FSH WAS UNAFFECTED. SPERM COUNT ISN;T TESTOSTERONE. AND IT ALSO TOOK 6 MONTHS.
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Serum testosterone and LH levels increased in both groups, but showed no obvious differences.
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NO OBVIOUS DIFFERENCE AFTER 6 MONTHS. THERE YOU HAVE IT.
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A similar hormonal pattern was found in father's and nonfather's concerning the response of FSH after Tamoxifen administration. It is concluded that the response of FSH towards Tamoxifen may be of use to predict improvement of semen parameters and therefore seems to be suitable to select patients for Tamoxifen therapy.
Increased sperm count in 25 cases of idiopathic normogonadotropic oligospermia following treatment with tamoxifen.
Buvat J, Ardaens K, Lemaire A, Gauthier A, Gasnault JP, Buvat-Herbaut M.
Twenty-five subfertile men, all presenting with idiopathic normogonadotropic oligospermia, were treated with tamoxifen (20 mg/day) for 4 to 12 months. Semen analysis was performed twice before treatment and at least twice after 3 to 12 months of treatment. In 14 patients, serum luteinizing hormone (LH), serum follicle-stimulating hormone (FSH), and plasma testosterone (T) were assayed before treatment, then again after 2 weeks and 12 weeks of treatment. Semen volume, sperm motility, and sperm morphologic characteristics were not modified by tamoxifen. Conversely, a twofold increase of both the mean sperm concentration and the mean total sperm count per ejaculate was observed during treatment (P less than 0.001).
Mean values of T, LH, and FSH increased during treatment, but the difference was only significant for T (P less than 0.001) and FSH (P less than 0.05). Ten pregnancies (40% of cases) were reported during the 161 months of treatment.
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VERY UNCLEAR. WHAT WERE THE NUMBERS? I HAVE TO DOUBT STUDIES THAT USE TERMS LIKE " INCREASED SIGNIFICANTLY" AS A SCIENTIFIC ASSESSMENT. THEN AGAIN, WHO ARE THESE PEOPLE?
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