3rd Generation Anti-E's

[NORMA-MAN]

Letrozole, from what I have found so far, does not seem to affect cholestrol.

Nice one bro!
If you read more about that and can give a definite positive answer, that would be great news

 

[freshr1]

"Exemestane is an irreversible, steroidal aromatase inactivator"

What's that mean? Does this mean that if I use it for long enough that eventually, I won't have to worry about aromatase anymore even when not using any anti-e's?

 

[Punschkrapfen]

What's that mean? Does this mean that if I use it for long enough that eventually, I won't have to worry about aromatase anymore even when not using any anti-e's?

no. the enzyme aromatase is made in the adrenal and ovaries (http://www.wholehealthmd.com/refshelf/drugs_view/0,1524,888,00.html). Exemestane inactivates only the enzyme already made but will not affect future production of it. So if you stop taking Aromasin new aromatase enzyme will still be produced.

 

[Zyglamail]

If you read more about that and can give a definite positive answer, that would be great news

Here is a study showing the negative effects of letrozole on cholesterol.

Effect of letrozole on the lipid profile in postmenopausal women with breast cancer.

Elisaf MS, Bairaktari ET, Nicolaides C, Kakaidi B, Tzallas CS, Katsaraki A, Pavlidis NA.

Department of Internal Medicine, Medical School, University of Ioannina, GR 451 10 Ioannina, Greece. [email protected]

Hormonal therapy plays a central role in the overall treatment of breast cancer. Aromatase inhibitors can inhibit the aromatase enzyme system resulting in a reduction of oestrogens. Letrozole is a non-steroidal aromatase inhibitor that effectively blocks aromatase activity without interfering with adrenal steroid biosynthesis. The drug can significantly reduce the levels of plasma oestrogens, which remain suppressed throughout the treatment. Data are scarce concerning the influence of these drugs on serum lipid levels. In the present study, we evaluated the effects of letrozole on the serum lipid profile in postmenopausal women with breast cancer. A total of 20 patients with breast cancer were treated with letrozole, 2.5 mg once daily. After an overnight fast, serum lipid parameters (total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, apolipoproteins A1, B and E and lipoprotein (a)) were measured before treatment and at 8 and 16 weeks afterwards. A significant increase in total cholesterol (P=0.05), LDL cholesterol (P<0.01) and apolipoprotein B levels (P=0.05) in the serum, as well as in the atherogenic risk ratios total cholesterol/HDL cholesterol (P<0.005) and LDL cholesterol/HDL cholesterol (P<0.005) was noticed after letrozole treatment. We conclude that letrozole administration in postmenopausal women with breast cancer has an unfavourable effect on the serum lipid profile.

Special thanks to gethard for the legwork on this study.

 

[BIGRICH]

great post.

 

[fitwizard]

GREAT Post Zyg!
And thanks for the info on the Cholestrol levels raised by Letrozole, however, can you tell which one (Arimidex or Letrozole) raise cholestrol levels more?

With all the Test I take which by itself raises cholestrol levels, I wouldn't want to raise it too much... Maybe Arimidex is a good tradeoff?

What's the 'parallel' dose of Letrozole to 0.5mg Arimidex ?

 

[Zyglamail]

With all the Test I take which by itself raises cholestrol levels, I wouldn't want to raise it too much

I will see if I can find details on anastrozole and cholesterol.

What's the 'parallel' dose of Letrozole to 0.5mg Arimidex ?

I would estimate 1.25mg letrozole (ie half tab).

 

[beastie]

bump for another great post

BUMP

 

[NORMA-MAN]

thanks for the info bro!although it's bad....
do u think there is anything else you can take during your arimidex/femara use to help with raised cholesterol levels...?
some people proposed clomid during the cycle, but i really only like to use it post cycle...

 

[wizardnor]

thats a big post Zyg...You never cease to amaze me