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Quick Question: SARMS S4 suppressive or not?
- Thread starter aj13
- Start date
I've got some info i'll post on it. but off the top of my head, what is known is that all 4 sarms so far that are in full swing are suppressive to some degree.
But I havn't seen any human studies done to know what that degree is, or whether it's enough to matter.
taken from "the anabolics book" ch. 20 "s.a.r.m.s"
"We will have a closer look to the SARM's that nowadays are under clinical trial. Some members of the group of aryl propionamides are already on the market as anti-androgens. Based on their structures, the SARM's S1, S4, C6 and later S22 are developed. They show good anabolic activity and have only a partly androgenic effect on the prostate. They do suppress the secretion of LH and FSH. Especially C6. shows this effect, and pharmacists consider application of this compound in male contraception."
"It will not necessarily lead to problems when the body’s own production of testosterone will be down to a low level due to the application of a SARM. The SARM itself will take over the anabolic function of testosterone. When there is very little testosterone also the production of dihydrotestosterone will be low. That is an advantage because then also the androgenic effects of dihydrotestosterone will be prevented. The body does need the small quantity of estradiol, but in most cases there will be enough testosterone produced, to take care of that. "
"The perfect SARM has to fulfill all these conditions. But just as with anabolic steroids, one SARM does this in a better and different way then the other. Untill now four groups of SARM's with promising properties have been published. These four groups are mentioned in Tabel 1. All these SARM's are androgen receptor agonists with good bonding to the receptor. The SARM-androgen receptor complexes show good anabolic activities in animal tests"
S1, S4, C6 and BMS 564929 are presently under clinical trial.
Some members of the group of aryl propionamides are already on the market as anti-androgens. Based on their structures, the SARM's S1, S4, C6 and later S22 are developed. They show good anabolic activity and have only a partly androgenic effect on the prostate. They do suppress the secretion of LH and FSH. Especially C6. shows this effect, and pharmacists consider application of this compound in male contraception.
A SARM with high anabolic activity that is attractive for sportsmen and bodybuilders, still has to be found. When this will happen, the makers of designer SARM's and illegal supplements have a problem. It is not that easy to change the structure of a SARM a bit, to enhance its anabolic activity or to circumvent patents. Any minor change in its chemical structure may change an agonist into an antagonist. This last remark should be a warning for chemical sportsmen that are offered designer SARM's. They just as well may have an opposite effect.
------------------------------------
to read the write up in full, click on the link below. but be warned, it's a lot of info.........................
20. Selective Androgen Receptor Modulators (SARM's)
But I havn't seen any human studies done to know what that degree is, or whether it's enough to matter.
taken from "the anabolics book" ch. 20 "s.a.r.m.s"
"We will have a closer look to the SARM's that nowadays are under clinical trial. Some members of the group of aryl propionamides are already on the market as anti-androgens. Based on their structures, the SARM's S1, S4, C6 and later S22 are developed. They show good anabolic activity and have only a partly androgenic effect on the prostate. They do suppress the secretion of LH and FSH. Especially C6. shows this effect, and pharmacists consider application of this compound in male contraception."
"It will not necessarily lead to problems when the body’s own production of testosterone will be down to a low level due to the application of a SARM. The SARM itself will take over the anabolic function of testosterone. When there is very little testosterone also the production of dihydrotestosterone will be low. That is an advantage because then also the androgenic effects of dihydrotestosterone will be prevented. The body does need the small quantity of estradiol, but in most cases there will be enough testosterone produced, to take care of that. "
"The perfect SARM has to fulfill all these conditions. But just as with anabolic steroids, one SARM does this in a better and different way then the other. Untill now four groups of SARM's with promising properties have been published. These four groups are mentioned in Tabel 1. All these SARM's are androgen receptor agonists with good bonding to the receptor. The SARM-androgen receptor complexes show good anabolic activities in animal tests"
S1, S4, C6 and BMS 564929 are presently under clinical trial.
Some members of the group of aryl propionamides are already on the market as anti-androgens. Based on their structures, the SARM's S1, S4, C6 and later S22 are developed. They show good anabolic activity and have only a partly androgenic effect on the prostate. They do suppress the secretion of LH and FSH. Especially C6. shows this effect, and pharmacists consider application of this compound in male contraception.
A SARM with high anabolic activity that is attractive for sportsmen and bodybuilders, still has to be found. When this will happen, the makers of designer SARM's and illegal supplements have a problem. It is not that easy to change the structure of a SARM a bit, to enhance its anabolic activity or to circumvent patents. Any minor change in its chemical structure may change an agonist into an antagonist. This last remark should be a warning for chemical sportsmen that are offered designer SARM's. They just as well may have an opposite effect.
------------------------------------
to read the write up in full, click on the link below. but be warned, it's a lot of info.........................
20. Selective Androgen Receptor Modulators (SARM's)
Last edited:
d_rson
New member
I think everyone is different. It does not seem to be at all suppressive for me. Maybe over time, but it does not seem to pevent test production from coming back to almost full swing. My blood tests put me just under 600 total test 3 weeks out from a long test cycle while on 50mg sarms for 3 weeks in active recovery. I am finishing week 4 sarms 50mg and about to roll into full PCT, and I feel fantastic, balls are swolen and full, sex drive is great, etc.
truckdaddy
Banned
I did a 4 week cycle. I took ZRT saliva tests before and after.....not suppressive at all.
interesting.
truckdaddy
Banned
sarms is simply not suppressive....
ChemWiz
New member
That's false. It definitely has a suppressive effect on the HPTA.
Post up these tests of yours then
truckdaddy
Banned
saliva test from ZRT, what are you going to say when I post em?...That I photo-shopped em?...with your one post.
Get outa here.
d_rson
New member
Like I've said before, just like other products, everyone is different. I was able to come back from being suppressed after a 12 week 500mg test cycle to just under 600 total test in week 3 of active recovery WHILE on 50mg of sarms the whole time. I also just finished 5 weeks of it, and if I am suppressed, it's minimal as my sex drive is still high, my balls are big and full, etc.
Sarms may suppress one person hard, and another not at all. Just like dbol, or var, or...etc...etc...
It's not black or white.
Sarms may suppress one person hard, and another not at all. Just like dbol, or var, or...etc...etc...
It's not black or white.
i would be careful on how people say its not suppressive because the only legitemately detailed log of a sarm (run at 100mg) showed a guy claiming for a few months as he ran it something like 8 weeks or so if i recall.. and his bloodwork came out even 'higher' but then for a few months after that he shut down and had problems with his libido and so on... had to use clomid letro etc...
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