Why We should all use Exemestane

[OMEGA]

Aromasin (exemestane) is a steroid-al AI - an irreversible aromatase inhibitor ... great for controlling estrogen "during cycle" and "PCT" ...

But, what else does it do ???
Good reading....

ABSTRACT FROM JOURNAL OF CLINICAL ENDOCRONOLOGY AND METABOLISM

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose.

RESULTS :

The 25- and 50-mg doses of daily exemestane had comparable effects in suppressing circulating estrogen concentrations, with 38 ± 24% (mean ± SD; P = 0.002 vs. baseline) and 32 ± 29% (P = 0.008) decreases in estradiol concentrations, 71 ± 12% (P < 0.0001) and 74 ± 12% (P < 0.0001) decreases in estrone concentrations, and 45 ± 27% (P = 0.004) and 51 ± 20% (P = 0.02)

BUT THERE'S MORE

There was an increase in circulating testosterone concentrations after both 25 mg (60 ± 58%; P = 0.001) and 50 mg (56 ± 48%; P = 0.003) exemestane. Androstenedione concentrations were increased as well after 25 mg (32 ± 36%; P = 0.004) and 50 mg (47 ± 59%; P = 0.052) exemestane, respectively (Fig. 1Go and Table 2Go).

SHBG concentrations were decreased by 21 ± 7% (P = 0.0003) and 19 ± 39% (P = 0.18) at 25 and 50 mg exemestane, respectively.

Free testosterone concentrations were increased by 117 ± 74% (P = 0.0001) and 154 ± 95% (P < 0.0001) at both doses, due to the decrease in SHBG and the increase in total testosterone.

THE ICING ON THE CAKE !

There were no changes in circulating serum triglycerides, cholesterol, or LDL or HDL cholesterol concentrations with either dose of exemestane.

Buy Exemestane

 

[mwm5]

i have the liquid and even though it worked well....it taste like satans ass

 

[mwm5]

are you saying this for people currently on cycle or just everyday use?

 

[OMEGA]

ps I meant ON cycle not for everyday use

On for me means about 15-20 mgs per day ( any more and joints get dry)

OFF could see how a light EOD dose of 10 mgs could shift T and E ratios in favor of T for the positive

 

[rikishi]

I thought the normal recommended dose for aromasin was 12.5 mg ed? Based on the study, you can go as high as 50 mg ed without any serious sides and reap the benefits. Sounds pretty damn good to me.

 

[OMEGA]

Yep we all here tend to use 10-15 mgs ED or even EOD for on cycle purposes

The Hi Test runners use about 20 mgs aday

So yes we diverge from the doses used above because it would dry out our joints too much

 

[showcaseshowdown]

I have been taking aromasin at 10 mgs e3d. If I bump it up to eod or ed won't that hidden my gains in the gym?

 

[OMEGA]

Eod will be OK

ED maybe NO, but you will be able to tell if its too high by lack of motivation / crappy pumps etc.
and possible joint dryness

 

[rikishi]

Omega,

Should we take the dosage all at once or space it out through the day?

 

[OMEGA]

Drug half life is LONG with Exemestane so once a day or Eod is perfect ;0

 

[DJ_UFO]

Beautiful. I wonder why adex is more popular and commonly prescribed?

 

[doublebicep]

Beautiful. I wonder why adex is more popular and commonly prescribed?

My guess it is an education / knowledge issue and a price consideration.

 

[OMEGA]

My guess it is an education / knowledge issue and a price consideration.

yep

 

[Dial_tone]

Palumbo recommends anastrozole.

 

[crulexis]

So why Can't exemestane be used as Part of a PCT Instead of Clomid or Nolva? Since it brought back Free test really nicely, and didn't effect Cholesterol

 

[OMEGA]

Exemestane should be used with light Clomid and things like Sustain and Unleashed post cycle

 

[OMEGA]

//

 

[RADAR]

Great something else to take, ohhhh how many more pills will there be?????????????????





RADAR

 

[OMEGA]

lol

 

[sweed]

Great info!!

 

[SaeedK]

I always learn something new here in EF

 

[OMEGA]

 

[sopac]

Whats a good pct dose of Exemestane?

 

[needtogetaas]

O please dont forget to post the rest of the study man. You know the part where it says that is lowere the living crap out of IGF levels

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males -- Mauras et al. 88 (12): 5951 -- Journal of Clinical Endocrinology & Metabolism

read the full study guys. Exemestane is not the end all be all of AI's

Formatane is. Its the only one that has no little to no effect on IGF,lowers shbg,and at the same time lowers both estrogen and progesterone

Its a hell of a lot more easy to dose too. Use a little for on cycle and prevention with out killing gains or use a lot to kill gyno of any kind.

 

[OMEGA]

read the full study guys. Exemestane is not the end all be all of AI's

actually yes it is
an AI in excess will blunt all kinds of things.

ps
Formestane will only be legal for so long by the way

 

[OMEGA]

Whats a good pct dose of Exemestane?

15 mgs a day

 

[needtogetaas]

Whats a good pct dose of Exemestane?

o mg bwahahahahaaaa

 

[needtogetaas]

actually yes it is
an AI in excess will blunt all kinds of things.

ps
Formestane will only be legal for so long by the way

Bastards take everything that works don't they.
Of course i know its only going to be legal for so long. They take away anything that works. sucks but its the sad truth..

The even shitter part is I highly doubt any source is going to go threw the trouble and expense of putting it back on the market it a topical form which is the only form (besides injects) that works. Oral form dont work so thats the products down fall.

 

[OMEGA]

Bastards take everything that works don't they.

yes I am actually worried about even basic supps
these days.

at lease the ones that work

 

[needtogetaas]

yes I am actually worried about even basic supps
these days.

at lease the ones that work

Codex Alimentarius-The Big Evil. The plan to take Your supplements and your right. - Need To Build Muscle

we al better be. They are working under our noises daily to get rid of them. So if there is anyone who gives a damn they shoiuld read this thread^^^ then do what it says. Not a joke ether they truly are working there little fingers to the bone right now to get rid of everything. I mean even basic vitamins. Retarded consumers will go right along with it too.

The big media scare tactics they are doing with the pro hormone raids and shit like that are working out perfect for them. Scarring the reg person with there "but what about the children?" bullshit all over the place. Get off your asses people and do something

 

[ArmaniAK47]

That says irreversible aromatase inhibitor... what does that mean broskis?

Almost sounds permanent..

 

[needtogetaas]

That says irreversible aromatase inhibitor... what does that mean broskis?

Almost sounds permanent..

da which one ya talking to my friend?

 

[PuffDawg]

da which one ya talking to my friend?

I see formestane is pretty much only available in powder form everywhere . Orally it sucks. Is it easy to find for injection or can you turn the powder into injectable? Or do they make it in topical form? I'd rather have the inject myself

 

[crulexis]

Orbit Nutrition has it , topical form and it works great.. just rub it on your shoulders and done