If you have high testosterone levels after a cycle, whether from the help of fenugreek or elsewhere, would that delay recovery since the body won't yet have a need to start cranking out its own testosterone supply because it knows there are still plenty floating around?
That would be calling fenugreek a "out side source of hormone" Or "synthetic hormone" If that was the case it be e-legal already lol. Or on the fda's shit list.
Yes its good shit and yes it does a lot of things. But a Synthetic hormone its not.
Fenugreek PE (50% testofen)
Alcohol Alcohol. 2006 May-Jun;41(3):267-73. Epub 2006 Mar 30. Links
Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells.Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The protective effect of a polyphenolic extract of fenugreek seeds (FPEt) against ethanol (EtOH)-induced toxicity was investigated in human Chang liver cells. Cells were incubated with either 30 mM EtOH alone or together in the presence of seed extract for 24 h. Assays were performed in treated cells to evaluate the ability of seeds to prevent the toxic effects of EtOH. EtOH treatment suppressed the growth of Chang liver cells and induced cytotoxicity, oxygen radical formation and mitochondrial dysfunction. Reduced glutathione (GSH) concentration was decreased significantly (P < 0.05) while oxidized glutathione (GSSG) concentration was significantly elevated in EtOH-treated cells as compared with normal cells. Incubation of FPEt along with EtOH significantly increased cell viability in a dose-dependent manner, caused a reduction in lactate dehydrogenase leakage and normalized GSH/GSSG ratio. The extract dose-dependently reduced thiobarbituric acid reactive substances formation. Apoptosis was observed in EtOH-treated cells while FPEt reduced apoptosis by decreasing the accumulation of sub-G1 phase cells. The cytoprotective effects of FPEt were comparable with those of a positive control silymarin, a known hepatoprotective agent. The findings suggest that the polyphenolic compounds of fenugreek seeds can be considered cytoprotective during EtOH-induced liver damage.
PMID: 16574673 [PubMed - indexed for MEDLINE]
1: Pharmazie. 2007 Apr;62(4):299-304.Links
Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis.Kaviarasan S, Anuradha CV.
Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The present study investigates the hepatoprotective effect of fenugreek seed polyphenolic extract (FPEt) against ethanol-induced hepatic injury and apoptosis in rats. Chronic ethanol administration (6 g/kg/day x 60 days) caused liver damage that was manifested by the elevation of markers of liver dysfunction- aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and gamma-glutamyl transferase (GGT) in plasma and reduction in liver glycogen. The effects on alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied and found to be altered in the alcohol-treated group. Ethanol administration resulted in adaptive induction of the activities of cytochrome p450 (cyt-p-450) and cytochrome-b5 (cyt-b5) and reduction in cytochrome-c-reductase (cyt-c-red) and glutathione-S-tranferase (GST), a phase II enzyme. Further, ethanol reduced the viability of isolated hepatocytes (ex vivo) as assessed by the trypan blue exclusion test and increased hepatocyte apoptosis as assessed by propidium iodide staining (PI). Treatment with FPEt restored the levels of markers of liver injury and mitigated the alterations in alcohol metabolizing and detoxification enzymes and the electron transport component cytochrome-c reductase. Increased hepatocyte viability and reduced apoptotic nuclei were observed in FPEt-treated rats. These findings demonstrate that FPEt acts as a protective agent against ethanol-induced abnormalities in the liver. The effects of FPEt are comparable with those of a known hepatoprotective agent, silymarin.
PMID: 17484288 [PubMed - indexed for MEDLINE]
1: Cell Biol Toxicol. 2007 Apr 24 [Epub ahead of print] Links
Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver.Kaviarasan S, Viswanathan P, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, 608 002, India,
[email protected] This e-mail address is being protected from spambots, you need JavaScript enabled to view it .
Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.
PMID: 17453353 [PubMed - as supplied by publisher]
1: Phytother Res. 2003 Aug;17(7):737-43. Links
Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity.Thirunavukkarasu V, Anuradha CV, Viswanathan P.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
The study investigates the effect of aqueous extract of fenugreek seeds (Trigonella foenum graecum) on lipid peroxidation and antioxidant status in experimental ethanol toxicity in rats. The ability of the seed extract to prevent iron-induced lipid peroxidation in vitro was also investigated. Ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase. The levels of serum lipid hydroperoxides and thiobarbituric acid reactive substances in liver and brain were also significantly elevated. Significantly lower activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and glutathione reductase were observed in liver and brain accompanied by depletion in glutathione, ascorbic acid and alpha-tocopherol concentrations. Activity of Ca(2+) ATPase in brain was significantly lowered. Simultaneous administration of aqueous extract of fenugreek seeds with ethanol prevented the enzymatic leakage and the rise in lipid peroxidation and enhanced the antioxidant potential. The seeds exhibited appreciable antioxidant property in vitro which was comparable with that of reduced glutathione and alpha-tocopherol. Further, histopathological examination of liver and brain revealed that, aqueous extract of fenugreek seeds could offer a significant protection against ethanol toxicity. Copyright 2003 John Wiley & Sons, Ltd.
PMID: 12916070 [PubMed - indexed for MEDLINE]
healthy glucose levels and healthy sugar metabolism By assisting the pancreas in production of insulin
the active compounds 4-hydroxyisoleucine In of fenugreek is an amino acid derivative that assists the pancreas in production of insulin. Studies have shown 4-hydroxyisoleucine reduces fasting blood sugars and improves after-meal glucose tolerance significantly. 4-hydroxyisoleucine works by two separate mechanisms: It has a direct, stimulating effect on insulin production for those who wish to increase their glucose metabolism and helps to reduce glucose resistance and the uptake of glucose, thereby reducing overall blood glucose levels. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing postmeal glucose levels—with little or no increase in blood insulin concentrations— a clear indictor of improved insulin sensitivity
Several studies show that the free amino acid 4-hydroxyisoleucine plays a valuable role in insulin promotion and glucose regulation. 4-hydroxyisoleucine stimulates insulin secretion, thereby limiting the extent to which blood glucose (the glycemic index) is elevated. Elevated blood glucose after meals leads to increased production of body fat. 4 hydroxyisoleucine promotes insulin secretion and inhibits the rise of blood glucose, thus helping to reduce body fat production. 4 -hydroxyisoleucine exhibits a specific effect on the islets of Langerhans in the pancreas. These cells are directly responsible for insulin production. Most significantly, the effect of 4-hydroxyisoleucine is glucose dependent. The higher the level of blood glucose, the greater the insulin-promoting response elicited by 4 hydroxyisoleucine. Thus 4-hydroxyisoleucine exhibits a significant regulating effect, which corresponds with the insulin needs of the body at any given time. This makes this compound “adaptogenic,” responding to the particular needs of the body at any given time
On top of this testofen In a study with castrated animals this ingredient supported muscle and sexual organ growth just as much as testosterone normally would, essentially showing that it can mimic the effects of testosterone. Other research with male athletes (ages 18-35) showed that 600mg/day of Fenuside extract for 8 weeks dramatically reduced fat tissue while increasing lean muscle
Now What you need to ask your self is if testofen raises test levels then by what mechanism does it work threw?
If its raising test levels and its not a "synthetic hormone" then there must be a Naturally accruing mechanism like bosted lh production or another Natural manipulation of the hormone loop.
Anyway you slice the cake though its results are manifested threw enhancing the bodies own mechanisms not threw introducing a "synthetic" Or "out side source" of hormone. If that were the case then yes of course it would be suppressive.
Moreover yes it has been shown to mimic Testosterone by binding to the Testosterone receptor sites and creating "Testosterone like activity" But that is still not A "synthetic" Or out side source of "hormone" by any means.
Just like nolva can bind to different receptors and "act like" and even "exhibit" estrogen "like activity" yet not lower the bodies estrogen at all well doing so or even suppress estrogen production. So can other things like testofen bind to and "act like" and "exhibit" testosterone "like activity" with out having any effect on test production its self what so ever.
SO testofen/Fenugreek Is two fold. Both promoting testosterone effects at the muscle receptor site in the absence of the bodies own natural testosterone production and helping the body to start producing normal healthy testosterone levels again.
As for its effects on freeing up bound testosterone well That may have a slim measure of merit however its deff not testofen/Fenugreek strong suit. There is a few ingredients/extracts/compounds far more Superior in that aspect.
Great product and testofen/Fenugreek is some good stuff for sure.
Phyto-Testosterone
Phyto-Testosterone
Phyto-Testosterone
Phyto-Testosterone
Phyto-Testosterone
Phyto-Testosterone
Phyto-Testosterone
Phyto-Testosterone
Click the links ^^^^^^ to read more about the photo test product. I don't have all night but testofen/Fenugreek happens to only be one of the two effective ingredients in Photo-test. Maybe i will come back some other day and explain that what for you. For now just click the link for a appetizer and get yourself ready for the big meal later. Provided I got the time to cook it.
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