Epithalon

[John Juan]

***click on my signature banner to go to the website. Epithalon is located in the Research Peptides section***



Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.

AuthorsAnisimov VN, et al. Show all Journal
Biogerontology. 2003;4(4):193-202.

Affiliation
Abstract
From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline. There were 54 mice in each group. The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice. However, it slowed down the age-related switching-off of estrous function and decreased the frequency of chromosome aberrations in bone marrow cells (by 17.1%, P<0.05). It also increased by 13.3% the life span of the last 10% of the survivors (P<0.01) and by 12.3% the maximum life span in comparison with the control group. We also found that treatment with Epitalon did not influence total spontaneous tumor incidence, but inhibited the development of leukemia (6.0-fold), as compared with the control group. The data obtained suggest a geroprotector activity of Epitalon and the safety of its long-term administration in mice.

 

[Kevlor]

Reverse aging is the future....think about it, why stop aging when you can reverse it?

 

[Kevlor]

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[Elvia1023]

Reverse aging is the future....think about it, why stop aging when you can reverse it?

I want to be 18 again

 

[John Juan]

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I can definitely use this peptide. I need to reverse age my thinning hair( thank you very much masteron), remove my wrinkles, and increase my energy so I can pull some younger ass.
I'm 45 but am attracted to 30 year old women.

 

[John Juan]

[Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].

AuthorsAnisimov VN, et al. Show all Journal
Vopr Onkol. 2005;51(1):93-8. Article in Russian.

Affiliation
Abstract
Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse. Control mice were intact or exposed to injection of 0.1 ml normal saline. The body weight and temperature, food consumption, estrous function were monitored regularly. The life span and tumor incidence were evaluated as well. As age advanced, the weight increased whereas food consumption and body temperature did not change. There was no significant substrain difference in these parameters. Exposure to melatonin or epitalon also failed to influence those indices. As age advanced, the incidence of irregular estrous cycles increased both in SAMP-1 and SAMR-1, whereas the treatment with both melatonin and epitalon prevented such disturbances. SAMP-1 revealed some features of accelerated aging as compared to SAMR-1. The mean life span of the 10% of the last survivors among treated SAMP-1 was shorter than that of SAMR-1, aging rate increased and mortality doubling time decreased. There was a direct correlation between body mass of the two substrains at the age of 3 and 12 months matched by body mass increase and longer life span. Melatonin or epitalon treatment was followed by longer mean and maximum survival in the 10% of the last survivors among SAMP-1. Melatonin involved decreased aging rate and increased mortality doubling time. Malignant lymphomas predominated in SAM without any significant difference in frequency between the substrains. While melatonin failed to influence tumor incidence or term of detection in SAMP-1, neither did epitalon affect frequency. However, it was followed by longer survival in tumor-free animals. No link between melatonin or epitalon treatment, on the one hand, and carcinogenesis, on the other, was reported in SAMR-1.

 

[Kevlor]

I can definitely use this peptide. I need to reverse age my thinning hair( thank you very much masteron), remove my wrinkles, and increase my energy so I can pull some younger ass.
I'm 45 but am attracted to 30 year old women.

Hahahaha nice, yeah epithalon is the real deal.

 

[John Juan]

I found this post on another site:

The daily injection of epithalon for ten days every six months, to the elderly, namely the older members of the eminent Russian Academy of Sciences, has enabled many of them to increase their longevity. Mortality in this assembly was reduced by 30 to 50% over seven years in those who took it.

 

[John Juan]

This peptide has been studied as a means to extend one's life span.

 

[John Juan]

This impresses me so much! The mouse that was given epithalon looks like a young mouse, much younger than the one the same age who wasn't given epithalon.