Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE!

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: : : : Ok, I've finally got a cheap source for androstenedione. I am getting with George at present : : : : to bring all of you a special deal on this. I want to do a test on norandrostenedione. Whoever : : : : wants to try this for results let me know because I will order some this week as a test. I am : : : : trying hard to see if androstadienedione (gets converted into bolderone (EQ) in the body) is : : : : found anywhere in nature. If it is we will really be rocking! : : : : Keep up the fight : : : : Unique : : : What evidence if any do you have that norandrostenedione occurs in nature? : : : And what evidence do you have that norandrostenedione or androstadienedione are : : : good substrates for 17beta-hydroxysteroid dehydrogenase and will be effectively : : : converted to there respective 17 beta hydroxy derivatives in vivo? : : : : : : : : PA : : OK, Norandrostenedione occurs NATURALLY in the placenta of pregnant females--this is a well-documented : : fact. : You better have a reference to back this up. And this sounds like a very weak argument to convince the : FDA of its "natural" status. I spent hours upon hours finding all sorts of plant and animal sources that : show androstenedione is a sufficiently "natural" compound and I am still worried the FDA might not buy it. : : Androstadienedione has been found naturally in the urine of an epilectic boy but that is all I've : : been able to find. Norandro. can be brought to the market; I'm not sure about the androstadienedione. Too : : bad about the latter though as it is also a great anti-aromatase. : What reference do you have for this? : : Anyway, what evidence of them being a good : : substrate. Well, there really isn't any studies but you have to put two and two together. The hydoxylases are : : pretty nonspecific. It is well documented that androstAnedione gets converted into DHT. Also, if you look at : : the metabolism of a c-19 and its corresponding 19-nor you will see a remarkably similar metabolic fate (pharmokinetics) : : of the drug. Obviously, there are some differences such as the aromatase enzyme but in terms of the hydroxylase there : : is no reason that I can see that it won't convert in sufficient quantities the sister compounds. These compounds are just : : the beginning--there are many others that occur naturally that have efficacy! : : Keep up the fight : : Unique : : 17beta HSD is not a hydroxylase unique, it is a reversible oxidation/reduction enzyme. Don't throw around : technical terms unless you know exactly what they mean and they are relevant. : : PA

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