Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE!

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Posted by Unique on March 24, 1997 at 22:29:32:

In Reply to: Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE! posted by PA on March 24, 1997 at 09:35:12:

: : Ok, I've finally got a cheap source for androstenedione. I am getting with George at present
: : to bring all of you a special deal on this. I want to do a test on norandrostenedione. Whoever
: : wants to try this for results let me know because I will order some this week as a test. I am
: : trying hard to see if androstadienedione (gets converted into bolderone (EQ) in the body) is
: : found anywhere in nature. If it is we will really be rocking!
: : Keep up the fight
: : Unique

: What evidence if any do you have that norandrostenedione occurs in nature?
: And what evidence do you have that norandrostenedione or androstadienedione are
: good substrates for 17beta-hydroxysteroid dehydrogenase and will be effectively
: converted to there respective 17 beta hydroxy derivatives in vivo?

:
: PA

OK, Norandrostenedione occurs NATURALLY in the placenta of pregnant females--this is a well-documented
fact. Androstadienedione has been found naturally in the urine of an epilectic boy but that is all I've
been able to find. Norandro. can be brought to the market; I'm not sure about the androstadienedione. Too
bad about the latter though as it is also a great anti-aromatase. Anyway, what evidence of them being a good
substrate. Well, there really isn't any studies but you have to put two and two together. The hydoxylases are
pretty nonspecific. It is well documented that androstAnedione gets converted into DHT. Also, if you look at
the metabolism of a c-19 and its corresponding 19-nor you will see a remarkably similar metabolic fate (pharmokinetics)
of the drug. Obviously, there are some differences such as the aromatase enzyme but in terms of the hydroxylase there
is no reason that I can see that it won't convert in sufficient quantities the sister compounds. These compounds are just
the beginning--there are many others that occur naturally that have efficacy!
Keep up the fight
Unique

Follow Ups:

Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE! PA 10:54:54 3/25/97 (1)
- Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE! Unique 11:11:46 3/25/97 (0)
I know I'm making light of a serious issue here, but that bit about the epileptic boy cracked me up!! Ain't science grand? (no msg) Al 03:57:50 3/25/97 (0)
Re: ANDROSTENEDIONE, NORANDROSTENEDIONE, AND ANDROSTADIENEDIONE! Jef 02:46:41 3/25/97 (2)
- Re:That's the scary thing..... Animal 11:44:07 3/25/97 (1)
  - Re:Unique read the post above..... Animal 11:50:37 3/25/97 (0)

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: : : Ok, I've finally got a cheap source for androstenedione. I am getting with George at present : : : to bring all of you a special deal on this. I want to do a test on norandrostenedione. Whoever : : : wants to try this for results let me know because I will order some this week as a test. I am : : : trying hard to see if androstadienedione (gets converted into bolderone (EQ) in the body) is : : : found anywhere in nature. If it is we will really be rocking! : : : Keep up the fight : : : Unique : : What evidence if any do you have that norandrostenedione occurs in nature? : : And what evidence do you have that norandrostenedione or androstadienedione are : : good substrates for 17beta-hydroxysteroid dehydrogenase and will be effectively : : converted to there respective 17 beta hydroxy derivatives in vivo? : : : : : PA : OK, Norandrostenedione occurs NATURALLY in the placenta of pregnant females--this is a well-documented : fact. Androstadienedione has been found naturally in the urine of an epilectic boy but that is all I've : been able to find. Norandro. can be brought to the market; I'm not sure about the androstadienedione. Too : bad about the latter though as it is also a great anti-aromatase. Anyway, what evidence of them being a good : substrate. Well, there really isn't any studies but you have to put two and two together. The hydoxylases are : pretty nonspecific. It is well documented that androstAnedione gets converted into DHT. Also, if you look at : the metabolism of a c-19 and its corresponding 19-nor you will see a remarkably similar metabolic fate (pharmokinetics) : of the drug. Obviously, there are some differences such as the aromatase enzyme but in terms of the hydroxylase there : is no reason that I can see that it won't convert in sufficient quantities the sister compounds. These compounds are just : the beginning--there are many others that occur naturally that have efficacy! : Keep up the fight : Unique

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