Posted by Animal on March 20, 1997 at 18:28:02:
In Reply to: Re: Metformin/creatine...My OWN experiences!!! posted by w8lifter on March 20, 1997 at 17:50:26:
: I know that on paper, Metformin and creatine usage looks like you may
: get incredible gains, but from my experiences, that was not so.
: I took 500mg of Metformin with Phosphagen HP, 3 x day, plus 2 doses of HP
: without the Metformin (loading phase) and being that Metformin is a glucose
: disposal agent, I think it did the job TOO WELL...after 5 days of loading,
: then 2 weeks of maintenance with 1-2 servings of HP a day with 1 dose of Metformin,
: I only gained 2lbs, if that......now usually i gain AT LEAST 4-6lbs on the loading
: phase as well as a few more during maitenance, but this was not the case.
: I subseuently stopped Metformin, but still take creatine, but still
: have not gained.
: So I postulate that :
: 1) Metformin disposed of Glucose too well, so much that there was no uptake into the
: muscles ((even though Metformin increases Insulin sensitivity, and the uptake of glucose
: into the muscles.))
: 2) I took Metformin at the wrong time....with the Phosphagen HP, as opposed to a half hour before
: or a half hour after....which ever may work better???
: or 3) Metformin really is not all that it is cracked up to be, and only a small % of people will respond well
: to Metformin, or people with low insulin sensitivity.
:
: Any input????
: I also would like to know why I actually experienced WORSE results with the Metformin
: than without.
:
: w8lifter
I bet everybody got gas when they first started taking metformin and your stomach fet like it was going to blow?!! That's because the inhibition of the glucose uptake in the small intestine causes the sugar to be dumped into the large intestine where the bacteria take over and create gas! That's the mechanism of inhibition. The mech of insulin sensitivy works regardless of what time you take the metformin with food. The inhibition work WHEN you take the metformin. I thought it was great and I got leaner than ever, but I NEVER took met with my post workout carb/prot drink! Anarchy in the USA!