Chrysin: Proven in vitro to competitively inhibit the aromatase enzyme.

Indole-3-Carbinole: Proven to shuttle Estradiol through a more favorable estrogen hormone excretion pathway so as to minimize hormone activity and half life.

Norandrostenediol: Proven to help inhibit the conversion of Androstenedione to Estrogen. Remember, whether you're taking Androstenendione or not, your body is still making a significant amount. Therefore, the use of Norandrostenediol may be warranted regardless.

That's about all I can think of. There is also the possibility that a supplement called Di-indolin may work similarly to Indole-3-Carbinole, but the research is inconclusive at this point.

2) Soy isoflavones - they block the conversion of androstenedione to oestrone more effectively than any substance. Its like a natural Nolvadex! It also inhibit prostrate cancer cell growth, as revealed by research data done at Emory University in Atlanta, GA.

* Very little research supports chrysin as a potent anti-estrogen compound. "There is No evidence at all that this works in normal humans. You can't take something out of a petri dish and feed it to the world!", said Dr Carlon Colker, MD, CEO and Medical Director of the Peak Wellness Institute in Greenwich, CT. Even leading chrysin researcher, Dr Larry Vickery, has commented on his concern with chrysin's safety and potential hepatotoxicity. (MD, June 1998).

HEre are the facts. Ipriflavone has been proven to be an estrogen receptor sensitizing agent. According to Brian Haycock, Ipriflavone does enhance the effects of estrogen. A study published in the journal of Calcification of Tissue International has stated that Ipriflavone, like the soy flavone Genistein, has good affinity for the estrogen receptor-beta.

The only research published on Ipriflavone that is of any use to someone concerned with building muscle is patent research. The rest of the research deals with reconvalescent bedridden elderly people and postmenopausal women with osteoperosis. Remember, estrogen controls bone formation is women, and anthing that positively modulates estrogen production will also have a positive effect on osteoperosis -- hence the use of Ipriflavone as an anti-osteoperotic. But what does all this have to do with 7-methoxyisoflavone. Well, since no research has been done on this compound, we are left to assume that the methylation of the 7 carbon of Ipriflavone to yield Methoxyflavone yields the same results as seen with Ipriflavone, only more potent. As such, you have a more potent estrogen sensitizing agent. Great! Besides, doses of methoxyflavone or ipriflavone are in the gram range for effectiveness. The people behind the patent believe you need 30mg/kg to obtain a positive response. That works out to about 3 grams per day. That would cost you about $15 a day at current supplement prices. That's too much for something that has never been proven to work.

Which leads to the next point. Why use Soy isoflavones. Soy is now being blamed by endocrinologists for the decreasing sperm counts seen in men in North America (along with various air-borne phytoestrogens). SInce medical researchers have yet to isolate those isoflavones that competitively inhibit the cytoplasmic estrogen receptor from those that induce its activity, can you be sure that consuming soy is the best thing for a man? Most would think not.

i wouldn't say Ipriflavone or 7-methoxyisoflavone increase estrogen levels. No, what they have been proven to do is to "sensitize" the estrogen receptor beta to the effects of estrogen. It might be easier to understand if you picture chromium or alpha lipoic acid