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  RECEPTORS

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Author Topic:   RECEPTORS
IROC

Cool Novice

Posts: 34
From:MASS
Registered: May 2000

posted December 28, 2000 10:50 AM

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How long does it take for my receptors to get CLEAN. I have been ON for 5 months. I stopped now since i am getting NO EFFECT from the juice. I beleive its due to my receptors being FULL. SO how long another 5 months. ????


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Francis Drake

Amateur Bodybuilder

Posts: 87
From:
Registered: Apr 2000

posted December 28, 2000 11:26 AM

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DNP will clean out your receptors quickly


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Slopain

Guru

Posts: 4051
From:Yo Aunties Pad
Registered: Jan 2000

posted December 28, 2000 11:31 AM

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Well Im sure if you took off a month to 2 months and went back on you would be ready to go again, it will never be 'virgin' like the first time, so you will have to increase dosages. What did you start your 5 month cycle at and what are you ending it with (dose, products etc..) if you were on for 5 months and didn't raise the doses, especially at the end, you won't be gaining as much.

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Burnboy

Elite Bodybuilder

Posts: 788
From:ky, usa
Registered: Jul 2000

posted December 28, 2000 11:32 AM

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theres no proof that dnp will do that

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Slopain

Guru

Posts: 4051
From:Yo Aunties Pad
Registered: Jan 2000

posted December 28, 2000 11:40 AM

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Here is some interesting reading on DNP with reguards to receptors. I included some links and a quote by cockdiesl. http://www.elitefitness.com/ubb/Archives/Forum1/03-2000/002814.html http://www.elitefitness.com/ubb/Archives/Forum1/05-2000/014931.html http://www.elitefitness.com/ubb/Archives/Forum1/09-2000/028589.html

quote:
This question is as persistant as "Can I drink Winny?".
"I am told anything that increases metabolism will help get the receptors ready for another match.
Basically a AAS gets bound to a AR and stays there a bit. Anything you take to increase metabolism will make that dead AAS release from the androgen receptor faster."
This is not how steroid receptors work, they are not permanently bound to a cell structure and they don't get "clogged" with "old" drug.
Some more plausible explanations for the rebound state seen with DNP are:
1. cell volumization. DNP is a major depletor of glycogen and fat stores, so when one quits DNP, they have a supercompensation of stored energy, which illicits an anabolic state in the cell. This is the premise for the cyclical keto diets. Carb deplete then supercompensate the muscle with glycogen.
2. local cellular factors. DNP causes some cell damage, which may increase autocrine factors, such as cytokines, prostaglandins, etc. Some of these factors are known anabolic agents.
"That includes T3, Clen, ECA and possibly DNP."
If an increase in metabolism really did this, then the beta-adrenergics would improve a cycle, and we know that clen and ephedrine do not have this effect. And T3 increases metabolism, but also increases proteolytic enzymes, thus the catabolism seen with high T3 use.

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2Thick

Moderator

Posts: 5815
From:Me, To You
Registered: Jun 2000

posted December 28, 2000 11:48 AM

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Don't use DNP. The compound is highly toxic!!!

Take 5-6 months off and you will be fine.


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Andy13

Cool Novice

Posts: 19
From:
Registered: Dec 2000

posted December 28, 2000 02:20 PM

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No offense here guys, but this "clear the receptors" thing really irks me. There is no such thing as an active hormone that becomes inactive when bound to the receptor. The hormone does not undergo any kind of structural change once it has bound to the receptor making it "defective."

And speeding up the metabolism may indirectly expedite the clearance of a drug but it is not due to the drug being broken down for energy usage. Androgens are not broken down, they are just excreted. Perhaps cerain drugs act as diuretics and expedite the clearance of steroids. But androgens are not used by cells for food.

Andy


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lpw

Amateur Bodybuilder

Posts: 111
From:MA
Registered: Jul 2000

posted December 28, 2000 03:51 PM

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Andy- Regardless of whether receptor downgrade or not, prolonged exposure to AS can decrease receptors' sensitivity to AAS. I think this is what is meant by "clearing the receptors". I think the question here is What can we do to restore the sensitivity of the receptors and can we expedite the process? I think this is a good question and I'd like to hear the answer.


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Andy13

Cool Novice

Posts: 19
From:
Registered: Dec 2000

posted December 28, 2000 10:18 PM

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Can you please be a little more specific on what you mean by receptor "de-sensitization?"

All AR's are identical. They should bind to steroids always with the same affinity.

Andy


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