I found the his post in the archives,to bad it landed there!!!
Here you have only a part of it:

ITALY
Cool Novice

Posts: 47
From:Milano, Italia
Registered: Dec 2000
posted December 10, 2000 08:32 PM

Sorry I couldn't reply sooner, I was out for the week-end.
First I would like to apologise: to say that I am pissed was exagerated, it wasn't my best day!

About BIOEQUIVALENCE and BIOAVAILABILITY:
The term bioequivalence refers to the ability of a dosage form to deliver the active ingredient to its site of action.
In other words, this means that the bioequivalence shows how effective a
pharmaceutical product is by telling how good it gets absorbed and how much of
active ingredient lands in the desired place.
For example: two different products may both contain 50mg of Nandrolone Decanoate, but have a different bioequivalence (this because of a different galenic). The product with the best bioequivalence will be more effective.
Since drug concentration cannot usually be measured directly at the site of action, measurements of the drug and/or metabolite concentration will be measured in a biological fluid (like plasma, serum, blood, urine). This method of finding the bioequivalence of a product is called BIOAVAILABILITY STUDY.

The way a drug is made (galenic formulation) influences the bioequivalence.

Let me make a clear example:
How many Viagra 100mg copies (you may call them fakes) are on the market? A lot right!
Well, the wast majority of them don't work really good; so everybody assumes that they are fake and don't contain 100mg of Sildenafil Citrate (active ingredient of Viagra)...WELL IN MANY CASES YOU WOULD BE WRONG!!! 100mg of Sildenafil cost only 10 cents and there are several conpanies that
supply it quite easily. So you see, the majority of the fakes really do contain
100mg of Sildenafil, the problem is that they don't have such a high bioequivalence because they were made in a different way as the Viagra from Pfizer (have a different galenic).

You see, making Viagra (by Pfizer) is not so easy, it's not enough to have the
active ingredient and simply press it into a tablet!
The making of Pfizer's Viagra is a 7 step process needing to heat the raw
material on 4 different occasions,...
If you follow a different "recepy" you will almost surely end up with a lower
bioequivalence.

I'm sure that many manufacturers of fakes have been frustrated by this.

That is also one of the meaning of the "Exp. Date": to tell that the bioequivalence of a product is guaranteed untill that date.

Other example: paper-steroids offer a greater surface to the air (more contact to oxygen) than blistered tablets. This will cause a faster decrease of bioequivalence with time.
10mg paper-steroid and 10mg tablet-steroid may have the same bioequivalence
today, but a different one in a year!

To talk simple:
100mg Testosterone from XY Pharma may be as good as only 80mg Testosterone from XXY Pharma. So you would make a better deal buying 100mg from XXY Pharma even if the price was 10% higher than 100mg by XY Pharma!

Knowing the bioequivalence of products will help you save money and get more results from less ml/mg.

Now I'm tired, it's 2:30am here. Good night everybody, hope you make nice dreams.

So can anyone find out what the bioequivalance of Brovel labs Norandren 200 I'd like to compaire it to the bioequivalance of Denkal labs Decanandrolen 200.

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