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  It's not about mg!!! And yes I'm pissed!!!

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Author Topic:   It's not about mg!!! And yes I'm pissed!!!
ITALY

Cool Novice

Posts: 47
From:Milano, Italia
Registered: Dec 2000

posted December 09, 2000 07:37 AM

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All of you only talk about mg, ml, underdosed,...

You should finally realize that the formulation (galenic) of a product is way more important than the content of active ingredient.

Never heard of BIOEQUIVALENCE and BIOAVAILABILITY STUDY!!!!

Apperently not, otherwise you wouldn't buy many of the veterinary products and than complain they don't work so good!
Or you wouldn't wonder anymore why 200mg Deca-Durabolin worked better than 200mg of Ttokkyo Nandrolone.
Or how comes that some Finaplix kit work and some not so good.
And surely you would not just go for the cheapest version, but for the best one!


Sorry if I sound pissed, but I hate to read that you get ripped-off getting originals that have a low BIOEQUIVALENCE (and still pay a lot).


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Damian Borleone

Amateur Bodybuilder

Posts: 195
From:
Registered: Jul 2000

posted December 09, 2000 01:36 PM

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Who's saying veterinary products don't work?


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ITALY

Cool Novice

Posts: 47
From:Milano, Italia
Registered: Dec 2000

posted December 09, 2000 01:50 PM

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Never said that veterinary product don't work, just that several of them have a low bioequivalence. There are also a few human products with a low bioequivalence.

My point is that 200mg Ttokkyo nandrolone are not as effective as 200mg Deca-Durabolin (and this is just an example).

Guys should start to realize this. The galenic of a drug is extremely important and should be considered when you choose to buy a product.


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Damian Borleone

Amateur Bodybuilder

Posts: 195
From:
Registered: Jul 2000

posted December 09, 2000 01:56 PM

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What proof do have that 200mg of "ttokkyo" nandrolone is not as effective as 200mg of deca-durabolin? Everyone who uses the ttokkyo nan300 seems to think it works quite well.


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Valdez

Elite Bodybuilder

Posts: 683
From:wa
Registered: Sep 2000

posted December 09, 2000 02:08 PM

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Why are you "PISSED!" ?? vet products and
ttokkyo's products are cheaper. so why does it bother you if I choose to use a cheaper product?

I appreciate the info though.

------------------

quote:
Back to business... as usual, C'MON DORIAN!


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Anabolicum Mister

Elite Bodybuilder

Posts: 830
From:Canada
Registered: Mar 2000

posted December 09, 2000 05:50 PM

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I don't understand. 200mg of the drug nandrolone decanoate should have the same bioavailability, whether veterinary or human grade. I'm not talking about what it says on the label, but the actual amount of drug.

If I'm wrong, please enlighten me as to why.

[This message has been edited by Anabolicum Mister (edited December 09, 2000).]


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E2

Moderator

Posts: 5635
From:VALHALLA
Registered: Mar 2000

posted December 09, 2000 06:06 PM

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Well i'm wondering if he's talking about isomers or stereoisomers is what he's talking about. Although i don't know if that would work at all, i don't know if a stereoisomer would even activate the AR in any way.

For those who don't know, a steroisomer has the same chemical make up yet a different orientation in space.

I don't know if 'lower quality' products are full of steroisomers or not. Perhaps they are, and perhaps they don't activate the AR, that could be why we see different results on the same amount of drug from different companies.


If you're talking about something else, i'm interested in hearing it.

------------------


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Pharm Animal

Elite Bodybuilder

Posts: 754
From:Honolulu, HI
Registered: Aug 2000

posted December 09, 2000 06:38 PM

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yo italy....

if you know info that others don't, please don't get pissed....share it joyously and let others revel in your vast pool of knowledge....when you say you're "pissed", it makes you look like a bitter mother fucker.....don't you agree?

PA >|===|---

PS....i'm thinking along the same lines of E2....do anabolics typically have racemic mixtures of stereoisomers? i'd like to know, bro

[This message has been edited by Pharm Animal (edited December 09, 2000).]


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Anabolicum Mister

Elite Bodybuilder

Posts: 830
From:Canada
Registered: Mar 2000

posted December 09, 2000 07:03 PM

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Exactly P.A. I've heard of racemic mixtures of substances like clen, but never of anabolic steroids. As far as I know, there are no stereoisomers of anabolic steriods. If a steroid has a different geometry it is usually given a different name. At least in terms of side groups. Maybe there are isomers of the cyclopentaphenanthrene ring?

[This message has been edited by Anabolicum Mister (edited December 10, 2000).]


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panerai

Amateur Bodybuilder

Posts: 147
From:usa
Registered: Nov 2000

posted December 09, 2000 09:54 PM

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Sorry,I don't understand italian.Can you,please,stop being pissed off,and get more specific about "galenic",also BIOEQUIVALENCO and BIOAVAILABILITO?


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jakethemus

Amateur Bodybuilder

Posts: 135
From:UK
Registered: Sep 2000

posted December 10, 2000 06:46 AM

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Bump. Come on Italy tell us more.


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conan69

Moderator

Posts: 1319
From:
Registered: Feb 2000

posted December 10, 2000 08:04 AM

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BUMP
i am interested to hear this as well

------------------
Check out my HardCore Pic sitehttp://www.dell.homestead.com/conan/index.html


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100PercentCanadianBeef

Amateur Bodybuilder

Posts: 66
From:Canada
Registered: Aug 2000

posted December 10, 2000 03:53 PM

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Seriously, I think you guys flew over his head. B-)


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DocJ

Pro Bodybuilder

Posts: 445
From:
Registered: May 2000

posted December 10, 2000 05:22 PM

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I was thinking about the same subject the other day E2, after all this recent talk about vet underdosing and such.

Bump for clarification by ITALY...

------------------
"It's a good day to be alive, sir, It's a good day to be alive he said..."


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ITALY

Cool Novice

Posts: 47
From:Milano, Italia
Registered: Dec 2000

posted December 10, 2000 08:32 PM

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Sorry I couldn't reply sooner, I was out for the week-end.
First I would like to apologise: to say that I am pissed was exagerated, it wasn't my best day!

About BIOEQUIVALENCE and BIOAVAILABILITY:
The term bioequivalence refers to the ability of a dosage form to deliver the active ingredient to its site of action.
In other words, this means that the bioequivalence shows how effective a pharmaceutical product is by telling how good it gets absorbed and how much of active ingredient lands in the desired place.
For example: two different products may both contain 50mg of Nandrolone Decanoate, but have a different bioequivalence (this because of a different galenic). The product with the best bioequivalence will be more effective.
Since drug concentration cannot usually be measured directly at the site of action, measurements of the drug and/or metabolite concentration will be measured in a biological fluid (like plasma, serum, blood, urine). This method of finding the bioequivalence of a product is called BIOAVAILABILITY STUDY.

The way a drug is made (galenic formulation) influences the bioequivalence.

Let me make a clear example:
How many Viagra 100mg copies (you may call them fakes) are on the market? A lot right!
Well, the wast majority of them don't work really good; so everybody assumes that they are fake and don't contain 100mg of Sildenafil Citrate (active ingredient of Viagra)...WELL IN MANY CASES YOU WOULD BE WRONG!!!
100mg of Sildenafil cost only 10 cents and there are several conpanies that supply it quite easily. So you see, the majority of the fakes really do contain 100mg of Sildenafil, the problem is that they don't have such a high bioequivalence because they were made in a different way as the Viagra from Pfizer (have a different galenic).

You see, making Viagra (by Pfizer) is not so easy, it's not enough to have the active ingredient and simply press it into a tablet!
The making of Pfizer's Viagra is a 7 step process needing to heat the raw material on 4 different occasions,...
If you follow a different "recepy" you will almost surely end up with a lower bioequivalence.

I'm sure that many manufacturers of fakes have been frustrated by this.

That is also one of the meaning of the "Exp. Date": to tell that the bioequivalence of a product is guaranteed untill that date.

Other example: paper-steroids offer a greater surface to the air (more contact to oxygen) than blistered tablets. This will cause a faster decrease of bioequivalence with time.
10mg paper-steroid and 10mg tablet-steroid may have the same bioequivalence today, but a different one in a year!

To talk simple:
100mg Testosterone from XY Pharma may be as good as only 80mg Testosterone from XXY Pharma. So you would make a better deal buying 100mg from XXY Pharma even if the price was 10% higher than 100mg by XY Pharma!

Knowing the bioequivalence of products will help you save money and get more results from less ml/mg.

Now I'm tired, it's 2:30am here. Good night everybody, hope you make nice dreams.


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DOGGY

Amateur Bodybuilder

Posts: 171
From:pa.
Registered: Oct 1999

posted December 10, 2000 09:01 PM

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Elite friends,
Could this be the reason some powdered products don't quite feel like the packaged
products.. ? just a thought...I would like to
know more.


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sxjunky

Novice

Posts: 5
From:fairfax, Virginia, USA
Registered: Dec 2000

posted December 10, 2000 11:22 PM

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maybe it's just me, but it seems like Italy knows what he's talking about.


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DRRman

Amateur Bodybuilder

Posts: 92
From:
Registered: Sep 2000

posted December 10, 2000 11:33 PM

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Italy seems well knowledgeable of this subject. Maybe spreads some light on the subject of the powdered substances?


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DocJ

Pro Bodybuilder

Posts: 445
From:
Registered: May 2000

posted December 11, 2000 01:41 AM

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Interesting...bump for comments from Huck, Cockdzl, et al.

------------------
"It's a good day to be alive, sir, It's a good day to be alive he said..."


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ZAP911

Novice

Posts: 9
From:CA
Registered: Dec 2000

posted December 11, 2000 03:34 AM

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Hey Thonyct99 You sound like an idiot to me, not Italy.

He made the compareson between 200mg from Deca and 200mg from Ttokkyo!
Not 1ml Deca and 1ml Ttokkyo!

I think you should apologise and maybe read better next time!


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BigJay81

Guru

Posts: 3804
From:LIFT UNTIL YOU DIE!!!!!!!!!!!!!!!!!!!!!!!!!!!
Registered: Jan 2000

posted December 11, 2000 03:46 AM

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YOU ARE A <<<<<<<<<<<<<<<<PUKE<<<<<<<<<<<<<<
THONYCT99
WHO THE FUCK ARE YOU?

------------------

Lift
Until You Die!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!


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The Ghost

Pro Bodybuilder

Posts: 521
From:Earth
Registered: Nov 2000

posted December 11, 2000 08:52 AM

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I think Italy is right. You have to wonder why testosterone from Schering is so much better than test from Brovel. There has to be more to it than just simple "underdosing". Maybe that is why the pros grow so well because they have access to high grade material, and alot of what we can get is mexican vet gear. Some of us maybe spinning our wheels because we are shooting solutions that may be only 50% as effective as some of the stuff they are taking.

I don't know, just a thought.


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Steriod_Virgin

Pro Bodybuilder

Posts: 545
From:
Registered: Apr 2000

posted December 11, 2000 10:25 AM

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great read

bump


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grizz

Cool Novice

Posts: 48
From:
Registered: Jun 2000

posted December 11, 2000 01:47 PM

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Good stuff, thanks Italy and others...

------------------
It will only seem kinky the first time...

You can run but you'll just be tired when I catch you.


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E2

Moderator

Posts: 5635
From:VALHALLA
Registered: Mar 2000

posted December 11, 2000 02:09 PM

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Yes I'd have to say i agree with you Italy.

------------------


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Fish

Elite Bodybuilder

Posts: 755
From:Indianapolis, In USA
Registered: May 2000

posted December 11, 2000 02:31 PM

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Okay,
Thanks.

------------------
SIZE MATTERS MOST

"Obsession is passion. Use it. Make it your strength." -by Puc



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