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  Undecanoate Ester???

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Author Topic:   Undecanoate Ester???
RojoDiablo

Amateur Bodybuilder

Posts: 75
From:CA
Registered: Aug 2000

posted November 09, 2000 04:21 PM

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How long does this ester stay active?

I did a search and came up with a bunch of different answers...
One place said it's the same as cypionate(5-7 days)
Another said even longer than the decanoate(3 weeks+) ester in sust
And another place said it was even shorter acting than propinate(less than 1 day)

Would appreciate any info from anyone who knows how long it lasts or if you have tried the test undecanoate of the powdered variety


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Hugh Gellatts

Amateur Bodybuilder

Posts: 72
From:
Registered: Oct 2000

posted November 09, 2000 04:27 PM

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I'm gonna knock down 250mg a day in caps the week after my cycle. Should be as useless in providing gains as real Andriol, but maybe it will lessen the crash. I was hoping primo or anavar bulk powder would be available for that purpose, but guess not.


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RojoDiablo

Amateur Bodybuilder

Posts: 75
From:CA
Registered: Aug 2000

posted November 09, 2000 04:33 PM

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Not a bad idea it is pretty cheap and it's probably worth it if it will lessen the post-cycle crash.
I'm interested in how lone the ester lasts when injected( forgot to put that in orginal post). If anyone had injected the powdered Test Undecanoate, what kinda of water retention or gyno symptoms did ya get, compared to other popular test's?


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GymRatSD

Elite Bodybuilder

Posts: 905
From:San Diego, CA, USA
Registered: Jun 2000

posted November 09, 2000 04:49 PM

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Andriol = Testosterone Undecaonate.

For our purposes, it's useless. Very little of the actual testosterone actually makes it into the bloodstream -- most of it is destroyed in the digestive processes. And what makes it through the digestive system is only available for a few hours.

Andriol is a very old product in terms of steroid development. It was one of the first attempts at an oral anabolic. Why it's still on the market (not in the US) I don't know since there are much better orals available (oxandrolone, methandrostenolone, Anadrol).

If it were made into an injectible, the story would be much different. Placed in an oil solution, the duration would be quite long. The undecanoate ester is one carbon longer than the longest ester in Sustanon (decanoate), so the "half-life" (term used loosely) would be almost two weeks (very roughly).


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cockdezl

Pro Bodybuilder

Posts: 472
From:
Registered: 2000

posted November 09, 2000 05:50 PM

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Test undecanoate is not a good testosterone ester. It's half life if very long, and requires very high initial doses to give a supraphysiological blood level, somewhere in the 1000mg range. Because it has such a lipophilic ester, it tends to prefer the oil depot.

J Androl 1998 Nov-Dec;19(6):761-8

"A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men."

Zhang GY, Gu YQ, Wang XH, Cui YG, Bremner WJ

National Research Institute for Family Planning (World Health Organization Collaborating Center for Research in Human Reproduction), Beijing, People's Republic of China.

Testosterone undecanoate (TU) provides testosterone (T) replacement for hypogonadal men when administered orally but requires multiple doses per day and produces widely variable serum T levels. We investigated the pharmacokinetics of a newly available TU preparation administered by intramuscular injection to hypogonadal men. Eight patients with Klinefelter's syndrome received either 500 mg or 1,000 mg of TU by intramuscular injection; 3 months later, the other dose was given to each man (except to one, who did not receive the 1,000-mg dose). Serum levels of reproductive hormones were measured at regular intervals before and after the injections. Mean serum T levels increased significantly at the end of the first week, from less than 10 nmol/L to 47.8+/-10.1 and 54.2+/-4.8 nmol/ L for the lower and higher doses, respectively. Thereafter, serum T levels decreased progressively and reached the lower-normal limit for adult men by day 50 to 60. Pharmacokinetic analysis showed a terminal elimination half-life of 18.3+/-2.3 and 23.7+/-2.7 days and showed a mean residence time of 21.7+/-1.1 and 23.0+/-0.8 days for the lower and higher doses, respectively. The area under the serum T concentration-time curve and the T-distribution value related to serum T concentration were significantly higher following the 1,000-mg dose than following the 500-mg dose. The 500-mg dose, when given as the second injection, yielded optimal pharmacokinetics (defined as mean peak T values not exceeding the normal range and persistence of normal levels for at least 7 weeks), suggesting that repeated injections of 500 mg at 6-8-week intervals may provide optimal T replacement. The mean serum levels of estradiol were normalized following the injections, and prolactin levels were normal throughout the study. Significant decrease of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels was observed, with the decrease in LH levels being more pronounced. There were no significant differences in serum LH and FSH levels between the two doses. Sex hormone-binding globulin (SHBG) levels before any T therapy were near the upper limit of normal for adult men and were reduced by approximately 50% just prior to the second dose of TU. The decreased SHBG levels produced by the first TU injection could have led to lower peak total T levels and to a more rapid clearance of T following the second TU injection. We conclude that single-dose injections of TU to hypogonadal men can maintain serum T concentration within the normal range for at least 7 weeks without immediately apparent side effects. It is likely that this form of T would require injections only at 6-8-week or longer intervals, not at the 2-week intervals necessary with currently used T esters (enanthate and cypionate). This injectable TU preparation may provide improved substitution therapy for male hypogonadism and, in addition, may be developed as an androgen component of male contraceptives.


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