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  how many mg's per I.U.?? sorry I know this was asked a while back :o)

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Author Topic:   how many mg's per I.U.?? sorry I know this was asked a while back :o)
Motorhed

Amateur Bodybuilder

Posts: 208
From:Colorado USA
Registered: Apr 2000

posted October 31, 2000 04:49 PM

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Could not find in search. I think it was 2.7 / 1.


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8pack

Amateur Bodybuilder

Posts: 66
From:Chi-Town
Registered: Oct 2000

posted October 31, 2000 05:12 PM

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Just found this out myself. IU is a measure of the concentration substance in the liquid. So, lets say you have a 10ml vial and in that 10ml vial you have 10,000 IU's that gives you 1000 IU's per ML. got it. OK once more lets say you have a 2ML vial in that you have 30 IU's that means 15 IU's per ML.


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2Thick

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posted October 31, 2000 05:19 PM

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It is 2.6g/IU

Since it is a measure of concentration it cannot be measured in volume.


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Motorhed

Amateur Bodybuilder

Posts: 208
From:Colorado USA
Registered: Apr 2000

posted October 31, 2000 05:37 PM

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Thanks 2Thick!!!


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GymRatSD

Elite Bodybuilder

Posts: 843
From:San Diego, CA, USA
Registered: Jun 2000

posted October 31, 2000 06:05 PM

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I hate to do this, but 2Thick is wrong here.

There is no direct conversion of Interational Units (IU) to any other measurement. Interational Units is, in pharmacology, a quantity of a substance, such as a vitamin, hormone, or toxin, that produces a specified effect when tested according to an internationally accepted biological procedure. It is a generic value, not a concentration, weight, or volume. It cannot be weighed on a scale, in a beaker, or with a ruler.

This is used when a substance cannot be purified down to its dry form, or it may be biologically or chemically unstable in its dry form.

Therefore, each substance has its own conversion from IU to mg or ml, whether it's insulin, growth hormone, or Vitamin A.

[This message has been edited by GymRatSD (edited October 31, 2000).]


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2Thick

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posted October 31, 2000 06:50 PM

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When it concerns GH and insulin it is 2.6g/IU

There is nothing else an anabolic board would measure IU in. Therefore GymRatSD is correct but it just complicates things when you bring that info into this context.


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GymRatSD

Elite Bodybuilder

Posts: 843
From:San Diego, CA, USA
Registered: Jun 2000

posted October 31, 2000 06:57 PM

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That conversion is good for insulin, but NOT for GH (growth hormone). For example, the brand Humatrope by Lilly is 3 IU per mg. It's not a conversion that is all that simple.

And, to get specific, it's 2.6 mg per IU for insulin.

[This message has been edited by GymRatSD (edited October 31, 2000).]


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2Thick

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posted October 31, 2000 07:05 PM

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You are incorrect about the GH; it is 2.6mg/IU.

And you know I just forgot the m in mg....lol.


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2Thick

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posted October 31, 2000 07:08 PM

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...for 99% of GH.


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GymRatSD

Elite Bodybuilder

Posts: 843
From:San Diego, CA, USA
Registered: Jun 2000

posted October 31, 2000 07:08 PM

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You might want to look at the white paper on the Lilly brand or Humatrope. It clearly states that 5 mg = 15 IU, 6 mg = 18 IU, etc.

Here's the link: Humatrope White Paper

Also, the same information is provided for Nutropin, the hGH by Genentech. Here's the link for that one: Nutropin White Paper

Don't mean to be argumentative, but I just want to see accurate information to be read by all.

[This message has been edited by GymRatSD (edited October 31, 2000).]


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2Thick

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posted October 31, 2000 07:38 PM

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Since you want to be precise, I will show you the fine print (semantics) that proves my point.

"Each 5 mg Nutropin vial contains 5 mg (approximately 15 IU) somatropin, lyophilized with 45 mg mannitol, 1.7 mg sodium phosphates (0.4 mg sodium phosphate monobasic and 1.3 mg sodium phosphate dibasic), and 1.7 mg glycine"

As you can clearly see, it says approximately 15IU (including the other substances). Therefore they are just using a round number for simplicity's sake and not to make the dosage too complex for the patient.

I just wanted to be accurate since 2.6mg could technically be synonymous with �approximately� 3.0mg.



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GymRatSD

Elite Bodybuilder

Posts: 843
From:San Diego, CA, USA
Registered: Jun 2000

posted October 31, 2000 07:57 PM

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quote:
Originally posted by 2Thick:
When it concerns GH and insulin it is 2.6g/IU

There is nothing else an anabolic board would measure IU in. Therefore GymRatSD is correct but it just complicates things when you bring that info into this context.


This is the last of the pissing match I going to post on...

One other substance that is commonly used and quoted here on the Anabolic Board is hCG, and this has a very different IU/mg or IU/ml ratio. Therefore the blanket 2.6 IU/mg for anabolic purposes cannot be used.

And the Lilly site for Humatrope does not use the term "approximately."


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