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 Anabolic Discussion Board
 Is a nandralone a nandralone?
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| Author | Topic: Is a nandralone a nandralone? | ||
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Pro Bodybuilder 
Posts: 306 |
Reading some of the fine references available on the net, many will cite one nandralone (example undecanoate) as being more (or less) androgenic as another ester (say proprionate). Is there any basis, aside from personal experience/anecdote, for making that statement? Some esters do have shorter half-lives (like proprionate above) and some have lower proportions of active ingredient by weight depending on the ester. Really though, is there a scientific reason for saying one ester is more anabolic or androgenic when they both have the same base? Same holds true for testosterones... I'm curious. Peace! ------------------     | ||
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Pro Bodybuilder
Posts: 519 |
according to bill roberts no, an ester is an ester. he said something to the effect that as long as the drug is administered once per half life it will all be the same regardless of the ester. | ||
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Pro Bodybuilder
Posts: 425 |
In terms of the drug itself, a nandrolone is a nandrolone, no matter the ester. The receptors only recognizes the free nandrolone. In terms of the pharmacokinetics, then yes, there can be a difference in effect due to esters. Essentially, the shorter the half-life and release rate, the stronger it tends to be due to higher peak levels. Think of a graph that spikes upwards fast and high, but then drops quickly too...this would be representative of the short acting ester. Now think of a curve that slowly rises, but never reaches the same peak level of the shorter ester...this is the long acting esters. This is the problem with the undecanoates. The ester is too long and slows down the release so that the drug only reaches moderate levels, but stays there for a very long time. It would require a very high initial dose to get supraphysiological levels. | ||
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Novice 
Posts: 4 |
If what you are asking is "Will I see more androgenic side effects with one ester vs. another?", then yes, due to the reasons Cockdezl mentioned, you will. Will the inherent androgenicity of the drug change? No. Will the androgenic/anabolic ratio change? Yes and no. |
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posted October 23, 2000 06:41 PM