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 Testosterone Enanthate Release/Half Life
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| Author | Topic: Testosterone Enanthate Release/Half Life | ||
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Amateur Bodybuilder 
Posts: 109 |
From what I have researched the half-life is 7 days and the release time is approximately 10-14 days. What I do not understand is what does half-life mean? My understanding is that once the test is released it will remain active for 7 days. Therefore, if I were to inject 250 mg of testosterone enanthate would I be correct in assuming that, at 180mg of free testosterone divided by a 10 day release pattern, the following amount of test would be in my body. Day.....Mg of Test Quoted from Chemical Wizardry: �Enanthate will release a steady (yet fluctuating as all esters are) level of hormone for approximately 10-14 days.� (Chemical Wizardry) DSPO     | ||
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Amateur Bodybuilder
Posts: 109 |
Bump | ||
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Elite Bodybuilder 
Posts: 796 |
Half-life in this case is that at day seven, half of the testosterone injected has been removed from the associated ester, hence half of the injection is now free testosterone to be used by the body, the other half is still intact testosterone enanthate. Free testosterone is used rather quickly by the body -- it is not active for seven days (reasoning behind the frequent suspension injections, but that's another topic). Therefore, your chart is quite off base. | ||
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Amateur Bodybuilder
Posts: 109 |
Thanks for the clarification...now, how much free testosterone can your body utilize each day? Therefore, if the half-life is 7 days and 180 mg of test is in each injection can I assume that approximately 13 mg of free testosterone is being released into my body each day? [This message has been edited by DSPO (edited October 18, 2000).] | ||
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Elite Bodybuilder
Posts: 796 |
The first question is an intriguing one. I'd like to hear some responses to that. I don't know the answer off the top of my head. To answer the second part, in a perfect work, yes, you'd have about 18 mg of testosterone floating through your veins each day after the injection. But the fact remains that enanthate (and all esters for the sake of argument) do not release at a steady rate. | ||
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Elite Bodybuilder
Posts: 949 |
bump for gymratsd | ||
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Cool Novice 
Posts: 48 |
bump | ||
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Amateur Bodybuilder
Posts: 143 |
and who's gonna tell us the true and detailed story? bump for this person... | ||
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Cool Novice
Posts: 37 |
I don't think it is known how much free testosterone the body can utilize in each day. We do not know all the ways in which testosterone works, so how could we know how much can be used. By using every increasing dosages you do get better results (not linear results though) so the body is using more testosterone. The half-life of enanthate is four days. http://www.mesomorphosis.com/exclusive/pharmacology/vol02/991213.htm | ||
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Elite Bodybuilder
Posts: 796 |
The half-life on enanthate is not so cut-and-dry to say bluntly "four days". That is not true. In fact, half-life is very difficult to measure as there are many physiological and biochemical properties that affect the rate by which an ester is removed from the hormone. Even in the article you quoted, he states, "Testosterone cypionate has a half-life of 8 days, the enanthate ester has a half-life of 4 days, and nandrolone decanoate has a half-life of 8 days. These figures are only approximate. The difference between these values for cypionate and enanthate probably includes difference attributable to different measuring techniques. The actual difference is probably not more than two days." | ||
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Cool Novice
Posts: 37 |
You're right "GymRatSD", 4 days is not cut-and-dry, however there has been only one study ever done on enanthate to determine it's half-life. Even then, the exact half-life is not easy to determine for the reasons you said. That's why I referenced Bill Robert's article on esters instead of the medline reference. In determining when to inject to maintain a stable level, I would err on the side of caution and inject every 5 days at the outside. As the old saying goes, "you can never inject too frequently". On a side note, I discovered today that in some steroid esters, larger dosages gave longer half-lifes. Most likely has to do with the body's ability to breakdown and remove the ester. | ||
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Elite Bodybuilder
Posts: 796 |
Very true. I generally use enanthate twice a week for steady hormone levels. Seems to work for me. | ||
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Elite Bodybuilder
Posts: 737 |
The pharmacokinetics (PK) of many drugs and particularly injectable AS's are not well understood. The half-life quoted in those figures are just ballpark at best. In fact, there are many different "half-lives" relevant to i.m. injections of AS. For e.g., half-life of release from the depot (injection site), half-life of the ester in the serum (before it is cleaved), half-life of free-testosterone, etc. It has also been stated that the (enanthate) ester is active for, say, 8 days. What is being stated here is that after a single dose injection, the testosterone levels will remain above physiological levels for eight days (i.e. they will return to normal after eight days). Studies of multi-dose pharmacokinetics are rare if any. And just how high above physiological levels is optimum for muscle growth? Who knows. Also, the PK can vary depending on injection site, volume, and probably the price of tea in China. As far as how much testosterone a body can use, I imagine that is an equally tough question. Because what is important is not really how much testosterone is metabolized but how much can be used for increased protein synthesis, particularly in muscle cells. If someone has a number for this, I'd really like to see how they arrived at it. To make a long story one sentence longer, I guess what I'm saying is that I don't believe there are any solid answers to your question. | ||
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Amateur Bodybuilder
Posts: 69 |
dam my favorite subject here on half life ,,not to may people really know shit about it i was wondering that two and they told me deca if i inject 200 mg in week one and 200 mg in week 2 how many mg will be in my blood well got an most replys were deca is active for about the same of test 8 days half life is 17 days so in week one i have no idea how many but in week 2 they told me 50% off 200mg so thats 100 plus the 200 of week two that will be 300 mg in week 2 active and next time is 50% of 300 = 150 + UR next shot of waht ever is this fucking true and how come not to many ansers on this bummer,,,, |
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posted October 17, 2000 10:41 PM