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 Anabolic Discussion Board
 Stacking synergy:A small piece of the puzzle.....
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| Author | Topic: Stacking synergy:A small piece of the puzzle..... | ||
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Guru 
Posts: 2087 |
Okay,I'm going to attempt to address a piece of the puzzle towards effective combinations of compounds from a more scientific standpoint than just throwing two drugs together haphazardly so we can say we're"stacking".Keep in mind there are MANY variables here,and I'm only addressing one key(yetimportant)issue:Anabolic steroids work through more than one pathway-activating the androgen receptor(A/R)is only one of them.Some A/S are effective in certain pathways but not others.It's best to use a combination that covers both androgen receptor mediated activity and non-A/R mediated activity(outside of the A/R).Examples of drugs that do not bind well to the A/R and thus achieve their effectiveness through other pathways are:Anadrol-50,Dianabol,and winstrol.Drugs that possess strong binding affinity to the A/R and thus achieve their effects through this mechanism are as follows:Oxandrolone,equipoise,primobolan Depot,and nandrolone(deca).*Note-Testosterone exhibits powerful effects through both A/R and non-A/R pathways.This is one of the reasons that it is universally accepted as the most powerful"stand-alone"muscle builder(trenbelone also shares similar characteristics).Based on the above information,let's look at combining groups for complete growth through different pathways.Effective combinations could be(but are not limited to)--Testosterone/trenbelone + Dianabol or winstrol***Deca/equipoise + winstrol or dianabol***Primobolan/Equipoise + winstrol,d-bol or anadrol-50***Oxandrolone + winstrol or d-bol(*note-even though this would be a double AA-17 cycle,oxandrolone actually,for some odd reason exhibits very little liver toxicity,hence the the 2 together should be okay). There are many different combinations that can be played with from the above selection,just be sure to include one from each group(A/R**non-A/R activity) for maximum effectiveness.Well,as stated above,this gives only a piece of the puzzle,but hopefully it will lay a little groundwork down for some of you guys,so you can start experimenting with different compounds with a direct purpose in mind.Hope you enjoy fellas.---Huck    | ||
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Elite Bodybuilder 
Posts: 949 |
Great post. Thanks for the info.... ~Green  | ||
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Elite Bodybuilder
Posts: 765 |
A rare moment of intellectuality on the Elite board... bravo. | ||
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Guru
Posts: 2087 |
A classic example of this type of synergy exists in the age-old deca/d-bol stack.Most users years ago probably had no idea why these two compounds worked so terrifically together,they just knew that when combined,they seemed to amplify the effects of each other.This is due to the fact that deca has a potent binding affinity to the A/R,whereas dianabol is very powerful outside of the A/R,thus each one takes up the space where the others weakness left off,making for a potent one-two punch of anabolic activity.... | ||
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Elite Bodybuilder
Posts: 1054 |
bump ------------------ Don't look back, life is too short | ||
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Amateur Bodybuilder 
Posts: 103 |
Im planing for a tren/dbol cycle with some prov as the antiestrogen and to help hpta with clomid on cycle close. | ||
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Elite Bodybuilder
Posts: 903 |
Good Post Huck! That is why I am going to take dbol and test in my next cycle. ------------------ | ||
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Elite Bodybuilder
Posts: 742 |
Good post Huck. My next cycle: d-bol, test, eq ------------------ | ||
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Amateur Bodybuilder
Posts: 219 |
awesome, HUCK...you're quite the GURU who walks the walk! thanks, bro ------------------ | ||
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Pro Bodybuilder 
Posts: 410 |
we need tto make anabolic principles like the weider principles: stacking, tapering, short cycles.......... | ||
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Pro Bodybuilder
Posts: 505 |
Finally !! good info. It is true that dbol and deca is known to be one of the most effective stacks (gains/keeping gains). Non AR pathways include: * increase igf-1 production in the liver. | ||
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Guru
Posts: 2087 |
Other speculated non-A/R activities include:Gene expression independent of the A/R,activity in microsomes,activity in nerves,differentiation of Satellite cells into mature muscle cells is another point of speculation regarding non-A/r mediated mechanisms...... | ||
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Amateur Bodybuilder
Posts: 80 |
That last part,"the differenciation of satalite cells into mature muscle cells".I like the sound of that,makes it sound like A.S.use is more then just trading temporary increases in muscle for ball size. New muscle cells should be permanant right?I have read only passing references to this and would love it if anyone has a few links on this.Does having more muscle cells mean that you have expanded your natural maximum size,and could then grow larger(if only slightly)then if you had never used A.S.? | ||
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Guru
Posts: 2087 |
EXACTLY.You have basically activated cells for everyday use that were normally only called upon under the extremest of conditions.They now become part of the main frame. | ||
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Amateur Bodybuilder
Posts: 219 |
i have an old friend who has done research in satellite cells' maturation process for her master's degree ...damn i wish i still knew where she was ------------------ | ||
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Guru
Posts: 2087 |
Come on fellas,let's keep this at the top for a while,as this will help some people with putting together the correct drug choices in a stack..... | ||
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Amateur Bodybuilder
Posts: 102 |
check out an article in last months scientific american. I think that the article is entitled "muscle and Genes, are great athletes born and not made." It is an excellent article that explains how satelite cells divide and turn into new muscle cell nucleus, which is responsible for muscle growth since muscle cell nucleus cannot divide. Check it out its very informative | ||
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Amateur Bodybuilder
Posts: 293 |
Great stuff Huck...I'll bump it up! ------------------ | ||
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Cool Novice 
Posts: 16 |
Damm, what kind of smart drugs do they have in Timbuktu? | ||
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Guru
Posts: 2087 |
LOL.... | ||
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Cool Novice
Posts: 15 |
Huck, Still following your trend, what can you say about stacking test,deca and stanozolol ? You say both test and deca stack well with winstrol; what about their own interaction ? CAn you technically discuss that ? Thanx, ANdrewXON | ||
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Cool Novice
Posts: 14 |
great post life is all about synergy. | ||
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Guru
Posts: 2087 |
On a mg per mg basis,deca actually has a stronger binding affinity to the androgen receptor than test,yet test indisputedly outperforms it for gaining mass.This is most likely for two reasons:More mgs can be used with test with fewer sides(progesterone is difficult to control when high amounts of deca are incorporated)and test is effective outside of the A/R as well,whereas deca is not.I think the two together go nicely as deca may actually bind to certain A/R's that the test might not be able to.BUT,you could also make the argument that the two might be competing with each other at the A/R as well.I personally think the two together work quite well.Throw winstrol into the mix and now you have an even more aggressive non-A/R attack to compliment the other two,not to mention combating the progestogenic sides.Wonderful stack.... | ||
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Cool Novice
Posts: 15 |
Huck, you touched an issue on your last reply I would like to have more info about: I see there are some side effects related to the release of antagonist hormones when we're using AAS...You specifically cited 'progestonic side effects' and winstrol's counteractive effect. can yo unlighten me about that, and even help me with some links that would step deeper into this subject ? Peace, AndrewXON | ||
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Guru
Posts: 2087 |
Winstrol is notorious for having an aggressive binding affinity with the progesterone receptor,yet it is NOT progestogenic.Therefore it occupies the receptor in an"idle"state,protecting it from being latched on to and activated by anabolics such as deca & anadrol,who behave like progesterone on the receptor(activating it). | ||
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Cool Novice
Posts: 15 |
Ok Huck. I am starting tomorrow exactly this test/deca/winny 8 week cycle, at 500mg dura/week, 400mg deca/week and 50mg winny EOD thru whole cycle (drinking it, following your advice). Would yo consider it to be a plus to add t3 at 25mcg/day if I had it available during the cycle ? I will be posting about the results of the cycle for all in the board to comment and learn along with me. ANdrewXON | ||
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Guru
Posts: 2087 |
I would save the T-3 for a cutting cycle down the road.Your stack looks teriffic though.... | ||
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Cool Novice
Posts: 15 |
Even if I had the t3 available really, really cheap on the drugstore next to my apartment and needed no prescription (as it really is in Brazil) ? Thanks for your attention, man. AndrewXON | ||
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Amateur Bodybuilder
Posts: 107 |
Great post!!! | ||
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Guru
Posts: 2087 |
You know,the T-3 wouldn't be a bad addition from a metabolic standpoint as it will increase biosynthesis of protein as well as more effecient use of carbs,but I'll admit to being ignorant of its proper dosage to achieve this result in a bulking cycle. | ||
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Cool Novice
Posts: 15 |
Ok... Well Huck please keep posting stuff like that. I hope me and others can also give positive replies just so we can mantain high level topics and high level discussion at the board. AndrewXon | ||
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Guru
Posts: 2087 |
You bet,and good luck with your cycle buddy.... | ||
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Elite Bodybuilder
Posts: 622 |
YOU ARE D MAN HUCK. TX | ||
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Elite Bodybuilder
Posts: 903 |
Do the T3 at 25mcg in your bulking cycle... It will increase both metabolism and protein synthesis. If you are lucky enough to get the 5mcg tabs you could take only 15mcgs instead. I stick to 25mcg's! ------------------ | ||
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Guru
Posts: 2087 |
Thank you Drexx... | ||
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Cool Novice
Posts: 15 |
Drexx, we only have available in Brazil Cynomel in the 25mcg and 50mcg tabs. So I guess it'll be the 25mcg one. Peace, AndyXON | ||
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Cool Novice
Posts: 16 |
One thing I disagree on concerning stacking: EQ and D-bol is not a good stack, as they are chemical variations of each other. I'll see of I can find the posts that discussed this and I'll post 'em up. | ||
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Cool Novice
Posts: 15 |
That would be nice if we could have more info about this eq/dbal thang... AndrewXOn |
All times are ET (US) | |
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posted October 13, 2000 12:18 PM