Supreme there is definitely something wrong with the Anavar I was taking. It works big time in relation to increased strength and glycogen storage. But both times I have been on it within 2 days I get something that feels like an intestinal reaction and a dull ache in my right testicle.

I have since seen two doctors my general practioner and a high ranking urologist in So Cal. Both said they could find nothing wrong with me. Prostate was normal size, no urine infection signs. Sperm/seminal fluid was normal with no white blood cell count elevation. Also I don't have an inquinal hernia. I have no noticeable growths on my testes or epididymis so testicular cancer was ruled out as well. No loss of urine flow, but have had bouts of "dribbling" and a sudden urge to urinate during the day. Strange is all I can say. The uro said that sometimes lifting heavy weights with a full bladder can compress urine into the vas deferens and cause a bacterial infection that could cost the "movement" I felt with the localization of the ache. ??? WTF.

My urologist said to come back if the pain didn't subside within two weeks. The pain is gone but the "dribbling" has remained a bit. Not as noticeable though.

I was only using 4-5 tabs of Anavar a day and in the AM only to try an not disturb HPTA.(I was off all during this time so I was not inhibited)

All I can say is the shit worked big time. I guess my prostate wasn't swelling although I had all the signs that it was. It does and will cause hair loss though. At least this brand does.(on me thinning with a few hairs falling out daily..I have a thick head of hair, but running my hands through my hair in the morning and scraping off strands is not my idea of fun....

And I am not prone to the MPB gene. I hope to God their isn't some sort of impurity/s in the stuff that was causing my reaction/problem.

I think I'm gonna post this as a new topic so that others can read about it and be forewarned. I have nothing against Tokkyo labs and get the gear from a trusted source in TJ.(Alot of you know who I'm referring to) I hope for everyone's sake the stuff is ok and it is just some sort of personal reaction.

Peace,

Take care!

quote:

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I was only using 4-5 tabs of Anavar a day and in the AM only to try an not disturb HPTA.(I was off all during this time so I was not inhibited)

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Anavar does not impair HPTA function AT ANY DOSAGE. This is odd however, I wouldn't say something is wrong with the anavar though, I know 2 people personally that are now/or just got done with a cycle and both are considerably higher doses than 10mg-12.5mg you are on (they are at around 20-25). The one who finished had no problems at all other than being too damn strong for his own good, and the other is just past mid cycle - so it maybe a little too early to tell for him.

Well Tony I sincerely hope everything will be ok for you, and you find the root of all the problems. The hair thing i have no idea about, ill ask the guys if they have noticed anything.

good luck!

Tony, did you tell your doctor that you were on the oxandrolone?

I've seen the test results on the Ttokkyo products, and from what I can tell as a chemist, they look good and quite clean. I still would like to try it for myself.

How long have you been off the other drugs? That is something that could have an impact.

It seems so strange. Shit, you should not have had those symptons.

In males:
Prepubertal: Phallic enlargement and increased frequency or persistence of erections.
Postpubertal: Inhibition of testicular function, testicular atrophy and oligospermia, impotence, chronic priapism, epididymitis, and bladder irritability.

Slopain I have to tell you, Anavar absolutely can effect HPTA. Anyone who tells you anything else is deluding themselves. If you have read this in any scientific journal or publication it is completely wrong.

Anavar is an androgen and even though it is mild, if used in high enough dosages it will cause inhibition. I have that on good authority from more than likely the most knowledgeable person in this business. He has experimented with dosages of up 200mgs per day of Anavar.

Gymrat, thanks for telling me that. I did read that information on the Oxandrin website beforehand but like you said was worried about the "testicular ache". The problem now is I don't know if the "ache" was actually what it seemed. Based on what the Uro said, it may have been irritability of the bladder that caused the "pain". Who the fuck knows?

I don't know the guy(first time I saw him, uncomfortable telling him I use AAS)so I didn't tell the dude I was using Oxandrolone.

I have since stopped using it.(9 days now)and the "ache" is gone. The only residual side effects I'm still experiencing is a bit of "dribbling" or not completely emptying of my bladder upon urination. No loss of flow, just a bit of drippage after. Again my Uro said my prostate is fine, no infection, no BPH, no growth around epididymis/testicle.

He did say if the pain didn't go away, he'd do an ultrasound and an abdominal cavity CT to check for anything that shouldn't be there.(Pain is gone so hmmmm)

I wonder if Anavar can cause any kind of intestinal infection? Does bladder irritability indicate an infection or perhaps lead to it?

Any uro's reading this board? Anyone have a uro they could ask those questions to?

Gymrat, would you email me backchannel. I have some questions for you.

Thanks again to everyone.

And I don't know who that guy is, but my medical journal does say it can cause testicular inhibition. This is confusing to say the least.

I don't believe in my heart of hearts that there is any drug that is completely inhibitory proof. I will ask my guru about this doctor's information.

Would you mind asking him about my problem and see if he can offer any advice? Is the dude a Urologist?

Thanks for the info. Sorry to continue to add to the confusion.

Mosby's GenRx�, 10th ed.
Copyright � 2000 Mosby, Inc.
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Oxandrolone (001925)

CATEGORIES:

Indications: Pain, secondary to osteoporosis; Weight loss
Pregnancy Category X
Orphan Drugs; DEA Class CIII

BRAND NAMES: Lonavar (Australia, Japan); Oxandrin (US); Vasorome (Japan);
(International brand names outside U.S. in italics)

COST OF THERAPY: $ 2737.50 (Osteoporosis; Oxandrin Tablet; 2.5 mg; 2/day; 365 days)

DESCRIPTION:

Oxandrin oral tablets contain 2.5 mg of the anabolic steroid oxandrolone. Oxandrolone is 17beta-hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one.

Inactive ingredients include corn starch, lactose, magnesium stearate, and hydroxypropyl methylcellulose.

CLINICAL PHARMACOLOGY:

Anabolic steroids are synthetic derivatives of testosterone. Certain clinical effects & adverse reactions demonstrate the androgenic properties of this class of drugs. Complete dissociation of anabolic and androgenic effects has not been achieved.

The actions of anabolic steroids are therefore similar to those of male sex hormones with the possibility of causing serious disturbances of growth and sexual development if given to young children. Anabolic steroids suppress the gonadotropic functions of the pituitary and may exert a direct effect upon the testes.

During exogenous administration of anabolic androgens, endogenous testosterone release is inhibited through inhibition of pituitary luteinizing hormone (LH). At large doses, spermatogenesis may be suppressed through feedback inhibition of pituitary follicle-stimulating hormone (FSH).

Anabolic steroids have been reported to increase low-density lipoproteins and decrease high-density lipoproteins. These levels revert to normal on discontinuation of treatment.

INDICATIONS AND USAGE:
Oxandrin is indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. (See DOSAGE AND ADMINISTRATION.)

CONTRAINDICATIONS:

1. Known or suspected carcinoma of the prostate or the male breast.

2. Carcinoma of the breast in females with hypercalcemia (androgenic anabolic steroids may stimulate osteolytic bone resorption).

3. Pregnancy, because of the possible masculinization of the fetus. Oxandrolone has been shown to cause embryotoxicity, fetotoxicity, infertility, and masculinization of female animal offspring when given in doses 9 times the human dose.

4. Nephrosis or nephrotic phase of nephritis.

5. Hypercalcemia.

WARNINGS: PELIOSIS HEPATITIS, A CONDITION IN WHICH LIVER AND SOMETIMES SPLENIC TISSUE IS REPLACED WITH BLOOD-FILLED CYSTS, HAS BEEN REPORTED IN PATIENTS RECEIVING ANDROGENIC ANABOLIC STEROID THERAPY. THESE CYSTS ARE SOMETIMES PRESENT WITH MINIMAL HEPATIC DYSFUNCTION, BUT AT OTHER TIMES THEY HAVE BEEN ASSOCIATED WITH LIVER FAILURE. THEY ARE OFTEN RECOGNIZED UNTIL LIFE-THREATENING LIVER FAILURE OR INTRA-ARTERIAL HEMORRHAGE DEVELOPS. WITHDRAWAL OF DRUG USUALLY RESULTS IN COMPLETE DISAPPEARANCE OF LESIONS.

LIVER CELL TUMORS ARE ALSO REPORTED. MOST OFTEN THESE TUMORS ARE BENIGN AND ANDROGEN-DEPENDENT, BUT FATAL MALIGNANT TUMORS HAVE BEEN REPORTED. WITHDRAWAL OF DRUG OFTEN RESULTS IN REGRESSION OR CESSATION OF PROGRESSION OF THE TUMOR. HOWEVER, HEPATIC TUMORS ASSOCIATED WITH ANDROGENS OR ANABOLIC STEROIDS ARE MUCH MORE VASCULAR THAN OTHER HEPATIC TUMORS AND MAY BE SILENT UNTIL LIFE- THREATENING INTRA-ABDOMINAL HEMORRHAGE DEVELOPS, BLOOD LIPID THAT ARE KNOWN TO BE ASSOCIATED WITH INCREASED RISK OF ATHEROSCLEROSIS ARE SEEN IN PATIENTS TREATED WITH ANDROGENS OR ANABOLIC STEROIDS. THESE CHANGES INCLUDE DECREASED HIGH-DENSITY LIPOPROTEINS AND SOMETIMES INCREASED LOW-DENSITY LIPOPROTEINS. THE CHANGES MAY BE VERY MARKED AND COULD HAVE A SERIOUS IMPACT ON THE RISK OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE.

Cholestatic hepatitis and jaundice may occur with 17-alpha-alkylated androgens at a relatively low dose. If cholestatic hepatitis with jaundice appears or if liver function tests become abnormal, oxandrolone should be discontinued and the etiology should be determined. Drug-induced jaundice is reversible when the medication is discontinued.

In patients with breast cancer, anabolic steroid therapy may cause hypercalcemia by stimulating osteolysis. Oxandrolone therapy should be discontinued if hypercalcemia occurs.

Edema with or without congestive heart failure may be a serious complication in patients with preexisting cardiac, renal, or hepatic disease. Concomitant administration of adrenal cortical steroids or ACTH may increase the edema.

In children, androgen therapy may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect results in compromised adult height. The younger the child, the greater the risk of compromising final mature height. The effect on maturation should be monitored by assessing bone age of the left wrist and hand every six months. (See PRECAUTIONS, Laboratory Tests.)

Geriatric patients treated with androgenic anabolic steroids may be at an increased risk for the development of prostatic hypertrophy and prostatic carcinoma.

ANABOLIC STEROIDS HAVE NOT BEEN SHOWN TO ENHANCE ATHLETIC ABILITY.

PRECAUTIONS:

General
Women should be observed for signs of virilization (deepening of the voice, hirsutism, acne, clitoromegaly). Discontinuation of drug therapy at the time of evidence of mild virilism is necessary to prevent irreversible virilization. Some virilizing changes in women are irreversible even after prompt discontinuance of therapy and are not prevented by concomitant use of estrogens. Menstrual irregularities may also occur.

Anabolic steroids may cause suppression of clotting factors II, V, VII, and X, and an increase in prothrombin time.

Information for the Patient
The physician should instruct patients to report any of the following side effects of androgens:

Males: Too frequent or persistent erections of the penis, appearance or aggravation of acne.

Females: Hoarseness, acne, changes in menstrual periods, or more facial hair.

All patients: Nausea, vomiting, changes in skin color, or ankle swelling.

Laboratory Tests

Women with disseminated breast carcinoma should have frequent determination of urine and serum calcium levels during the course of therapy (see WARNINGS).

Because of the hepatotoxicity associated with the use of 17-alpha-alkylated androgens, liver function tests should be obtained periodically.

Periodic (every 6 months) x-ray examinations of bone age should be made during treatment of children to determine the rate of bone maturation and the effects of androgen therapy on the epiphyseal centers.

Serum lipids and high-density lipoprotein cholesterol determinations should be done periodically as androgenic anabolic steroids have been reported to increase low-density lipoproteins and decrease high-density lipoproteins. Serum cholesterol levels may increase during therapy. Therefore, caution is required when administering these agents to patients with a history of myocardial infarction or coronary artery disease. Serial determinations of serum cholesterol should be made and therapy adjusted accordingly.

Hemoglobin and hematocrit should be checked periodically for polycythemia in patients who are receiving high doses of anabolic steroids.

Drug/Laboratory Test Interactions

Anabolic steroids may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged. In addition, a decrease in PBI and radioactive iodine uptake may occur.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Animal Data: Oxandrolone has not been tested in laboratory animals for carcinogenic or mutagenic effects. In two-year chronic oral rat studies, a dose related reduction of spermatogenesis and decreased organ weights (tests, prostate, seminal vesicles, ovaries, uterus, adrenals, and pituitary) were shown.

Human Data: Liver cell tumors have been reported in patients receiving long-term therapy with androgenic anabolic steroids in high doses (see WARNINGS). Withdrawal of the drugs did not lead to regression of the tumors in all cases.

Geriatric patients treated with androgenic anabolic steroids may be at an increased risk for the development of prostatic hypertrophy and prostatic carcinoma.

Pregnancy, Teratogenic Effects, Pregnancy Category X
See CONTRAINDICATIONS.

Nursing Mothers

It is not known whether anabolic steroids are excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from oxandrolone, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Anabolic agents may accelerate epiphyseal maturation more rapidly than linear growth in children and the effect may continue for six months after the drug has been stopped. Therefore, therapy should be monitored by x-ray studies at six-months intervals in order to avoid the risk of compromising adult height. Androgenic anabolic steroid therapy should be used very cautiously in children and only by specialists who are aware of the effect on bone maturation. (See WARNINGS.)

DRUG INTERACTIONS:

Anticoagulants: Anabolic steroids may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may have to be decreased in order to maintain desired prothrombin time. Patients receiving oral anticoagulant therapy require close monitoring, especially when anabolic steroids are started or stopped.

Oral hypoglycemic agents: Oxandrolone may inhibit the metabolism of oral hypoglycemic agents.

Adrenal steroids or ACTH: In patients with edema, concomitant administration with adrenal cortical steroids or ACT may increase the edema.

ADVERSE REACTIONS:

The following adverse reactions have been associated with use of anabolic steroids:

Hepatic: Cholestatic jaundice with, rarely, hepatic necrosis and death. Hepatocellular neoplasms and peliosis hepatitis with long term therapy (see WARNINGS). Reversible changes in liver function tests also occur including increased bromsulfophthalein (BSP) retention, and increases in serum bilirubin, aspartate aminotransferase (AST, SGOT), and alkaline phosphatase.

In Males: Prepubertal: Phallic enlargement and increased frequency or persistence of erections. Postpubertal: Inhibition of testicular function, testicular atrophy and oligospermia, impotence, chronic priapism, epididymitis, and bladder irritability.

In Females: Clitoral enlargement, menstrual irregularities.

CNS: Excitation, insomnia, depression, and changes in libido.

Gastrointestinal: Nausea, vomiting, diarrhea.

Hematologic: Bleeding in patients on concomitant anticoagulant therapy.

Breast: Gynecomastia.

Larynx: Deepening of the voice in females.

Hair: Hirsutism and male pattern baldness in females.

Skin: Acne (especially in females and prepubertal males).

Skeletal: Premature closure of epiphyses in children (see PRECAUTIONS, Pediatric Use).

Fluid and electrolytes: edema, retention of serum electrolytes (sodium chloride, potassium, phosphate, calcium).

Metabolic/Endocrine: Decreased glucose tolerance (see PRECAUTIONS), increased serum levels of low-density lipoproteins and decreased level of high-density lipoproteins (see PRECAUTIONS, Laboratory Tests), increased creatinine excretion, increased serum levels of creatinine phosphokinase (CPK). Masculinization of the fetus. Inhibition of gonadotropin secretion.

DRUG ABUSE AND DEPENDENCE:

Oxandrolone is classified as a controlled substance under the Anabolic Steroids Control Act of 1990 and has been assigned to Schedule III (non-narcotic).

OVERDOSAGE:

No symptoms or signs associated with overdosage have been reported. It is possible that sodium and water retention may occur..

The oral LD50 of oxandrolone in mice and dogs is greater then 5000 mg/kg. No specific antidote is known, but gastric lavage may be used.

DOSAGE AND ADMINISTRATION:
Therapy with anabolic steroids is adjunctive to and not a replacement for conventional therapy. The duration of therapy with oxandrolone will depend on the response of the patient and the possible appearance of adverse reactions. Therapy should be intermittent.

Adults: The usual adult dosage of Oxandrin is one 2.5 mg tablet two to four times daily. However, the response of individuals to anabolic steroids varies, and a daily dosage of as little as 2.5 mg or as much as 20 mg may be required to achieve the desired response. A course of therapy of two to four weeks is usually adequate. This may be repeated from intermittently as indicated.

Children: For children the total daily dosage of oxandrolone is 0.1 mg per kilogram body weight or 0.045 mg per pound of body weight. This may be repeated intermittently as indicated.
--------------------------------------------------------------------------------

HOW SUPPLIED:

quote:

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"For what it's worth..."

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Later,

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Would you mind me asking you some questions backchannel? And by no means am I a physician.

I would appreciate your input.

Thanks.