posted August 16, 2000 11:42 AM         

[The behavior of hGH (human growth hormone) and somatomedin C following anesthesia induction with propofol in comparison with diazepam and thiopental].

[Article in German]

Luger TJ, Fassler R, Gottardis M, Koller W, Mutz N

Klinik fur Anaesthesie und Allgemeine Intensivmedizin, Universitat Innsbruck.

It was the aim of present study to examine possible interactions between human growth hormone (hGH) and Somatomedin C (SmC), when inducting anaesthesia with propofol in healthy patients. Moreover these effects of propofol should be compared with that of diazepam and thiopentone. 30 patients scheduled for elective plastic-surgery were divided randomly into 3 groups. Induction of anaesthesia was performed in group 1 with diazepam, in group 2 with thiopentone and in group 3 with propofol. Measurements of hGH, SmC as well as blood glucose were performed at 4 different given times: (1.) preoperatively, (2.) 15 minutes, (3.) 30 minutes, (4.) 60 minutes after inducting anaesthesia. Diazepam and thiopentone lead to increases in hGH secretion already in a very early phase after induction of anesthesia (15 minutes) and remained on elevated level. Concentrations of Somatomedin C, as well as of blood glucose, however, remained unchanged during the whole observation period. In comparison to that findings propofol did not show any influence on hGH and consecutively on Somatomedin C activity at any time. Based on our results we can conclude that propofol should be the induction-agent of choice predominantly when anaesthetizing patients with unknown hormonal state (outpatients scheduled for operation).

Publication Types:
Clinical trial
Randomized controlled trial

posted August 16, 2000 11:45 AM         

J Endocrinol Invest 1985 Apr;8(2):167-70 Related Articles, Books, LinkOut

Lack of effect of im diazepam administration on hGH and hPRL secretion in normal and acromegalic subjects.

Zaccaria M, Giordano G, Ragazzi E, Sicolo N, Foresta C, Scandellari C

The usefulness of diazepam as a provocative stimulus for hGH secretion has been suggested as a simple, reliable test in clinical hGH assessment of pituitary disorders. We have investigated the effects of diazepam (10 mg im) on plasma hGH and hPRL in 5 normal and 7 acromegalic subjects. No significant variations in hGH and hPRL levels have been observed in any of the studied subjects. These findings indicate that the drug is ineffective on hGH and hPRL release and that it cannot be considered a valid provocative test either in normal or acromegalic subjects.