posted July 25, 2000 01:26 AM            

Since so much has been written about the pain, and complications involved in pgf2a use
I wanted to clarify for some just why this shit hurts so bad..makes you shit yourself to death...etc..etc...etc..

Well one of the first things you will notice about pgf2a upon injection is a sort of congestion in the lungs..similar to a small asthma attack. This is due to the fact that prostaglandins cause vasoconstriction and vasodilation in the blood vessels of the lungs. Prostaglandins also cause constrictions and dilation of the bronchial smooth muscle.

Next you may notice the particular muscle balling up, or feeling "pumped". This is somewhat due to the muscle being inflamed.
Prostaglandins can produce many inflammatory responses from the body, as well as the sensations of pain. So in essence the muscle is becoming constricted and inflamed all at once. A rise in bodytemp will result as well, because of the interaction between prostaglandins and the hypothalumus. Studies done on prostaglandins injected directly into the hypothalumus produce instant fever, there by somewhat explaining some of the fat burning potential of this drug.

As far as almost shitting yourself to death, this is what Ive come to on how it affects your GI tract. Prostaglandins are produced by the stomach and intestines. They are believed to inhibit gastric secretions, and influence gastric motility, as well as fluid absorbtion.

This may explain some of the stomach cramps that Ive gotten as well as some other bro's Ive spoken with.

Vascularity has been reported by almost everyone Ive talked to. This is because prostaglandins are vasoconstrictors as well as vasodilators. From what I understand it depends on the concentration of what prostaglandin is present.

There are also some things I had no clue about that Ive come across.

Prostaglandins are produced in the medulla of the kidneys. They increase renal blood flow and excretion of water and electrolytes in the urine. High potassium intake as been shown to increase the pfg2a secretions in animals.

Prostaglandins are known to be regulators of protein in skeletal muscle. Pge2 and pgf2a are both involved in the rates of protein breakdown and synthesis. Stretch induced hypertrophy of skeletal muscle is in part regulated by prostaglandins.

So this is all good..but why the hell does it cause muscle growth WCP you shithead..just tell us the good stuff...right??

This is what Ive dug up on this aspect.
Mechanical stimulation (i.e. intermittent stretch) results in the production and efflux of 2 prostaglandings, pge2 and pgf2a.
Pge2 increased protein degradation while pgf2a increases protein sythesis. Muscle hypertrophy is usually achieved by an increase in protein synthesis and a proportionately increase in degradation. So the production of both creates this process.

Prostaglandins also interact with G proteins inbedded in cell membrane. G proteins increase the amount of cyclo-oxygenase, the enzyme responsible for making prostaglandins.
Skeletal muscle cyclooxygenase generates pge2 and pgf2a at a ratio exactly equal to one.

Ok Im sick of typing now...this may answer alot of questions bros may have as to the hows and whys behind what seems to be destined the "next big thing" in bodybuilding. I will post more about how PG's affect protein, when I find more on it.

Enjoy,
WCP

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"Man doth not yeild himself unto the Angels, nor unto Death utterly......save only through the weakness of his feeble will"
--Joseph Glanvill

posted July 25, 2000 01:35 AM            

truely a mystery drug to me, and most people i think... thanks for clearing some of it up.

Thanks bro!

posted July 25, 2000 01:37 AM            

ranger told you to check your bodyfat levels...any noticable change? what of the localized growth your experiencing...is it translating into a qualitative growth?

nice to see you sticking it out

posted July 25, 2000 05:09 AM            

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Jeff

Don't look back, life is too short

posted July 25, 2000 11:59 AM            

I burn a lot of fat on it.
I'm gaining a lot of size and vascularity on my arms.
I get the liquid shits bigtime, and it feels funny when I breathe after I take an injection.
It feels like you're injecting battery acid into the muscle, it hurts that bad.
The pumps I get while on are insane.... feels like the muscle is gonna explode.
I love it.
If you don't like pain... don't do PGF2a.
There is no formula or cycle advice that works for everyone. You HAVE TO EXPERIMENT with it, to see what works for you.

posted July 25, 2000 04:38 PM         

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legend