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Author | Topic: -> LIPO K . <- |
Frackal Pro Bodybuilder (Total posts: 371) |
![]() ![]() ![]() ![]() Thinking of trying out Lipokinetix for my cutting cycle in August. Information on this product is pretty limited, and I'm hoping I can get some first hand experiences and maybe some links or posts with info on it's dangers, mass preservation properties, etc.. Mods comments would be much appreciated. IP: Logged |
BigTruck Amateur Bodybuilder (Total posts: 54) |
![]() ![]() ![]() ![]() This is an excerpt from an article I read awhile back that spoke about a different supplement that contained usnic acid (the active ingredient in Lipokintex). Usnic acid is a naturally occurring chemical typically found in the Unsnea laevis Nylander (a lichen) native to the Venezuelan Andes mountains1 where the lichen is used by primitive endogenous farmers as an antibiotic. And, not surprisingly, the drug and medical community has been studying the substance for 20 years or so for possible use in a variety of applications. Most recently, usnic acid, when applied topically, has been found to be quite useful in treating intravaginal genital warts (human papillomavirus lesions),2 being almost 100% effective at destroying the warts when used in conjunction with zinc sulfate. While this is utterly fascinating to the readership, and probably even more so to our promiscuous readers, usnic acid has some other characteristics and uses that I'm sure you'll find a bit more worrisome and more appropriate for a "Consumer Watchdawg" article. Usnic acid has rather profound antimycobacterial effects against tuberculosis-type organisms3 and its antimitotic (read "stops cell division in its tracks") effects on a cornucopia of biological systems�including humans4�are dangerously intriguing. And yes, much to Duchaine's credit, usnic acid exhibits the characteristics of 2,4-dinitrophenonel (oxidative phosphorylation), at least in vitro against mouse liver mitochondria,5 as it probably penetrates the inner mitochondrial membrane through its lipophilic characteristics. And since we're speaking of mice and not men (although we can extrapolate the data to men, as mice and men are both mammalian systems), usnic acid has been shown to increase clastogenic (chromosome or gene breaking) action in mouse femur (bone) cells,6 something that I know we all want to avoid unless we're looking forward to osteoporosis, bone cancers, and hip replacement surgery in the near future. It was also shown in the same study to be a mitodepressive agent, possibly interfering with RNA biosynthesis and causing a marked decrease in "baby erythrocytes" (pre-red blood cells). It's believed that this effect of usnic acid is on the "spindle apparatus" (cell architecture, so to speak) which would put it in a similar category to the noted anticancer drug, Taxol! Now, Duchaine isn't the first person to "discover" interesting uses for usnic acid. Vaginal genital warts notwithstanding, the Germans used usnic acid in their deodorants. They stopped, however, when it started causing contact eczema in quite a few people,7 as well as contact dermatitis in others.8 Due to the long half-life and excellent bioavailability of oral usnic acid, it's almost inevitable that no matter what's printed on the warning label on the bottle, someone will overdose and really hurt themselves with this chemical. Also, usnic acid, once inside your bloodstream, is highly protein-bound at a level of approximately 99.2%. Tissue distribution studies of usnic acid undertaken in rats showed that usnic acid was well distributed into well-perfused organs.10 The tissue:plasma ratio in lungs was exceptionally high, which might be advantageous if you have drug-resistant tuberculosis, but this particular property wouldn't help anybody trying to lose fat. In fact, it's readily evident that usnic acid, because it collects in well-perfused organs (heart, liver, kidney, brain, etc.), will most likely manifest symptoms of overdose in these organs. Swell, huh? So let me offer a less than genuine congratulations to Dan Duchaine for managing to bring to market what is, in my opinion, easily the nastiest, most dangerous food supplement in history. An advertisement for HPDx discloses that the "development team was led by an MD, PhD," yet this person isn't named. I find it highly dubious that this alleged person's name isn't mentioned, and I'm curious to know if the individual alluded to (if he exists at all) is licensed to practice medicine in the United States. Maybe this individual has been debarred and had his license irrevocably yanked. Or maybe he's just smart by staying out of the picture. The advertisement also touts the safety of this product in humans, yet an exhaustive literature search by yours truly failed to turn up any published data on the safety of using usnic acid in humans for fat loss. Dan, as Cuba Gooding, Jr. told Tom Cruise in the movie "Jerry Maguire," show me the money!!! Show me the human trial conducted in accordance with ICH and Declaration of Helsinki guidlelines. Dan, show me where your new "deadly fat-burner" has been clinically demonstrated to be safe and/or effective. Just show me one legit study, Dan!!! The website (www.ppproducts.com) for the company promoting this crap has, in their advertising literature, most assuredly violated FDA and FTC guidelines. The company claims to be conducting two studies at the university level with usnic acid. But for what purpose�as a last-ditch attempt to save someone who has metastic bone cancer and is likely to die anyway? When you conduct a study at any university in the United States, Canada, or Europe, you must have it approved by either an Institutional Review Board (IRB) or an Institutional Ethics Committee (IEC). There's no way around this! So here's an open challenge to Dan Duchaine: please name the universities that you claim are investigating usnic acid in the manner described at the above website. I dare you. Screw that, I double-dawg dare you!!! And another thing, shouldn't you have conducted such studies (if you're even doing so, which I'm going to come out right here and say is most likely a bold-faced lie on your part) before you sold this crap? What if the study participants grow a third nut or something? "Oops, sorry!!!" won't cut it this time. It turns out that there's someone else involved with this who has utterly left me in a replete state of disappointment and sadness. Shelly Hominuik is the owner of QFAC (Quest for Anabolic Condition), and she was the first person to actively market Duchaine's new death diet pill. In the last few days, I�along with several other people�have done everything we could to convince Ms. Hominuk that usnic acid is the most vile supplement ever created. At first, she pleaded ignorance: "...I didn't know how bad this stuff might be" is what Shelly personally conveyed to me. If you sell something, I feel that you have a moral and ethical obligation to know something about what you're selling beforehand, especially if the information is readily available. But I gave Hominuk the benefit of the doubt and sent her 47 published abstracts from peer-reviewed journals describing how vile usnic acid is. It didn't convince her. I then appealed to her to at least remove the item from sale at her website until such a time that she could ascertain that it was either safe (and she could then resume selling it) or unsafe. Shelley Hominuk was unwilling to do this. Shelley, I would suggest that you really sit back and reflect on your priorities for a while. This truly comes as such a disappointment to me, as I've previously had all positive experiences with Shelley and QFAC. I'm quite confident that Mr. Duchaine and Ms. Hominuk will author a cogent rebuttal to my assertions. In fact, I look forward to it. Nonetheless, there's really no evidence that usnic acid is safe for casual use in humans and quite a bit of evidence that it's possibly incredibly dangerous. If I wanted to lose fat at an accelerated rate, I think that I might opt to stick with stuff like MD6, Adipokinetix (without the theophylline in it), or one of the myriad of ECA-stack clones on the market. Yeah, you can overdose on these ECA-type thermogens, for sure. But we pretty much know the side effects from ECA-type stuff and can usually treat a case of tachycardia with a beta-blocker like atenolol or propanolol. As for a mitotic spindle inhibitor (like usnic acid), the only people I know who are qualified enough to play with such drugs in humans are medical oncologists. Since I don't have cancer and don't want it, I will, as a prophylactic measure, avoid HPDx and usnic acid. My prediction is that this chemical will be yanked off the market in Y2K but will probably cause the FDA and the FTC to come down very hard on the entire industry. If this prediction comes true, you can thank Dan Duchaine and Shelley Hominuk for this personally. I'm truly sorry to bring all of you such bitter and bad tidings the night before Christmas. Please be safe and enjoy your holiday season. See you all in Y2K.
Based on this, I don't think I'd mess with it. IP: Logged |
Frackal Pro Bodybuilder (Total posts: 371) |
![]() ![]() ![]() ![]() Thanks. I've read that one (it's from T-mag) but I don't know how biased they're going to be about this product. Article does do a good job of scaring you though. IP: Logged |
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