posted June 19, 2000 12:57 AM            

HAIR LOSS:

Deca is easier on the hair than others, including natural testosterone, because it is converted in the scalp to a steroid weaker than Deca is. (DHN i believe)Nandrolone itself is a 5a -reductase inhibitor (although it yields DHN in the process). So less DHT is produced if nandrolone is present. Nandrolone will also inhibit natural production of testosterone, so there is less testosterone available to be converted to DHT.

Testosterone is harder on the hair and skin than others because in the skin it is converted to a more potent steroid, DHT.

With testosterone it is desirable to inhibit the 5AR enzymes so that less is converted to DHT. Azelaic acid seems to be the best thing to apply to the skin for this. Azelaic acid cream is available by prescription for treating acne, and, for the scalp, a preparation that also includes minoxidil is available from http://www.minoxidil.com.

With any androgen, blocking the androgen receptors in the scalp or facial skin will help avoid male pattern baldness or acne, respectively. Spironolactone has the disadvantage of yielding a bit of a wet-dog odor on metabolism or decomposition as it yields thioacetic acid, but it seems to be the best thing currently available.

The only commercially available AAS for human use which converts to DHT is testosterone. All others have modifications to the structure which make it absolutely impossible for them to be converted to DHT per se (dihydrotestosterone).

The testosterone user has high levels of DHT in the scalp, and therefore a lot of androgen in the scalp. The nandrolone user has low levels of DHT, instead having DHN, which is less potent.

Furthermore, DHT probably has hair loss activities not mediated by the androgen receptor, but by other proteins in the scalp and via the immune system. DHN may not have these activities.

More importantly, what is observed is that nandrolone is quite good for keeping one's hair, whereas testosterone is not, for those genetically predestined to lose their hair.

The price one pays for this, though, is that nandrolone is not as effective an anabolic as testosterone.

Primobolan and Winstrol act differently from DHT in that, unlike DHT, they are not converted to androstanediol. They are comparable in effect on the hair to anabolically-equivalent doses of any other synthetic except nandrolone.

If you stick to the 19-nortestosterone compounds (like Deca, Parabolin, Durabolin, Laurabolin, ect.....) you will avoid the DHT-induced hair loss that is seen with compounds that convert to DHT (eg. the testosterones). The Nandrolones (nortestosterone derivatives) are chemically unable to convert to DHT.

a person, who simply wishes to have an attractive physique and appearance by conventional standards, and highly values the condition of his skin and hair, would be poorly served by the advice to use Sustanon or Dianabol at any dose. The likely worsening of his skin and possible acceleration of hair loss would not be worth it. He would be better served with a milder drug, which would allow him to achieve his goals with minimal cosmetic or health risk. Some have found that Proscar acts to minimize effects of testosterone use on skin and hair. The objection that reduced conversion to DHT might reduce muscular growth may have some validity. This might be true either because of loss of DHT activity on nervous tissue, or because of possible loss of non-AR-mediated effects of androstanediol, a DHT metabolite, or an indirect effect not occurring in muscle tissue itself. DHT itself is not an effective anabolic for muscle tissue. If one chooses to use Proscar to minimize risk of hair loss, I would suggest topical use to the scalp, or if used orally, certainly not in excess of the recommended dose for medically-indicated use.

If you are on testosterone, anti-DHT Proscar � can reduce the side effects of this hormone a little. As DHT contributes to testicular atrophy, Proscar while on steroids can be of some use. Do not expect too much though. You can start with one pill (5 mg) a day for 3 to 5 days, then you can take one every third day.

winstrol is not a precursor of DHT, but is itself a potent agonist of the AR in skin and scalp.

Deca. Or with other steroids (actually, even with Deca for that matter) you could use topical spironolactone (available from http://www.minoxidil.com/). Among its other properties as an anti-androgen, spironolactone is a potent competitive inhibitor of DHT at its receptor sites[21]. Therefore, spironolactone effectively prevents DHT from attaching to the receptor sites on the hair follicles[22]. As a result, the follicles no longer atrophy and can mature again to their normal size. And it does so without decreasing the circulating levels of DHT in the body. By comparison, finasteride inhibits the formation of DHT, causing troublesome side effects in many patients.

perhaps the most effective hair growth drug currently available is called XANDROX 12.5%. It is a lotion that contains 12.5% micronized minoxidil and 5% azelaic acid. Its base is water-soluble and absorbs into the skin. It also contains an effective transdermal absorption enhancer. Because the concentration of minoxidil is so high in this new lotion, it is suggested that no more than one mL of it be applied daily. It is formulated to be used as a supplement to the Xandrox 5% solutions, which were made available seven months ago from Regrowth. XANDROX 12.5% is designed to fill the void and treat those stubborn areas of the scalp, which may not be responding adequately to other therapies. These areas often include the temples, frontal hairline or, in some cases, the vertex and crown. Because minoxidil is dose dependent, XANDROX 12.5% is specifically beneficial in these areas. The results of combining the hair growth properties of minoxidil with the ability of azelaic acid to inhibit virtually all dihydrotestosterone (DHT) in the scalp have proven to be extremely effective in halting and reversing MPB for the vast majority of patients. Nighttime and daytime Xandrox 5% solutions are available with and without 0.025% retinoic acid, respectively. Xandrox 12.5% lotion incorporates an absorption enhancer and does not contain Retin-A or betamethasone valerate. 30-mL bottles cost $27.86 and are fitted with a pump dispenser.

peace,