posted May 30, 2000 11:15 PM            

---

I came across this stuff called Glucophage. Some say that it is kind of like Insulin, but less dangerous. Some say it is better than insulin because it stimulates more IGF1 production from the liver.
~~~~~~~~~~~~~

IP: Logged

posted May 30, 2000 11:26 PM            

---

It's a glucose disposal agent, I think. Lyle MacDonald says its real good for the ketogenic diet. Are you in America and is it legal like Clomid?

IP: Logged

posted May 30, 2000 11:36 PM            

---

I was considering getting some for a keto diet since i can't get humalin how would you use it in conjuction with geore spellwins or any other keto diet.

IP: Logged

posted May 30, 2000 11:44 PM            

---

Metformin (glucophage) CAN be very dangerous if used improperly. It works nothing like insulin but used for type II diabetes.

Unless you are educated...dont use it.

IP: Logged

posted May 31, 2000 12:07 AM            

---

go to www.glucophage.com, a really cool site. Here's some more:

Metformin is a biguanide that has been used worldwide for the treatment of type 2 diabetes for the past 4 decades. It improves glycemic control by enhancing insulin sensitivity in liver and muscle. Metformin does not stimulate insulin secretion and therefore is not associated with hypoglycemia. Improved metabolic control with metformin does not induce weight gain and may cause weight loss. Metformin also has a beneficial effect on several cardiovascular risk factors including dyslipidemia, elevated plasminogen activator inhibitor 1 levels, other fibrinolytic abnormalities, hyperinsulinemia, and insulin resistance. While metformin reduces insulin resistance, the cellular mechanism of action is incompletely understood. Metformin enhances muscle and adipocyte insulin receptor number and/or affinity, increases insulin receptor tyrosine kinase activity, stimulates glucose transport and glycogen synthesis, and reduces both hepatic gluconeogenesis and glycogenolysis. In addition, metformin has been reported to decrease lipid oxidation and plasma free fatty acid levels, leading to an inhibition of an overactive Randle cycle. Metformin monotherapy decreases the fasting plasma glucose concentration by ~60�70 mg/dl and HbA1c by 1.5�2.0% in patients with type 2 diabetes. The biguanide is completely additive to sulfonylureas and vice versa, as well as to acarbose and probably troglitazone. In insulin-treated type 2 diabetic patients, the addition of metformin improves insulin sensitivity and glycemic control while allowing a reduction in the daily insulin dose. Side effects of metformin are primarily confined to the gastrointestinal tract (abdominal discomfort and diarrhea). These side effects can be minimized by slow titration and administration with food. Lactic acidosis is rare, with an incidence of ~3 cases per 100,000 patient-years of therapy. Most reported cases of lactic acidosis occur in patients with contraindications, particularly impaired renal function (>90% of cases). In summary, metformin is an effective and safe therapeutic agent for the treatment of type 2 diabetes. Its ability to improve insulin sensitivity and the cardiovascular risk profile of type 2 diabetic patients has enhanced its clinical use as first-line therapy. In the U.K. Prospective Diabetes Study, metformin was the only medication that reduced diabetes-related death, heart attacks, and stroke. Metformin recently has been approved for use in poorly controlled, insulin-treated type 2 diabetic subjects. In the future, its indications may expand to insulin-resistant patients at a high risk of developing type 2 diabetes or with other components of the insulin resistance syndrome.

IP: Logged

posted May 31, 2000 12:16 AM            

---

*yawn*
that last copy and paste job does 99% of us no good whatsoever.

IP: Logged

posted May 31, 2000 12:16 AM            

---

I ordered some and was wondering also how do I get it to work on george spellwin's ketogenic diet or bodyopus.

IP: Logged

posted May 31, 2000 12:20 AM            

---

Hey Ripp reread the "cut and paste job". This is exactly what WE need. I guess either you didn't fucking read it or you don't fucking understand it. Take your shit elsewhere unless you've got something to add.

IP: Logged

posted May 31, 2000 12:54 AM            

---

ok beastmaster I re-read it. But I did yawn again...sorry. Let me just ask you one thing...would you recommend it for anything other than diabetes (ie. bodybuilding)? If so why?

PS. Metforming does cause hypoglycemia and lactic acidosis is more common than stated. Other than that it was informative.

IP: Logged

posted May 31, 2000 01:18 AM            

---

"It improves glycemic control by enhancing insulin sensitivity in liver and muscle"...there's one pro for the keto diet

IP: Logged

posted May 31, 2000 02:00 AM            

---

"enhancing insulin sensitivity in the liver and muscle".......????????????????????

I dont want to sound like an asshole but....oh nevermind.

For anyone that cares...using this agent will take alot of research...be careful with this...and i mean really research it.

IP: Logged

All times are ET (US)