posted May 21, 2000 01:02 PM            

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I need some info from all you endocrinologist want-a be's. Reading this board for the last couple of years I have learned one inportant thing. Many of you guys know as much or more than my Doctor. I need some info!! I had a male hormone panel done and I'am all screwed up. My dhea was fine,my androstenedione was fine but where the convergence to testosterone should take place it was converging to estrone. My estrone levels were off the friggen chart, while my progesterone levels were vary vary low. So as you might susspect my testosterone levels were alot lower than a man of 44 should be. My question to all you knowlagable guys is this. Why is the convergence to estrone happening and what are the long term effects of clomid usage at a small dosage of like 15mg eod. Also what exactly is dht it was also low. By the looks of a pathway map everything is going to estrone but why, what can cause that?

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posted May 21, 2000 02:08 PM            

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bump

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posted May 21, 2000 03:20 PM            

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Testosterone converts to Estradiol with the help of P450aromatase ezyme.
DHT is dehydrotestosterone, Testosterone converts to DHT with 5alpha-reductase. DHT is responsible for most of the masculine features such as male pattern baldness.

By no means am I an expert but my GUESS is that you have got overactive P450aromatase.
Does anyone know of an inhibitor of this enzyme?

/Komo

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posted May 21, 2000 06:09 PM            

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bump

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posted May 21, 2000 07:12 PM            

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I am no expert either but it does sound like you have high levels of aromatase. An anti-aromatase drug, such as arimidex or cytraden could help, but your doctor should know this. Finding a new doctor could help too.

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posted May 21, 2000 07:24 PM            

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by the looks of it you are slowly turning into a female. This is a rare thing that happens but you will be ok. Start looking for bras and panties....hahaha

just kidding...Go see a specialist in this field...there are cases of acute hepatocellular carcinomas (cancer of liver) causing your skewed lab results but highly unlikely.

Aromatase (estrogen synthetase) is the enzyme complex responsible for the final step in estrogen synthesis--the conversion of
androstenedione and testosterone to estrone and estradiol, respectively. Inhibitors of this enzyme have been shown to be
clinically effective in the treatment of advanced breast cancer,in whom the major source of estrogen production derives from aromatization of adrenal androgens in peripheral tissues, such as muscle, liver, and fat. The most widely used aromatase inhibitor has been aminoglutethimide. There are many others incuding monoclonals. Getting off track here...basically go see your specialist before you start liking guys.

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